Inhibiting LXRα phosphorylation in hematopoietic cells reduces inflammation and attenuates atherosclerosis and obesity in mice

Voisin et al. show that reducing phosphorylation at serine 196 of LXRα (LXRα pS196) in hematopoietic cells attenuates atherosclerosis and obesity of mice fed a high-fat diet. They find that the transcriptional activity of LXRα is reprogrammed in macrophages and T cells to promote an anti-inflammator...

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Autores principales:	Maud Voisin, Elina Shrestha, Claire Rollet, Cyrus A. Nikain, Tatjana Josefs, Mélanie Mahé, Tessa J. Barrett, Hye Rim Chang, Rachel Ruoff, Jeffrey A. Schneider, Michela L. Garabedian, Chris Zoumadakis, Chi Yun, Bara Badwan, Emily J. Brown, Adam C. Mar, Robert J. Schneider, Ira J. Goldberg, Inés Pineda-Torra, Edward A. Fisher, Michael J. Garabedian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c5802b4ff1e54135a67ab96e212ab5fd
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spelling	oai:doaj.org-article:c5802b4ff1e54135a67ab96e212ab5fd2021-12-02T16:36:02ZInhibiting LXRα phosphorylation in hematopoietic cells reduces inflammation and attenuates atherosclerosis and obesity in mice10.1038/s42003-021-01925-52399-3642https://doaj.org/article/c5802b4ff1e54135a67ab96e212ab5fd2021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01925-5https://doaj.org/toc/2399-3642Voisin et al. show that reducing phosphorylation at serine 196 of LXRα (LXRα pS196) in hematopoietic cells attenuates atherosclerosis and obesity of mice fed a high-fat diet. They find that the transcriptional activity of LXRα is reprogrammed in macrophages and T cells to promote an anti-inflammatory phenotype, thus identifying a functional role of LXRα pS196 in immune cells.Maud VoisinElina ShresthaClaire RolletCyrus A. NikainTatjana JosefsMélanie MahéTessa J. BarrettHye Rim ChangRachel RuoffJeffrey A. SchneiderMichela L. GarabedianChris ZoumadakisChi YunBara BadwanEmily J. BrownAdam C. MarRobert J. SchneiderIra J. GoldbergInés Pineda-TorraEdward A. FisherMichael J. GarabedianNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Maud Voisin Elina Shrestha Claire Rollet Cyrus A. Nikain Tatjana Josefs Mélanie Mahé Tessa J. Barrett Hye Rim Chang Rachel Ruoff Jeffrey A. Schneider Michela L. Garabedian Chris Zoumadakis Chi Yun Bara Badwan Emily J. Brown Adam C. Mar Robert J. Schneider Ira J. Goldberg Inés Pineda-Torra Edward A. Fisher Michael J. Garabedian Inhibiting LXRα phosphorylation in hematopoietic cells reduces inflammation and attenuates atherosclerosis and obesity in mice
description	Voisin et al. show that reducing phosphorylation at serine 196 of LXRα (LXRα pS196) in hematopoietic cells attenuates atherosclerosis and obesity of mice fed a high-fat diet. They find that the transcriptional activity of LXRα is reprogrammed in macrophages and T cells to promote an anti-inflammatory phenotype, thus identifying a functional role of LXRα pS196 in immune cells.
format	article
author	Maud Voisin Elina Shrestha Claire Rollet Cyrus A. Nikain Tatjana Josefs Mélanie Mahé Tessa J. Barrett Hye Rim Chang Rachel Ruoff Jeffrey A. Schneider Michela L. Garabedian Chris Zoumadakis Chi Yun Bara Badwan Emily J. Brown Adam C. Mar Robert J. Schneider Ira J. Goldberg Inés Pineda-Torra Edward A. Fisher Michael J. Garabedian
author_facet	Maud Voisin Elina Shrestha Claire Rollet Cyrus A. Nikain Tatjana Josefs Mélanie Mahé Tessa J. Barrett Hye Rim Chang Rachel Ruoff Jeffrey A. Schneider Michela L. Garabedian Chris Zoumadakis Chi Yun Bara Badwan Emily J. Brown Adam C. Mar Robert J. Schneider Ira J. Goldberg Inés Pineda-Torra Edward A. Fisher Michael J. Garabedian
author_sort	Maud Voisin
title	Inhibiting LXRα phosphorylation in hematopoietic cells reduces inflammation and attenuates atherosclerosis and obesity in mice
title_short	Inhibiting LXRα phosphorylation in hematopoietic cells reduces inflammation and attenuates atherosclerosis and obesity in mice
title_full	Inhibiting LXRα phosphorylation in hematopoietic cells reduces inflammation and attenuates atherosclerosis and obesity in mice
title_fullStr	Inhibiting LXRα phosphorylation in hematopoietic cells reduces inflammation and attenuates atherosclerosis and obesity in mice
title_full_unstemmed	Inhibiting LXRα phosphorylation in hematopoietic cells reduces inflammation and attenuates atherosclerosis and obesity in mice
title_sort	inhibiting lxrα phosphorylation in hematopoietic cells reduces inflammation and attenuates atherosclerosis and obesity in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c5802b4ff1e54135a67ab96e212ab5fd
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Inhibiting LXRα phosphorylation in hematopoietic cells reduces inflammation and attenuates atherosclerosis and obesity in mice

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