PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not naïve ESCs
Polycomb repressive complex 2 (PRC2) plays an essential role in development by modifying chromatin but what this means at a cellular level is unclear. Here, the authors show that ablation of PRC2 genes in human embryonic stem cells and in mice results in changes in pluripotency and the primed state...
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Nature Portfolio
2017
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oai:doaj.org-article:c585d389c6de449fb42759c3f714e5e92021-12-02T14:42:38ZPRC2 specifies ectoderm lineages and maintains pluripotency in primed but not naïve ESCs10.1038/s41467-017-00668-42041-1723https://doaj.org/article/c585d389c6de449fb42759c3f714e5e92017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00668-4https://doaj.org/toc/2041-1723Polycomb repressive complex 2 (PRC2) plays an essential role in development by modifying chromatin but what this means at a cellular level is unclear. Here, the authors show that ablation of PRC2 genes in human embryonic stem cells and in mice results in changes in pluripotency and the primed state of cells.Yongli ShanZechuan LiangQi XingTian ZhangBo WangShulan TianWenhao HuangYanqi ZhangJiao YaoYanling ZhuKe HuangYujian LiuXiaoshan WangQianyu ChenJian ZhangBizhi ShangShengbiao LiXi ShiBaojian LiaoCong ZhangKeyu LaiXiaofen ZhongXiaodong ShuJinyong WangHongjie YaoJiekai ChenDuanqing PeiGuangjin PanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Science Q |
| spellingShingle |
Science Q Yongli Shan Zechuan Liang Qi Xing Tian Zhang Bo Wang Shulan Tian Wenhao Huang Yanqi Zhang Jiao Yao Yanling Zhu Ke Huang Yujian Liu Xiaoshan Wang Qianyu Chen Jian Zhang Bizhi Shang Shengbiao Li Xi Shi Baojian Liao Cong Zhang Keyu Lai Xiaofen Zhong Xiaodong Shu Jinyong Wang Hongjie Yao Jiekai Chen Duanqing Pei Guangjin Pan PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not naïve ESCs |
| description |
Polycomb repressive complex 2 (PRC2) plays an essential role in development by modifying chromatin but what this means at a cellular level is unclear. Here, the authors show that ablation of PRC2 genes in human embryonic stem cells and in mice results in changes in pluripotency and the primed state of cells. |
| format |
article |
| author |
Yongli Shan Zechuan Liang Qi Xing Tian Zhang Bo Wang Shulan Tian Wenhao Huang Yanqi Zhang Jiao Yao Yanling Zhu Ke Huang Yujian Liu Xiaoshan Wang Qianyu Chen Jian Zhang Bizhi Shang Shengbiao Li Xi Shi Baojian Liao Cong Zhang Keyu Lai Xiaofen Zhong Xiaodong Shu Jinyong Wang Hongjie Yao Jiekai Chen Duanqing Pei Guangjin Pan |
| author_facet |
Yongli Shan Zechuan Liang Qi Xing Tian Zhang Bo Wang Shulan Tian Wenhao Huang Yanqi Zhang Jiao Yao Yanling Zhu Ke Huang Yujian Liu Xiaoshan Wang Qianyu Chen Jian Zhang Bizhi Shang Shengbiao Li Xi Shi Baojian Liao Cong Zhang Keyu Lai Xiaofen Zhong Xiaodong Shu Jinyong Wang Hongjie Yao Jiekai Chen Duanqing Pei Guangjin Pan |
| author_sort |
Yongli Shan |
| title |
PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not naïve ESCs |
| title_short |
PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not naïve ESCs |
| title_full |
PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not naïve ESCs |
| title_fullStr |
PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not naïve ESCs |
| title_full_unstemmed |
PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not naïve ESCs |
| title_sort |
prc2 specifies ectoderm lineages and maintains pluripotency in primed but not naïve escs |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/c585d389c6de449fb42759c3f714e5e9 |
| work_keys_str_mv |
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