FEATURES OF CYTOKINE-MEDIATED REGULATION OF FOCAL AND SYSTEMIC INFLAMMATION IN COPD

Chronic obstructive pulmonary disease (COPD) is associated with pulmonary and systemic inflammation. The latter is likely to contribute significantly to the pathobiology of numerous extrapulmonary effects of the disease, i.e., systemic effects of COPD. The main causes of systemic inflammation in COP...

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Autores principales:	E. A. Surkova, N. A. Kuzubova, T. P. Ses’, Areg A. Totolian
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	cytokines inflammation copd Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/c5862be2891146cd9dbaab071026ed4d
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spelling	oai:doaj.org-article:c5862be2891146cd9dbaab071026ed4d2021-11-18T08:03:38ZFEATURES OF CYTOKINE-MEDIATED REGULATION OF FOCAL AND SYSTEMIC INFLAMMATION IN COPD1563-06252313-741X10.15789/1563-0625-2010-4-5-349-354https://doaj.org/article/c5862be2891146cd9dbaab071026ed4d2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/181https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XChronic obstructive pulmonary disease (COPD) is associated with pulmonary and systemic inflammation. The latter is likely to contribute significantly to the pathobiology of numerous extrapulmonary effects of the disease, i.e., systemic effects of COPD. The main causes of systemic inflammation in COPD remain to be elucidated. A course of local vs. systemic inflammation is determined by an imbalance between pro- and anti-inflammatory cytokines. Cytokines are fundamental to regulation of the inflammatory process developing in response to an injury. Certain shifts in their homeostasis may lead to a local or systemic disorder. We compared relative contents of pro- and anti-inflammatory cytokines, along with TGF-β levels in bronchoalveolar lavage (BALF) and blood sera from the patients with stable moderate and severe COPD. It has been shown that increased levels of pro-inflammatory mediators were not counterbalanced by an appropriate up-regulation of anti-inflammatory cytokines, both in BALF and peripheral blood of COPD patients, thus causing their altered interrelations. Comparison of levels of these cytokines in BALF and serum did not reveal any direct correlations, thus suggesting that systemic inflammation is not due to mere overflow of inflammatory mediators from the pulmonary tissue, while assuming some other mechanisms that may determine evolvement of this disorder.E. A. SurkovaN. A. KuzubovaT. P. Ses’Areg A. TotolianSPb RAACIarticlecytokinesinflammationcopdImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 12, Iss 4-5, Pp 349-354 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	cytokines inflammation copd Immunologic diseases. Allergy RC581-607
spellingShingle	cytokines inflammation copd Immunologic diseases. Allergy RC581-607 E. A. Surkova N. A. Kuzubova T. P. Ses’ Areg A. Totolian FEATURES OF CYTOKINE-MEDIATED REGULATION OF FOCAL AND SYSTEMIC INFLAMMATION IN COPD
description	Chronic obstructive pulmonary disease (COPD) is associated with pulmonary and systemic inflammation. The latter is likely to contribute significantly to the pathobiology of numerous extrapulmonary effects of the disease, i.e., systemic effects of COPD. The main causes of systemic inflammation in COPD remain to be elucidated. A course of local vs. systemic inflammation is determined by an imbalance between pro- and anti-inflammatory cytokines. Cytokines are fundamental to regulation of the inflammatory process developing in response to an injury. Certain shifts in their homeostasis may lead to a local or systemic disorder. We compared relative contents of pro- and anti-inflammatory cytokines, along with TGF-β levels in bronchoalveolar lavage (BALF) and blood sera from the patients with stable moderate and severe COPD. It has been shown that increased levels of pro-inflammatory mediators were not counterbalanced by an appropriate up-regulation of anti-inflammatory cytokines, both in BALF and peripheral blood of COPD patients, thus causing their altered interrelations. Comparison of levels of these cytokines in BALF and serum did not reveal any direct correlations, thus suggesting that systemic inflammation is not due to mere overflow of inflammatory mediators from the pulmonary tissue, while assuming some other mechanisms that may determine evolvement of this disorder.
format	article
author	E. A. Surkova N. A. Kuzubova T. P. Ses’ Areg A. Totolian
author_facet	E. A. Surkova N. A. Kuzubova T. P. Ses’ Areg A. Totolian
author_sort	E. A. Surkova
title	FEATURES OF CYTOKINE-MEDIATED REGULATION OF FOCAL AND SYSTEMIC INFLAMMATION IN COPD
title_short	FEATURES OF CYTOKINE-MEDIATED REGULATION OF FOCAL AND SYSTEMIC INFLAMMATION IN COPD
title_full	FEATURES OF CYTOKINE-MEDIATED REGULATION OF FOCAL AND SYSTEMIC INFLAMMATION IN COPD
title_fullStr	FEATURES OF CYTOKINE-MEDIATED REGULATION OF FOCAL AND SYSTEMIC INFLAMMATION IN COPD
title_full_unstemmed	FEATURES OF CYTOKINE-MEDIATED REGULATION OF FOCAL AND SYSTEMIC INFLAMMATION IN COPD
title_sort	features of cytokine-mediated regulation of focal and systemic inflammation in copd
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/c5862be2891146cd9dbaab071026ed4d
work_keys_str_mv	AT easurkova featuresofcytokinemediatedregulationoffocalandsystemicinflammationincopd AT nakuzubova featuresofcytokinemediatedregulationoffocalandsystemicinflammationincopd AT tpses featuresofcytokinemediatedregulationoffocalandsystemicinflammationincopd AT aregatotolian featuresofcytokinemediatedregulationoffocalandsystemicinflammationincopd
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FEATURES OF CYTOKINE-MEDIATED REGULATION OF FOCAL AND SYSTEMIC INFLAMMATION IN COPD

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