Functional insights into aberrant brain responses and integration in patients with lifelong premature ejaculation

Abstract Even though lifelong premature ejaculation (PE) is highly prevalent, few studies have investigated the neural mechanisms underlying PE. The extent and pattern of brain activation can be determined through a version of functional magnetic resonance imaging (fMRI) with erotic picture stimuli...

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Autores principales:	Bing Zhang, Jiaming Lu, Jiadong Xia, Fangfang Wang, Weiping Li, Fei Chen, Youfeng Han, Yun Chen, Bin Zhu, Zhao Qing, Xin Zhang, Yutian Dai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c586c9febd474e0f84173e3ff30320d2
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spelling	oai:doaj.org-article:c586c9febd474e0f84173e3ff30320d22021-12-02T16:06:58ZFunctional insights into aberrant brain responses and integration in patients with lifelong premature ejaculation10.1038/s41598-017-00421-32045-2322https://doaj.org/article/c586c9febd474e0f84173e3ff30320d22017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00421-3https://doaj.org/toc/2045-2322Abstract Even though lifelong premature ejaculation (PE) is highly prevalent, few studies have investigated the neural mechanisms underlying PE. The extent and pattern of brain activation can be determined through a version of functional magnetic resonance imaging (fMRI) with erotic picture stimuli (task fMRI) and a resting-state fMRI (rs fMRI). We showed that the brain activity in the left inferior frontal gyrus and left insula was decreased both during the task and in the resting state, while there was higher activation in the right middle temporal gyrus during the task. Higher functional connectivity was found in PE between those three brain areas and the bilateral middle cingulate cortex, right middle frontal gyrus and supplementary motor area. Moreover, the brain activity had positive correlation with clinical rating scales, such as intravaginal ejaculatory latency time (IELT) and the Chinese Index of Premature Ejaculation (CIPE). These findings revealed that brain responses and functional integration in certain brain areas are impaired in cases of PE, which was consistently supported by multiple measurements obtained using a task and rs fMRI approach.Bing ZhangJiaming LuJiadong XiaFangfang WangWeiping LiFei ChenYoufeng HanYun ChenBin ZhuZhao QingXin ZhangYutian DaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bing Zhang Jiaming Lu Jiadong Xia Fangfang Wang Weiping Li Fei Chen Youfeng Han Yun Chen Bin Zhu Zhao Qing Xin Zhang Yutian Dai Functional insights into aberrant brain responses and integration in patients with lifelong premature ejaculation
description	Abstract Even though lifelong premature ejaculation (PE) is highly prevalent, few studies have investigated the neural mechanisms underlying PE. The extent and pattern of brain activation can be determined through a version of functional magnetic resonance imaging (fMRI) with erotic picture stimuli (task fMRI) and a resting-state fMRI (rs fMRI). We showed that the brain activity in the left inferior frontal gyrus and left insula was decreased both during the task and in the resting state, while there was higher activation in the right middle temporal gyrus during the task. Higher functional connectivity was found in PE between those three brain areas and the bilateral middle cingulate cortex, right middle frontal gyrus and supplementary motor area. Moreover, the brain activity had positive correlation with clinical rating scales, such as intravaginal ejaculatory latency time (IELT) and the Chinese Index of Premature Ejaculation (CIPE). These findings revealed that brain responses and functional integration in certain brain areas are impaired in cases of PE, which was consistently supported by multiple measurements obtained using a task and rs fMRI approach.
format	article
author	Bing Zhang Jiaming Lu Jiadong Xia Fangfang Wang Weiping Li Fei Chen Youfeng Han Yun Chen Bin Zhu Zhao Qing Xin Zhang Yutian Dai
author_facet	Bing Zhang Jiaming Lu Jiadong Xia Fangfang Wang Weiping Li Fei Chen Youfeng Han Yun Chen Bin Zhu Zhao Qing Xin Zhang Yutian Dai
author_sort	Bing Zhang
title	Functional insights into aberrant brain responses and integration in patients with lifelong premature ejaculation
title_short	Functional insights into aberrant brain responses and integration in patients with lifelong premature ejaculation
title_full	Functional insights into aberrant brain responses and integration in patients with lifelong premature ejaculation
title_fullStr	Functional insights into aberrant brain responses and integration in patients with lifelong premature ejaculation
title_full_unstemmed	Functional insights into aberrant brain responses and integration in patients with lifelong premature ejaculation
title_sort	functional insights into aberrant brain responses and integration in patients with lifelong premature ejaculation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c586c9febd474e0f84173e3ff30320d2
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Functional insights into aberrant brain responses and integration in patients with lifelong premature ejaculation

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