Will better evidence on clinical utility bring about greater use of (genetic) tests?

Greater clarity on the nature of clinical utility is desirable. Of itself it may not bring about greater use of tests, including WGS (whole-genome sequencing), not least because clinical utility studies when performed may not confirm predicted changes in patient outcome. The notion that single “pivo...

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Autor principal:	Chris Hyde
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Genetics QH426-470
Acceso en línea:	https://doaj.org/article/c587ebd40d084605972d3dbf4b4dc870
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spelling	oai:doaj.org-article:c587ebd40d084605972d3dbf4b4dc8702021-12-02T11:35:42ZWill better evidence on clinical utility bring about greater use of (genetic) tests?10.1038/s41525-021-00187-82056-7944https://doaj.org/article/c587ebd40d084605972d3dbf4b4dc8702021-03-01T00:00:00Zhttps://doi.org/10.1038/s41525-021-00187-8https://doaj.org/toc/2056-7944Greater clarity on the nature of clinical utility is desirable. Of itself it may not bring about greater use of tests, including WGS (whole-genome sequencing), not least because clinical utility studies when performed may not confirm predicted changes in patient outcome. The notion that single “pivotal” clinical utility studies will achieve uptake needs to be questioned and that the evidence base for tests is likely to rely on patchworks of imperfect evidence embraced.Chris HydeNature PortfolioarticleMedicineRGeneticsQH426-470ENnpj Genomic Medicine, Vol 6, Iss 1, Pp 1-2 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Genetics QH426-470
spellingShingle	Medicine R Genetics QH426-470 Chris Hyde Will better evidence on clinical utility bring about greater use of (genetic) tests?
description	Greater clarity on the nature of clinical utility is desirable. Of itself it may not bring about greater use of tests, including WGS (whole-genome sequencing), not least because clinical utility studies when performed may not confirm predicted changes in patient outcome. The notion that single “pivotal” clinical utility studies will achieve uptake needs to be questioned and that the evidence base for tests is likely to rely on patchworks of imperfect evidence embraced.
format	article
author	Chris Hyde
author_facet	Chris Hyde
author_sort	Chris Hyde
title	Will better evidence on clinical utility bring about greater use of (genetic) tests?
title_short	Will better evidence on clinical utility bring about greater use of (genetic) tests?
title_full	Will better evidence on clinical utility bring about greater use of (genetic) tests?
title_fullStr	Will better evidence on clinical utility bring about greater use of (genetic) tests?
title_full_unstemmed	Will better evidence on clinical utility bring about greater use of (genetic) tests?
title_sort	will better evidence on clinical utility bring about greater use of (genetic) tests?
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c587ebd40d084605972d3dbf4b4dc870
work_keys_str_mv	AT chrishyde willbetterevidenceonclinicalutilitybringaboutgreateruseofgenetictests
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Will better evidence on clinical utility bring about greater use of (genetic) tests?

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