Association of cardiorespiratory fitness and overweight with risk of type 2 diabetes in Japanese men.

<h4>Objective</h4>Existing evidence is limited on what extent fitness can counterbalance type 2 diabetes mellitus (T2DM) risk associated with obesity. We investigated the joint association of weight status and estimated VO2max, a marker of fitness, with the risk of developing T2DM among...

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Autores principales:	Keisuke Kuwahara, Akihiko Uehara, Kayo Kurotani, Ngoc Minh Pham, Akiko Nanri, Makoto Yamamoto, Tetsuya Mizoue
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c589a9907557404fb017e34335364324
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spelling	oai:doaj.org-article:c589a9907557404fb017e343353643242021-11-18T08:17:12ZAssociation of cardiorespiratory fitness and overweight with risk of type 2 diabetes in Japanese men.1932-620310.1371/journal.pone.0098508https://doaj.org/article/c589a9907557404fb017e343353643242014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24896640/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>Existing evidence is limited on what extent fitness can counterbalance type 2 diabetes mellitus (T2DM) risk associated with obesity. We investigated the joint association of weight status and estimated VO2max, a marker of fitness, with the risk of developing T2DM among Japanese men using haemoglobin A1c and fasting glucose criterion.<h4>Methods</h4>The present study included 3,523 male employees aged 18-61 years without diabetes who provided health check-up and fitness data in Japan in 2003-2005. We calculated hazard ratios and 95% confidence intervals for incident diabetes using the Cox regression model.<h4>Results</h4>During a mean follow-up of 6.0 years, 199 men developed diabetes. Multivariable-adjusted hazard ratios (95% confidence interval) of diabetes were 1.00 (reference), 1.44 (1.01-2.07), and 1.48 (1.03-2.13) for the highest through the lowest tertile of fitness (P for trend = 0.04). Additional adjustment for body mass index largely attenuated the association of fitness with diabetes. Joint analysis showed that adjusted hazard ratios of diabetes were 1.00, 1.32, 2.94, and 1.83 in normal weight high-fit men, normal weight low-fit men, overweight high-fit men, and overweight low-fit men, respectively.<h4>Conclusion</h4>The results suggest that weight control is more important than fitness in prevention of type 2 diabetes in Japanese men.Keisuke KuwaharaAkihiko UeharaKayo KurotaniNgoc Minh PhamAkiko NanriMakoto YamamotoTetsuya MizouePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e98508 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Keisuke Kuwahara Akihiko Uehara Kayo Kurotani Ngoc Minh Pham Akiko Nanri Makoto Yamamoto Tetsuya Mizoue Association of cardiorespiratory fitness and overweight with risk of type 2 diabetes in Japanese men.
description	<h4>Objective</h4>Existing evidence is limited on what extent fitness can counterbalance type 2 diabetes mellitus (T2DM) risk associated with obesity. We investigated the joint association of weight status and estimated VO2max, a marker of fitness, with the risk of developing T2DM among Japanese men using haemoglobin A1c and fasting glucose criterion.<h4>Methods</h4>The present study included 3,523 male employees aged 18-61 years without diabetes who provided health check-up and fitness data in Japan in 2003-2005. We calculated hazard ratios and 95% confidence intervals for incident diabetes using the Cox regression model.<h4>Results</h4>During a mean follow-up of 6.0 years, 199 men developed diabetes. Multivariable-adjusted hazard ratios (95% confidence interval) of diabetes were 1.00 (reference), 1.44 (1.01-2.07), and 1.48 (1.03-2.13) for the highest through the lowest tertile of fitness (P for trend = 0.04). Additional adjustment for body mass index largely attenuated the association of fitness with diabetes. Joint analysis showed that adjusted hazard ratios of diabetes were 1.00, 1.32, 2.94, and 1.83 in normal weight high-fit men, normal weight low-fit men, overweight high-fit men, and overweight low-fit men, respectively.<h4>Conclusion</h4>The results suggest that weight control is more important than fitness in prevention of type 2 diabetes in Japanese men.
format	article
author	Keisuke Kuwahara Akihiko Uehara Kayo Kurotani Ngoc Minh Pham Akiko Nanri Makoto Yamamoto Tetsuya Mizoue
author_facet	Keisuke Kuwahara Akihiko Uehara Kayo Kurotani Ngoc Minh Pham Akiko Nanri Makoto Yamamoto Tetsuya Mizoue
author_sort	Keisuke Kuwahara
title	Association of cardiorespiratory fitness and overweight with risk of type 2 diabetes in Japanese men.
title_short	Association of cardiorespiratory fitness and overweight with risk of type 2 diabetes in Japanese men.
title_full	Association of cardiorespiratory fitness and overweight with risk of type 2 diabetes in Japanese men.
title_fullStr	Association of cardiorespiratory fitness and overweight with risk of type 2 diabetes in Japanese men.
title_full_unstemmed	Association of cardiorespiratory fitness and overweight with risk of type 2 diabetes in Japanese men.
title_sort	association of cardiorespiratory fitness and overweight with risk of type 2 diabetes in japanese men.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/c589a9907557404fb017e34335364324
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Association of cardiorespiratory fitness and overweight with risk of type 2 diabetes in Japanese men.

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