Stabilizing Genetically Unstable Simple Sequence Repeats in the <named-content content-type="genus-species">Campylobacter jejuni</named-content> Genome by Multiplex Genome Editing: a Reliable Approach for Delineating Multiple Phase-Variable Genes

Stabilizing Genetically Unstable Simple Sequence Repeats in the <named-content content-type="genus-species">Campylobacter jejuni</named-content> Genome by Multiplex Genome Editing: a Reliable Approach for Delineating Multiple Phase-Variable Genes

ABSTRACT Hypermutable simple sequence repeats (SSRs) are major drivers of phase variation in Campylobacter jejuni. The presence of multiple SSR-mediated phase-variable genes encoding enzymes that modify surface structures, including capsular polysaccharide (CPS) and lipooligosaccharide (LOS), genera...

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Autores principales: Shouji Yamamoto, Sunao Iyoda, Makoto Ohnishi
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2021
Materias:
Campylobacter
genome editing
natural transformation
phase variation
phenotypic engineering
simple sequence repeats
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/c58d0d3b910b4f1b8356db5f23150915
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