Targeting Mannitol Metabolism as an Alternative Antimicrobial Strategy Based on the Structure-Function Study of Mannitol-1-Phosphate Dehydrogenase in <named-content content-type="genus-species">Staphylococcus aureus</named-content>

Targeting Mannitol Metabolism as an Alternative Antimicrobial Strategy Based on the Structure-Function Study of Mannitol-1-Phosphate Dehydrogenase in <named-content content-type="genus-species">Staphylococcus aureus</named-content>

ABSTRACT Mannitol-1-phosphate dehydrogenase (M1PDH) is a key enzyme in Staphylococcus aureus mannitol metabolism, but its roles in pathophysiological settings have not been established. We performed comprehensive structure-function analysis of M1PDH from S. aureus USA300, a strain of community-assoc...

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Autores principales: Thanh Nguyen, Truc Kim, Hai Minh Ta, Won Sik Yeo, Jongkeun Choi, Pushpak Mizar, Seung Seo Lee, Taeok Bae, Akhilesh Kumar Chaurasia, Kyeong Kyu Kim
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2019
Materias:
mannitol-1-phosphate dehydrogenase
Staphylococcus aureus
antibiotic target
antimicrobial resistance
crystal structure
inhibitor
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/c59721ba0d04422397540abf716cd3c0
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