Reactive/Less-cooperative individuals advance population’s synchronization: Modeling of Dictyostelium discoideum concerted signaling during aggregation phase

Orchestrated chemical signaling of single cells sounds to be a linchpin of emerging organization and multicellular life form. The social amoeba Dictyostelium discoideum is a well-studied model organism to explore overall pictures of grouped behavior in developmental biology. The chemical waves secre...

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Autores principales:	Zahra Eidi, Najme Khorasani, Mehdi Sadeghi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c599b58b3de740c9b75b6e1757e0112d
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spelling	oai:doaj.org-article:c599b58b3de740c9b75b6e1757e0112d2021-11-25T06:19:40ZReactive/Less-cooperative individuals advance population’s synchronization: Modeling of Dictyostelium discoideum concerted signaling during aggregation phase1932-6203https://doaj.org/article/c599b58b3de740c9b75b6e1757e0112d2021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601469/?tool=EBIhttps://doaj.org/toc/1932-6203Orchestrated chemical signaling of single cells sounds to be a linchpin of emerging organization and multicellular life form. The social amoeba Dictyostelium discoideum is a well-studied model organism to explore overall pictures of grouped behavior in developmental biology. The chemical waves secreted by aggregating Dictyostelium is a superb example of pattern formation. The waves are either circular or spiral in shape, according to the incremental population density of a self-aggregating community of individuals. Here, we revisit the spatiotemporal patterns that appear in an excitable medium due to synchronization of randomly firing individuals, but with a more parsimonious attitude. According to our model, a fraction of these individuals are less involved in amplifying external stimulants. Our simulations indicate that the cells enhance the system’s asymmetry and as a result, nucleate early sustainable spiral territory zones, provided that their relative population does not exceed a tolerable threshold.Zahra EidiNajme KhorasaniMehdi SadeghiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zahra Eidi Najme Khorasani Mehdi Sadeghi Reactive/Less-cooperative individuals advance population’s synchronization: Modeling of Dictyostelium discoideum concerted signaling during aggregation phase
description	Orchestrated chemical signaling of single cells sounds to be a linchpin of emerging organization and multicellular life form. The social amoeba Dictyostelium discoideum is a well-studied model organism to explore overall pictures of grouped behavior in developmental biology. The chemical waves secreted by aggregating Dictyostelium is a superb example of pattern formation. The waves are either circular or spiral in shape, according to the incremental population density of a self-aggregating community of individuals. Here, we revisit the spatiotemporal patterns that appear in an excitable medium due to synchronization of randomly firing individuals, but with a more parsimonious attitude. According to our model, a fraction of these individuals are less involved in amplifying external stimulants. Our simulations indicate that the cells enhance the system’s asymmetry and as a result, nucleate early sustainable spiral territory zones, provided that their relative population does not exceed a tolerable threshold.
format	article
author	Zahra Eidi Najme Khorasani Mehdi Sadeghi
author_facet	Zahra Eidi Najme Khorasani Mehdi Sadeghi
author_sort	Zahra Eidi
title	Reactive/Less-cooperative individuals advance population’s synchronization: Modeling of Dictyostelium discoideum concerted signaling during aggregation phase
title_short	Reactive/Less-cooperative individuals advance population’s synchronization: Modeling of Dictyostelium discoideum concerted signaling during aggregation phase
title_full	Reactive/Less-cooperative individuals advance population’s synchronization: Modeling of Dictyostelium discoideum concerted signaling during aggregation phase
title_fullStr	Reactive/Less-cooperative individuals advance population’s synchronization: Modeling of Dictyostelium discoideum concerted signaling during aggregation phase
title_full_unstemmed	Reactive/Less-cooperative individuals advance population’s synchronization: Modeling of Dictyostelium discoideum concerted signaling during aggregation phase
title_sort	reactive/less-cooperative individuals advance population’s synchronization: modeling of dictyostelium discoideum concerted signaling during aggregation phase
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/c599b58b3de740c9b75b6e1757e0112d
work_keys_str_mv	AT zahraeidi reactivelesscooperativeindividualsadvancepopulationssynchronizationmodelingofdictyosteliumdiscoideumconcertedsignalingduringaggregationphase AT najmekhorasani reactivelesscooperativeindividualsadvancepopulationssynchronizationmodelingofdictyosteliumdiscoideumconcertedsignalingduringaggregationphase AT mehdisadeghi reactivelesscooperativeindividualsadvancepopulationssynchronizationmodelingofdictyosteliumdiscoideumconcertedsignalingduringaggregationphase
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Reactive/Less-cooperative individuals advance population’s synchronization: Modeling of Dictyostelium discoideum concerted signaling during aggregation phase

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