ROLE OF THE CELLULAR IMMUNITY IN THE PATHOGENESIS OF BRAIN CONTUSION

Traumatic brain injury (TBI) is one of the most common pathologies of the central nervous system in the world, and the use of structural neuroimaging methods – computed tomography (CT) and magnetic resonance imaging (MRI) – often doesn’t allow assessment of the severity of the brain injury that has...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	A. O. Norka, S. V. Vorobyev, R. N. Kuznetsova, M. K. Serebriakova, I. V. Kudryavtsev, S. N. Kovalenko
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2021
Materias:	traumatic brain injury (tbi) flow cytometry contusion inflammatory cellular immune status subpopulations of cd3+cd4+-lymphocytes Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/c59c0f9815514401958c345a52ae4cfe
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c59c0f9815514401958c345a52ae4cfe
record_format	dspace
spelling	oai:doaj.org-article:c59c0f9815514401958c345a52ae4cfe2021-11-18T08:03:51ZROLE OF THE CELLULAR IMMUNITY IN THE PATHOGENESIS OF BRAIN CONTUSION1563-06252313-741X10.15789/1563-0625-ROT-2355https://doaj.org/article/c59c0f9815514401958c345a52ae4cfe2021-10-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/2425https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XTraumatic brain injury (TBI) is one of the most common pathologies of the central nervous system in the world, and the use of structural neuroimaging methods – computed tomography (CT) and magnetic resonance imaging (MRI) – often doesn’t allow assessment of the severity of the brain injury that has occurred. This situation predetermines the need to search for new methods of differential diagnosis of the severity of TBI and predicting the risk of consequences.One of these promising areas is the study of the immune status, since traumatic brain injury is characterized by a high rate of complications.One of these promising areas is the study of the immune status in patients with TBI in the acute period. It is now known that in response to brain damage, a response from the immune system is triggered.The reactions from the immune system, which develop after brain injury and directed against its own antigens, in the early period of the disease are related to damage to the nervous tissue. However, according to the latest available data, they are subsequently able to stimulate the processes of repair and regeneration in the brain tissue. In the course of damage to the nervous tissue, in response to endogenous molecules formed during the destruction of cells and the extracellular matrix, the cells of the immune system are activated.Current evidence indicates that T-cells play a role in both the formation of secondary damage and repair mechanisms. They are able to protect neurons through the production of neurotrophic factors such as brain neurotrophic factor (BDNF), which stimulates the growth of neurons, the formation of synapses.Using multicolor cytometric analysis within the framework of this work, a study was carried out to determine the number of the main subpopulations of CD3+CD4+-lymphocytes. The relative number of Th17 (CXCR5- CXCR3- CCR6+CCR4- ) and Th17/Th22 (CXCR5- CXCR3- CCR6+CCR4+), Th1/Th17 (CXCR5- CXCR3+CCR6+CCR4- ) among total CD45RA-negative CD3+CD4+-cells population is significantly increased in comparison with the values in the control group, in turn, the Th1(CXCR5- CXCR3+CCR6- CCR4- ) subpopulations among total CD45RA-negative CD3+CD4+-cells are significantly decreased with the values in the control group. The results obtained so far make it possible to consider immune responses among the key links in the pathogenesis of brain contusion TBI. And, perhaps, a comprehensive immunological examination of the victims in the first day after the injury will determine the parameters that will help predict the nature of possible complications in patients with brain contusion.A. O. NorkaS. V. VorobyevR. N. KuznetsovaM. K. SerebriakovaI. V. KudryavtsevS. N. KovalenkoSPb RAACIarticletraumatic brain injury (tbi)flow cytometrycontusioninflammatorycellular immune statussubpopulations of cd3+cd4+-lymphocytesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 23, Iss 4, Pp 825-830 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	traumatic brain injury (tbi) flow cytometry contusion inflammatory cellular immune status subpopulations of cd3+cd4+-lymphocytes Immunologic diseases. Allergy RC581-607
spellingShingle	traumatic brain injury (tbi) flow cytometry contusion inflammatory cellular immune status subpopulations of cd3+cd4+-lymphocytes Immunologic diseases. Allergy RC581-607 A. O. Norka S. V. Vorobyev R. N. Kuznetsova M. K. Serebriakova I. V. Kudryavtsev S. N. Kovalenko ROLE OF THE CELLULAR IMMUNITY IN THE PATHOGENESIS OF BRAIN CONTUSION
description	Traumatic brain injury (TBI) is one of the most common pathologies of the central nervous system in the world, and the use of structural neuroimaging methods – computed tomography (CT) and magnetic resonance imaging (MRI) – often doesn’t allow assessment of the severity of the brain injury that has occurred. This situation predetermines the need to search for new methods of differential diagnosis of the severity of TBI and predicting the risk of consequences.One of these promising areas is the study of the immune status, since traumatic brain injury is characterized by a high rate of complications.One of these promising areas is the study of the immune status in patients with TBI in the acute period. It is now known that in response to brain damage, a response from the immune system is triggered.The reactions from the immune system, which develop after brain injury and directed against its own antigens, in the early period of the disease are related to damage to the nervous tissue. However, according to the latest available data, they are subsequently able to stimulate the processes of repair and regeneration in the brain tissue. In the course of damage to the nervous tissue, in response to endogenous molecules formed during the destruction of cells and the extracellular matrix, the cells of the immune system are activated.Current evidence indicates that T-cells play a role in both the formation of secondary damage and repair mechanisms. They are able to protect neurons through the production of neurotrophic factors such as brain neurotrophic factor (BDNF), which stimulates the growth of neurons, the formation of synapses.Using multicolor cytometric analysis within the framework of this work, a study was carried out to determine the number of the main subpopulations of CD3+CD4+-lymphocytes. The relative number of Th17 (CXCR5- CXCR3- CCR6+CCR4- ) and Th17/Th22 (CXCR5- CXCR3- CCR6+CCR4+), Th1/Th17 (CXCR5- CXCR3+CCR6+CCR4- ) among total CD45RA-negative CD3+CD4+-cells population is significantly increased in comparison with the values in the control group, in turn, the Th1(CXCR5- CXCR3+CCR6- CCR4- ) subpopulations among total CD45RA-negative CD3+CD4+-cells are significantly decreased with the values in the control group. The results obtained so far make it possible to consider immune responses among the key links in the pathogenesis of brain contusion TBI. And, perhaps, a comprehensive immunological examination of the victims in the first day after the injury will determine the parameters that will help predict the nature of possible complications in patients with brain contusion.
format	article
author	A. O. Norka S. V. Vorobyev R. N. Kuznetsova M. K. Serebriakova I. V. Kudryavtsev S. N. Kovalenko
author_facet	A. O. Norka S. V. Vorobyev R. N. Kuznetsova M. K. Serebriakova I. V. Kudryavtsev S. N. Kovalenko
author_sort	A. O. Norka
title	ROLE OF THE CELLULAR IMMUNITY IN THE PATHOGENESIS OF BRAIN CONTUSION
title_short	ROLE OF THE CELLULAR IMMUNITY IN THE PATHOGENESIS OF BRAIN CONTUSION
title_full	ROLE OF THE CELLULAR IMMUNITY IN THE PATHOGENESIS OF BRAIN CONTUSION
title_fullStr	ROLE OF THE CELLULAR IMMUNITY IN THE PATHOGENESIS OF BRAIN CONTUSION
title_full_unstemmed	ROLE OF THE CELLULAR IMMUNITY IN THE PATHOGENESIS OF BRAIN CONTUSION
title_sort	role of the cellular immunity in the pathogenesis of brain contusion
publisher	SPb RAACI
publishDate	2021
url	https://doaj.org/article/c59c0f9815514401958c345a52ae4cfe
work_keys_str_mv	AT aonorka roleofthecellularimmunityinthepathogenesisofbraincontusion AT svvorobyev roleofthecellularimmunityinthepathogenesisofbraincontusion AT rnkuznetsova roleofthecellularimmunityinthepathogenesisofbraincontusion AT mkserebriakova roleofthecellularimmunityinthepathogenesisofbraincontusion AT ivkudryavtsev roleofthecellularimmunityinthepathogenesisofbraincontusion AT snkovalenko roleofthecellularimmunityinthepathogenesisofbraincontusion
_version_	1718422313185050624

ROLE OF THE CELLULAR IMMUNITY IN THE PATHOGENESIS OF BRAIN CONTUSION

Ejemplares similares