Diagnostic capability of Pulsar perimetry in pre-perimetric and early glaucoma

Abstract This study aimed to compare the diagnostic capability of Pulsar perimetry (Pulsar) in pre-perimetric glaucoma (PPG) and early glaucoma (EG) with that of Flicker perimetry (Flicker) and spectral-domain optical conference tomography (SD-OCT). This prospective cross-sectional study included 25...

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Autores principales:	Kazunori Hirasawa, Natsumi Takahashi, Kazuhiro Matsumura, Masayuki Kasahara, Nobuyuki Shoji
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c59dbea343784d34945990e395cf5919
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spelling	oai:doaj.org-article:c59dbea343784d34945990e395cf59192021-12-02T12:32:45ZDiagnostic capability of Pulsar perimetry in pre-perimetric and early glaucoma10.1038/s41598-017-03550-x2045-2322https://doaj.org/article/c59dbea343784d34945990e395cf59192017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03550-xhttps://doaj.org/toc/2045-2322Abstract This study aimed to compare the diagnostic capability of Pulsar perimetry (Pulsar) in pre-perimetric glaucoma (PPG) and early glaucoma (EG) with that of Flicker perimetry (Flicker) and spectral-domain optical conference tomography (SD-OCT). This prospective cross-sectional study included 25 eyes of 25 PPG patients, 35 eyes of 35 EG patients, and 42 eyes of 42 healthy participants. The diagnostic capability using the area under the curve (AUC) of the best parameter and agreement of detectability between structural and functional measurements were compared. For PPG patients, the AUC of Pulsar, Flicker, OCT-disc, and OCT-macular was 0.733, 0.663, 0.842, and 0.780, respectively. The AUC of Flicker was significantly lower than that of OCT-disc (p = 0.016). For EG patients, the AUC of Pulsar, Flicker, OCT-disc, and OCT-macular were 0.851, 0.869, 0.907, and 0.861, respectively. There was no significant difference in AUC among these methods. The agreement between structural and functional measurements expressed by kappa value ranged from −0.16 to 0.07 for PPG and from 0.01 to 0.25 for EG. Although the diagnostic capability of Pulsar in the PPG and EG groups was equal to that of Flicker and SD-OCT, the agreements between structural and functional measurements for both PPG and EG were poor.Kazunori HirasawaNatsumi TakahashiKazuhiro MatsumuraMasayuki KasaharaNobuyuki ShojiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kazunori Hirasawa Natsumi Takahashi Kazuhiro Matsumura Masayuki Kasahara Nobuyuki Shoji Diagnostic capability of Pulsar perimetry in pre-perimetric and early glaucoma
description	Abstract This study aimed to compare the diagnostic capability of Pulsar perimetry (Pulsar) in pre-perimetric glaucoma (PPG) and early glaucoma (EG) with that of Flicker perimetry (Flicker) and spectral-domain optical conference tomography (SD-OCT). This prospective cross-sectional study included 25 eyes of 25 PPG patients, 35 eyes of 35 EG patients, and 42 eyes of 42 healthy participants. The diagnostic capability using the area under the curve (AUC) of the best parameter and agreement of detectability between structural and functional measurements were compared. For PPG patients, the AUC of Pulsar, Flicker, OCT-disc, and OCT-macular was 0.733, 0.663, 0.842, and 0.780, respectively. The AUC of Flicker was significantly lower than that of OCT-disc (p = 0.016). For EG patients, the AUC of Pulsar, Flicker, OCT-disc, and OCT-macular were 0.851, 0.869, 0.907, and 0.861, respectively. There was no significant difference in AUC among these methods. The agreement between structural and functional measurements expressed by kappa value ranged from −0.16 to 0.07 for PPG and from 0.01 to 0.25 for EG. Although the diagnostic capability of Pulsar in the PPG and EG groups was equal to that of Flicker and SD-OCT, the agreements between structural and functional measurements for both PPG and EG were poor.
format	article
author	Kazunori Hirasawa Natsumi Takahashi Kazuhiro Matsumura Masayuki Kasahara Nobuyuki Shoji
author_facet	Kazunori Hirasawa Natsumi Takahashi Kazuhiro Matsumura Masayuki Kasahara Nobuyuki Shoji
author_sort	Kazunori Hirasawa
title	Diagnostic capability of Pulsar perimetry in pre-perimetric and early glaucoma
title_short	Diagnostic capability of Pulsar perimetry in pre-perimetric and early glaucoma
title_full	Diagnostic capability of Pulsar perimetry in pre-perimetric and early glaucoma
title_fullStr	Diagnostic capability of Pulsar perimetry in pre-perimetric and early glaucoma
title_full_unstemmed	Diagnostic capability of Pulsar perimetry in pre-perimetric and early glaucoma
title_sort	diagnostic capability of pulsar perimetry in pre-perimetric and early glaucoma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c59dbea343784d34945990e395cf5919
work_keys_str_mv	AT kazunorihirasawa diagnosticcapabilityofpulsarperimetryinpreperimetricandearlyglaucoma AT natsumitakahashi diagnosticcapabilityofpulsarperimetryinpreperimetricandearlyglaucoma AT kazuhiromatsumura diagnosticcapabilityofpulsarperimetryinpreperimetricandearlyglaucoma AT masayukikasahara diagnosticcapabilityofpulsarperimetryinpreperimetricandearlyglaucoma AT nobuyukishoji diagnosticcapabilityofpulsarperimetryinpreperimetricandearlyglaucoma
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Diagnostic capability of Pulsar perimetry in pre-perimetric and early glaucoma

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