Potassium starvation in yeast: mechanisms of homeostasis revealed by mathematical modeling.

The intrinsic ability of cells to adapt to a wide range of environmental conditions is a fundamental process required for survival. Potassium is the most abundant cation in living cells and is required for essential cellular processes, including the regulation of cell volume, pH and protein synthesi...

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Autores principales:	Matthias Kahm, Clara Navarrete, Vicent Llopis-Torregrosa, Rito Herrera, Lina Barreto, Lynne Yenush, Joaquin Ariño, Jose Ramos, Maik Kschischo
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c59e14053e8f46b1ab6aa2f10f6822cb
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spelling	oai:doaj.org-article:c59e14053e8f46b1ab6aa2f10f6822cb2021-11-18T05:51:14ZPotassium starvation in yeast: mechanisms of homeostasis revealed by mathematical modeling.1553-734X1553-735810.1371/journal.pcbi.1002548https://doaj.org/article/c59e14053e8f46b1ab6aa2f10f6822cb2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22737060/pdf/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358The intrinsic ability of cells to adapt to a wide range of environmental conditions is a fundamental process required for survival. Potassium is the most abundant cation in living cells and is required for essential cellular processes, including the regulation of cell volume, pH and protein synthesis. Yeast cells can grow from low micromolar to molar potassium concentrations and utilize sophisticated control mechanisms to keep the internal potassium concentration in a viable range. We developed a mathematical model for Saccharomyces cerevisiae to explore the complex interplay between biophysical forces and molecular regulation facilitating potassium homeostasis. By using a novel inference method ("the reverse tracking algorithm") we predicted and then verified experimentally that the main regulators under conditions of potassium starvation are proton fluxes responding to changes of potassium concentrations. In contrast to the prevailing view, we show that regulation of the main potassium transport systems (Trk1,2 and Nha1) in the plasma membrane is not sufficient to achieve homeostasis.Matthias KahmClara NavarreteVicent Llopis-TorregrosaRito HerreraLina BarretoLynne YenushJoaquin AriñoJose RamosMaik KschischoPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 8, Iss 6, p e1002548 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Matthias Kahm Clara Navarrete Vicent Llopis-Torregrosa Rito Herrera Lina Barreto Lynne Yenush Joaquin Ariño Jose Ramos Maik Kschischo Potassium starvation in yeast: mechanisms of homeostasis revealed by mathematical modeling.
description	The intrinsic ability of cells to adapt to a wide range of environmental conditions is a fundamental process required for survival. Potassium is the most abundant cation in living cells and is required for essential cellular processes, including the regulation of cell volume, pH and protein synthesis. Yeast cells can grow from low micromolar to molar potassium concentrations and utilize sophisticated control mechanisms to keep the internal potassium concentration in a viable range. We developed a mathematical model for Saccharomyces cerevisiae to explore the complex interplay between biophysical forces and molecular regulation facilitating potassium homeostasis. By using a novel inference method ("the reverse tracking algorithm") we predicted and then verified experimentally that the main regulators under conditions of potassium starvation are proton fluxes responding to changes of potassium concentrations. In contrast to the prevailing view, we show that regulation of the main potassium transport systems (Trk1,2 and Nha1) in the plasma membrane is not sufficient to achieve homeostasis.
format	article
author	Matthias Kahm Clara Navarrete Vicent Llopis-Torregrosa Rito Herrera Lina Barreto Lynne Yenush Joaquin Ariño Jose Ramos Maik Kschischo
author_facet	Matthias Kahm Clara Navarrete Vicent Llopis-Torregrosa Rito Herrera Lina Barreto Lynne Yenush Joaquin Ariño Jose Ramos Maik Kschischo
author_sort	Matthias Kahm
title	Potassium starvation in yeast: mechanisms of homeostasis revealed by mathematical modeling.
title_short	Potassium starvation in yeast: mechanisms of homeostasis revealed by mathematical modeling.
title_full	Potassium starvation in yeast: mechanisms of homeostasis revealed by mathematical modeling.
title_fullStr	Potassium starvation in yeast: mechanisms of homeostasis revealed by mathematical modeling.
title_full_unstemmed	Potassium starvation in yeast: mechanisms of homeostasis revealed by mathematical modeling.
title_sort	potassium starvation in yeast: mechanisms of homeostasis revealed by mathematical modeling.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/c59e14053e8f46b1ab6aa2f10f6822cb
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Potassium starvation in yeast: mechanisms of homeostasis revealed by mathematical modeling.

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