Ex vivo pretreatment of human vessels with siRNA nanoparticles provides protein silencing in endothelial cells

The use of gene silencing techniques in the treatment of post-transplantation host rejection is not long lasting and can have systemic effects. Here, the authors utilize a nanocarrier for siRNA for treatment of arteries ex vivo prior to implantation subsequently attenuating immune reaction in vivo.

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Autores principales:	Jiajia Cui, Lingfeng Qin, Junwei Zhang, Parwiz Abrahimi, Hong Li, Guangxin Li, Gregory T. Tietjen, George Tellides, Jordan S. Pober, W. Mark Saltzman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c59f9b48811d4c04a1ab80ce962fe280
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spelling	oai:doaj.org-article:c59f9b48811d4c04a1ab80ce962fe2802021-12-02T13:57:33ZEx vivo pretreatment of human vessels with siRNA nanoparticles provides protein silencing in endothelial cells10.1038/s41467-017-00297-x2041-1723https://doaj.org/article/c59f9b48811d4c04a1ab80ce962fe2802017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00297-xhttps://doaj.org/toc/2041-1723The use of gene silencing techniques in the treatment of post-transplantation host rejection is not long lasting and can have systemic effects. Here, the authors utilize a nanocarrier for siRNA for treatment of arteries ex vivo prior to implantation subsequently attenuating immune reaction in vivo.Jiajia CuiLingfeng QinJunwei ZhangParwiz AbrahimiHong LiGuangxin LiGregory T. TietjenGeorge TellidesJordan S. PoberW. Mark SaltzmanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jiajia Cui Lingfeng Qin Junwei Zhang Parwiz Abrahimi Hong Li Guangxin Li Gregory T. Tietjen George Tellides Jordan S. Pober W. Mark Saltzman Ex vivo pretreatment of human vessels with siRNA nanoparticles provides protein silencing in endothelial cells
description	The use of gene silencing techniques in the treatment of post-transplantation host rejection is not long lasting and can have systemic effects. Here, the authors utilize a nanocarrier for siRNA for treatment of arteries ex vivo prior to implantation subsequently attenuating immune reaction in vivo.
format	article
author	Jiajia Cui Lingfeng Qin Junwei Zhang Parwiz Abrahimi Hong Li Guangxin Li Gregory T. Tietjen George Tellides Jordan S. Pober W. Mark Saltzman
author_facet	Jiajia Cui Lingfeng Qin Junwei Zhang Parwiz Abrahimi Hong Li Guangxin Li Gregory T. Tietjen George Tellides Jordan S. Pober W. Mark Saltzman
author_sort	Jiajia Cui
title	Ex vivo pretreatment of human vessels with siRNA nanoparticles provides protein silencing in endothelial cells
title_short	Ex vivo pretreatment of human vessels with siRNA nanoparticles provides protein silencing in endothelial cells
title_full	Ex vivo pretreatment of human vessels with siRNA nanoparticles provides protein silencing in endothelial cells
title_fullStr	Ex vivo pretreatment of human vessels with siRNA nanoparticles provides protein silencing in endothelial cells
title_full_unstemmed	Ex vivo pretreatment of human vessels with siRNA nanoparticles provides protein silencing in endothelial cells
title_sort	ex vivo pretreatment of human vessels with sirna nanoparticles provides protein silencing in endothelial cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c59f9b48811d4c04a1ab80ce962fe280
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Ex vivo pretreatment of human vessels with siRNA nanoparticles provides protein silencing in endothelial cells

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