Biochemical and haematological enhancement activities of aqueous and methanol leaves, stem and roots extracts of Chasmanthera dependens (Hochst) and Dictyandra arborescens (Welw.)

Abstract Background Africa is blessed with rich floral biodiversity which are harnessed as herbal medicines and remedies for several ailments. Since there has been evidence of organ toxicity following prolonged ingestion of medicinal plant concotions, this study investigated the biochemical and hema...

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Autores principales:	Uchechi E. Enenebeaku, Evangeline N. Okotcha, Lilian M. O. Oguoma, Ifeyinwa C. Mgbemena, Conrad K. Enenebeaku, Chiemeziem A. Onyeka
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Chasmanathera dependens Dictyandra arborescens Biochemical Haematological Acute and sub acute toxicity Science Q
Acceso en línea:	https://doaj.org/article/c5a066706da84b6bacddc1ce3ac95239
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spelling	oai:doaj.org-article:c5a066706da84b6bacddc1ce3ac952392021-11-08T11:13:07ZBiochemical and haematological enhancement activities of aqueous and methanol leaves, stem and roots extracts of Chasmanthera dependens (Hochst) and Dictyandra arborescens (Welw.)10.1186/s42269-021-00642-72522-8307https://doaj.org/article/c5a066706da84b6bacddc1ce3ac952392021-11-01T00:00:00Zhttps://doi.org/10.1186/s42269-021-00642-7https://doaj.org/toc/2522-8307Abstract Background Africa is blessed with rich floral biodiversity which are harnessed as herbal medicines and remedies for several ailments. Since there has been evidence of organ toxicity following prolonged ingestion of medicinal plant concotions, this study investigated the biochemical and hematological enhancement activities of aqueous and methanolic leaves, stem and roots extracts of Chasmanthera dependens (Hochst) and Dictyandra arborescens (Welw) in adult male albino rats. Results Leaves, stem and roots extracts of D. arborescens, as well as extracts of leaves and roots of C. dependens did not record any mice mortality even at 5000 mg/kg b.wt but extracts of C. dependens stem in both medium recorded death at 2900 mg/kg b. wt and 5000 mg/kg b.wt. Ingestion of the extracts by rats over a 14-day period increased (p < 0.05) the body weights of the experimental animals in the C. dependens and D. arborescens treated groups. The relative organ weights of rats that received the extracts did not differ (p < 0.05) significantly from those of the standard and normal control. Administration of the extracts revealed significant (p < 0.05) increase in haematological parameters (PCV, Hb, RBCs, WBCs, MCH, Neutrophils, Lymphocytes and MCHC) at 200 mg/kg−1 body weight. For biochemical parameters, levels of ALT, AST, ALP, total protein, and albumin were not significantly (p < 0.05) elevated following administration of the extracts. Conclusion These parameters did not differ significantly from the normal and standard control. Since these extracts did not exhibit any chronic toxicity on experimental animals, suggesting no harmful effects following their use, their continuous use in ethno-medicine is therefore justified.Uchechi E. EnenebeakuEvangeline N. OkotchaLilian M. O. OguomaIfeyinwa C. MgbemenaConrad K. EnenebeakuChiemeziem A. OnyekaSpringerOpenarticleChasmanathera dependensDictyandra arborescensBiochemicalHaematologicalAcute and sub acute toxicityScienceQENBulletin of the National Research Centre, Vol 45, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chasmanathera dependens Dictyandra arborescens Biochemical Haematological Acute and sub acute toxicity Science Q
spellingShingle	Chasmanathera dependens Dictyandra arborescens Biochemical Haematological Acute and sub acute toxicity Science Q Uchechi E. Enenebeaku Evangeline N. Okotcha Lilian M. O. Oguoma Ifeyinwa C. Mgbemena Conrad K. Enenebeaku Chiemeziem A. Onyeka Biochemical and haematological enhancement activities of aqueous and methanol leaves, stem and roots extracts of Chasmanthera dependens (Hochst) and Dictyandra arborescens (Welw.)
description	Abstract Background Africa is blessed with rich floral biodiversity which are harnessed as herbal medicines and remedies for several ailments. Since there has been evidence of organ toxicity following prolonged ingestion of medicinal plant concotions, this study investigated the biochemical and hematological enhancement activities of aqueous and methanolic leaves, stem and roots extracts of Chasmanthera dependens (Hochst) and Dictyandra arborescens (Welw) in adult male albino rats. Results Leaves, stem and roots extracts of D. arborescens, as well as extracts of leaves and roots of C. dependens did not record any mice mortality even at 5000 mg/kg b.wt but extracts of C. dependens stem in both medium recorded death at 2900 mg/kg b. wt and 5000 mg/kg b.wt. Ingestion of the extracts by rats over a 14-day period increased (p < 0.05) the body weights of the experimental animals in the C. dependens and D. arborescens treated groups. The relative organ weights of rats that received the extracts did not differ (p < 0.05) significantly from those of the standard and normal control. Administration of the extracts revealed significant (p < 0.05) increase in haematological parameters (PCV, Hb, RBCs, WBCs, MCH, Neutrophils, Lymphocytes and MCHC) at 200 mg/kg−1 body weight. For biochemical parameters, levels of ALT, AST, ALP, total protein, and albumin were not significantly (p < 0.05) elevated following administration of the extracts. Conclusion These parameters did not differ significantly from the normal and standard control. Since these extracts did not exhibit any chronic toxicity on experimental animals, suggesting no harmful effects following their use, their continuous use in ethno-medicine is therefore justified.
format	article
author	Uchechi E. Enenebeaku Evangeline N. Okotcha Lilian M. O. Oguoma Ifeyinwa C. Mgbemena Conrad K. Enenebeaku Chiemeziem A. Onyeka
author_facet	Uchechi E. Enenebeaku Evangeline N. Okotcha Lilian M. O. Oguoma Ifeyinwa C. Mgbemena Conrad K. Enenebeaku Chiemeziem A. Onyeka
author_sort	Uchechi E. Enenebeaku
title	Biochemical and haematological enhancement activities of aqueous and methanol leaves, stem and roots extracts of Chasmanthera dependens (Hochst) and Dictyandra arborescens (Welw.)
title_short	Biochemical and haematological enhancement activities of aqueous and methanol leaves, stem and roots extracts of Chasmanthera dependens (Hochst) and Dictyandra arborescens (Welw.)
title_full	Biochemical and haematological enhancement activities of aqueous and methanol leaves, stem and roots extracts of Chasmanthera dependens (Hochst) and Dictyandra arborescens (Welw.)
title_fullStr	Biochemical and haematological enhancement activities of aqueous and methanol leaves, stem and roots extracts of Chasmanthera dependens (Hochst) and Dictyandra arborescens (Welw.)
title_full_unstemmed	Biochemical and haematological enhancement activities of aqueous and methanol leaves, stem and roots extracts of Chasmanthera dependens (Hochst) and Dictyandra arborescens (Welw.)
title_sort	biochemical and haematological enhancement activities of aqueous and methanol leaves, stem and roots extracts of chasmanthera dependens (hochst) and dictyandra arborescens (welw.)
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/c5a066706da84b6bacddc1ce3ac95239
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Biochemical and haematological enhancement activities of aqueous and methanol leaves, stem and roots extracts of Chasmanthera dependens (Hochst) and Dictyandra arborescens (Welw.)

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