CDK1 phosphorylates WRN at collapsed replication forks

End-resection of double strand DNA breaks is essential for pathway choice between non-homologous end-joining and homologous recombination. Here the authors show that phosphorylation of WRN helicase by CDK1 is essential for resection at replication-related breaks.

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Autores principales:	Valentina Palermo, Sara Rinalducci, Massimo Sanchez, Francesca Grillini, Joshua A. Sommers, Robert M. Brosh, Lello Zolla, Annapaola Franchitto, Pietro Pichierri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c5a07e25c5d84b82a2f6c7c01fa3ba7f
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spelling	oai:doaj.org-article:c5a07e25c5d84b82a2f6c7c01fa3ba7f2021-12-02T16:50:56ZCDK1 phosphorylates WRN at collapsed replication forks10.1038/ncomms128802041-1723https://doaj.org/article/c5a07e25c5d84b82a2f6c7c01fa3ba7f2016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12880https://doaj.org/toc/2041-1723End-resection of double strand DNA breaks is essential for pathway choice between non-homologous end-joining and homologous recombination. Here the authors show that phosphorylation of WRN helicase by CDK1 is essential for resection at replication-related breaks.Valentina PalermoSara RinalducciMassimo SanchezFrancesca GrilliniJoshua A. SommersRobert M. BroshLello ZollaAnnapaola FranchittoPietro PichierriNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Valentina Palermo Sara Rinalducci Massimo Sanchez Francesca Grillini Joshua A. Sommers Robert M. Brosh Lello Zolla Annapaola Franchitto Pietro Pichierri CDK1 phosphorylates WRN at collapsed replication forks
description	End-resection of double strand DNA breaks is essential for pathway choice between non-homologous end-joining and homologous recombination. Here the authors show that phosphorylation of WRN helicase by CDK1 is essential for resection at replication-related breaks.
format	article
author	Valentina Palermo Sara Rinalducci Massimo Sanchez Francesca Grillini Joshua A. Sommers Robert M. Brosh Lello Zolla Annapaola Franchitto Pietro Pichierri
author_facet	Valentina Palermo Sara Rinalducci Massimo Sanchez Francesca Grillini Joshua A. Sommers Robert M. Brosh Lello Zolla Annapaola Franchitto Pietro Pichierri
author_sort	Valentina Palermo
title	CDK1 phosphorylates WRN at collapsed replication forks
title_short	CDK1 phosphorylates WRN at collapsed replication forks
title_full	CDK1 phosphorylates WRN at collapsed replication forks
title_fullStr	CDK1 phosphorylates WRN at collapsed replication forks
title_full_unstemmed	CDK1 phosphorylates WRN at collapsed replication forks
title_sort	cdk1 phosphorylates wrn at collapsed replication forks
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/c5a07e25c5d84b82a2f6c7c01fa3ba7f
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CDK1 phosphorylates WRN at collapsed replication forks

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