CDK1 phosphorylates WRN at collapsed replication forks

CDK1 phosphorylates WRN at collapsed replication forks

End-resection of double strand DNA breaks is essential for pathway choice between non-homologous end-joining and homologous recombination. Here the authors show that phosphorylation of WRN helicase by CDK1 is essential for resection at replication-related breaks.

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Autores principales: Valentina Palermo, Sara Rinalducci, Massimo Sanchez, Francesca Grillini, Joshua A. Sommers, Robert M. Brosh, Lello Zolla, Annapaola Franchitto, Pietro Pichierri
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/c5a07e25c5d84b82a2f6c7c01fa3ba7f
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