<italic toggle="yes">Vibrio cholerae</italic> at the Intersection of Immunity and the Microbiome

ABSTRACT Vibrio cholerae is a noninvasive pathogen that colonizes the small intestine and produces cholera toxin, causing severe secretory diarrhea. Cholera results in long lasting immunity, and recent studies have improved our understanding of the antigenic repertoire of V. cholerae. Interactions b...

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Autores principales:	Ana A. Weil, Rachel L. Becker, Jason B. Harris
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	Vibrio cholerae cholera immune response innate immunity microbiome vaccine Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/c5a3f0360f2347e2aeddf5972924b098
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spelling	oai:doaj.org-article:c5a3f0360f2347e2aeddf5972924b0982021-11-15T15:22:24Z<italic toggle="yes">Vibrio cholerae</italic> at the Intersection of Immunity and the Microbiome10.1128/mSphere.00597-192379-5042https://doaj.org/article/c5a3f0360f2347e2aeddf5972924b0982019-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00597-19https://doaj.org/toc/2379-5042ABSTRACT Vibrio cholerae is a noninvasive pathogen that colonizes the small intestine and produces cholera toxin, causing severe secretory diarrhea. Cholera results in long lasting immunity, and recent studies have improved our understanding of the antigenic repertoire of V. cholerae. Interactions between the host, V. cholerae, and the intestinal microbiome are now recognized as factors which impact susceptibility to cholera and the ability to mount a successful immune response to vaccination. Here, we review recent data and corresponding models to describe immune responses to V. cholerae infection and explain how the host microbiome may impact the pathogenesis of V. cholerae. In the ongoing battle against cholera, the intestinal microbiome represents a frontier for new approaches to intervention and prevention.Ana A. WeilRachel L. BeckerJason B. HarrisAmerican Society for MicrobiologyarticleVibrio choleraecholeraimmune responseinnate immunitymicrobiomevaccineMicrobiologyQR1-502ENmSphere, Vol 4, Iss 6 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Vibrio cholerae cholera immune response innate immunity microbiome vaccine Microbiology QR1-502
spellingShingle	Vibrio cholerae cholera immune response innate immunity microbiome vaccine Microbiology QR1-502 Ana A. Weil Rachel L. Becker Jason B. Harris <italic toggle="yes">Vibrio cholerae</italic> at the Intersection of Immunity and the Microbiome
description	ABSTRACT Vibrio cholerae is a noninvasive pathogen that colonizes the small intestine and produces cholera toxin, causing severe secretory diarrhea. Cholera results in long lasting immunity, and recent studies have improved our understanding of the antigenic repertoire of V. cholerae. Interactions between the host, V. cholerae, and the intestinal microbiome are now recognized as factors which impact susceptibility to cholera and the ability to mount a successful immune response to vaccination. Here, we review recent data and corresponding models to describe immune responses to V. cholerae infection and explain how the host microbiome may impact the pathogenesis of V. cholerae. In the ongoing battle against cholera, the intestinal microbiome represents a frontier for new approaches to intervention and prevention.
format	article
author	Ana A. Weil Rachel L. Becker Jason B. Harris
author_facet	Ana A. Weil Rachel L. Becker Jason B. Harris
author_sort	Ana A. Weil
title	<italic toggle="yes">Vibrio cholerae</italic> at the Intersection of Immunity and the Microbiome
title_short	<italic toggle="yes">Vibrio cholerae</italic> at the Intersection of Immunity and the Microbiome
title_full	<italic toggle="yes">Vibrio cholerae</italic> at the Intersection of Immunity and the Microbiome
title_fullStr	<italic toggle="yes">Vibrio cholerae</italic> at the Intersection of Immunity and the Microbiome
title_full_unstemmed	<italic toggle="yes">Vibrio cholerae</italic> at the Intersection of Immunity and the Microbiome
title_sort	<italic toggle="yes">vibrio cholerae</italic> at the intersection of immunity and the microbiome
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/c5a3f0360f2347e2aeddf5972924b098
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<italic toggle="yes">Vibrio cholerae</italic> at the Intersection of Immunity and the Microbiome

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