Association between Serum Lipid Parameters and Cognitive Performance in Older Adults

(1) Background: Previous studies have suggested the association between lipid profiles and cognitive function in older adults. However, they generated inconsistent results. We aim to determine the relationship between lipid profiles and cognitive performance in older adults. (2) Methods: We used the...

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Autores principales:	Jaeho Lee, Sohyae Lee, Jin-young Min, Kyoung-bok Min
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cognitive function lipid high-density lipoprotein cognitive performance aging Medicine R
Acceso en línea:	https://doaj.org/article/c5a4575e8fa14be5b4f2a2264a3f64bf
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spelling	oai:doaj.org-article:c5a4575e8fa14be5b4f2a2264a3f64bf2021-11-25T18:02:29ZAssociation between Serum Lipid Parameters and Cognitive Performance in Older Adults10.3390/jcm102254052077-0383https://doaj.org/article/c5a4575e8fa14be5b4f2a2264a3f64bf2021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5405https://doaj.org/toc/2077-0383(1) Background: Previous studies have suggested the association between lipid profiles and cognitive function in older adults. However, they generated inconsistent results. We aim to determine the relationship between lipid profiles and cognitive performance in older adults. (2) Methods: We used the 2011–2014 National Health and Nutrition Examination Survey. This study included 2215 participants who were aged more than 60 years old and free of coronary heart disease or stroke. Lipid profiles included total cholesterol (TC), low density lipid cholesterol (LDL), high density lipid cholesterol (HDL), and triglyceride (TG). Cognitive function was assessed using the digit symbol substitution test (DSST). (3) Results: Positive correlations of DSST were observed with TC (r = 0.111; <i>p</i> < 0.0001), HDL (r = 0.127; <i>p</i> < 0.0001), and LDL (r = 0.107; <i>p</i> = 0.0005). However, there was no significant relationship between TG and DSST. A one-unit increase in HDL was associated with an increase in DSST score (beta coefficient: 0.036; <i>p</i> = 0.018); but the association was not significant for LDL, TG, and TC. In the categorical analysis, the high HDL group had a higher DSST score than the low HDL group (beta = 3.113; <i>p</i> < 0.0001) and the low TG group was more likely to show a lower DSST score than the high TC group (beta = −1.837; <i>p</i> = 0.0461). However, LDL and TC showed no statistically significant associations. Moreover, HDL was only associated with a 0.701 times increased risk of cognitive impairment (95% CI = 0.523–0.938) in the logistic regression analysis. (4) Conclusions: Higher blood concentrations of HDL levels were positively associated with DSST scores in older adults. We suggest that the high levels of HDL may be a protective factor against cognitive impairment.Jaeho LeeSohyae LeeJin-young MinKyoung-bok MinMDPI AGarticlecognitive functionlipidhigh-density lipoproteincognitive performanceagingMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5405, p 5405 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cognitive function lipid high-density lipoprotein cognitive performance aging Medicine R
spellingShingle	cognitive function lipid high-density lipoprotein cognitive performance aging Medicine R Jaeho Lee Sohyae Lee Jin-young Min Kyoung-bok Min Association between Serum Lipid Parameters and Cognitive Performance in Older Adults
description	(1) Background: Previous studies have suggested the association between lipid profiles and cognitive function in older adults. However, they generated inconsistent results. We aim to determine the relationship between lipid profiles and cognitive performance in older adults. (2) Methods: We used the 2011–2014 National Health and Nutrition Examination Survey. This study included 2215 participants who were aged more than 60 years old and free of coronary heart disease or stroke. Lipid profiles included total cholesterol (TC), low density lipid cholesterol (LDL), high density lipid cholesterol (HDL), and triglyceride (TG). Cognitive function was assessed using the digit symbol substitution test (DSST). (3) Results: Positive correlations of DSST were observed with TC (r = 0.111; <i>p</i> < 0.0001), HDL (r = 0.127; <i>p</i> < 0.0001), and LDL (r = 0.107; <i>p</i> = 0.0005). However, there was no significant relationship between TG and DSST. A one-unit increase in HDL was associated with an increase in DSST score (beta coefficient: 0.036; <i>p</i> = 0.018); but the association was not significant for LDL, TG, and TC. In the categorical analysis, the high HDL group had a higher DSST score than the low HDL group (beta = 3.113; <i>p</i> < 0.0001) and the low TG group was more likely to show a lower DSST score than the high TC group (beta = −1.837; <i>p</i> = 0.0461). However, LDL and TC showed no statistically significant associations. Moreover, HDL was only associated with a 0.701 times increased risk of cognitive impairment (95% CI = 0.523–0.938) in the logistic regression analysis. (4) Conclusions: Higher blood concentrations of HDL levels were positively associated with DSST scores in older adults. We suggest that the high levels of HDL may be a protective factor against cognitive impairment.
format	article
author	Jaeho Lee Sohyae Lee Jin-young Min Kyoung-bok Min
author_facet	Jaeho Lee Sohyae Lee Jin-young Min Kyoung-bok Min
author_sort	Jaeho Lee
title	Association between Serum Lipid Parameters and Cognitive Performance in Older Adults
title_short	Association between Serum Lipid Parameters and Cognitive Performance in Older Adults
title_full	Association between Serum Lipid Parameters and Cognitive Performance in Older Adults
title_fullStr	Association between Serum Lipid Parameters and Cognitive Performance in Older Adults
title_full_unstemmed	Association between Serum Lipid Parameters and Cognitive Performance in Older Adults
title_sort	association between serum lipid parameters and cognitive performance in older adults
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c5a4575e8fa14be5b4f2a2264a3f64bf
work_keys_str_mv	AT jaeholee associationbetweenserumlipidparametersandcognitiveperformanceinolderadults AT sohyaelee associationbetweenserumlipidparametersandcognitiveperformanceinolderadults AT jinyoungmin associationbetweenserumlipidparametersandcognitiveperformanceinolderadults AT kyoungbokmin associationbetweenserumlipidparametersandcognitiveperformanceinolderadults
_version_	1718411706273628160

Association between Serum Lipid Parameters and Cognitive Performance in Older Adults

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