Prognostic value of MRI-measured tumor thickness in patients with tongue squamous cell carcinoma

Abstract This study aimed to assess the prognostic value of MRI-measured tumor thickness (MRI-TT) in patients with tongue squamous cell carcinoma (SCC). This single-center retrospective cohort study included 133 pathologically confirmed tongue SCC patients between January 2009 and October 2019. MRI...

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Autores principales:	Ki-Sun Park, Yangsean Choi, Jiwoong Kim, Kook-Jin Ahn, Bum-soo Kim, Youn Soo Lee, Dong-Il Sun, Min-Sik Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c5a5faceb03a48b0a8d7d7c215d00b0d
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spelling	oai:doaj.org-article:c5a5faceb03a48b0a8d7d7c215d00b0d2021-12-02T17:50:57ZPrognostic value of MRI-measured tumor thickness in patients with tongue squamous cell carcinoma10.1038/s41598-021-90655-z2045-2322https://doaj.org/article/c5a5faceb03a48b0a8d7d7c215d00b0d2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90655-zhttps://doaj.org/toc/2045-2322Abstract This study aimed to assess the prognostic value of MRI-measured tumor thickness (MRI-TT) in patients with tongue squamous cell carcinoma (SCC). This single-center retrospective cohort study included 133 pathologically confirmed tongue SCC patients between January 2009 and October 2019. MRI measurements of tongue SCC were based on axial and coronal T2-weighted (T2WI) and contrast-enhanced T1-weighted (CE-T1WI) images. Two radiologists independently measured MRI-TT. Intraclass correlation coefficients (ICC) were calculated for inter-rater agreements. Spearman’s rank correlation between MRI-TT and pathologic depth of invasion (pDOI) was assessed. Cox proportional hazards analyses on recurrence-free (RFS) and overall survival (OS) were performed for MRI-TT and pDOI. Kaplan–Meier survival curves were plotted with log-rank tests. The intra- and inter-rater agreements of MRI-TT were excellent (ICC: 0.829–0.897, all P < 0.001). The correlation between MRI-TT and pDOI was good (Spearman’s correlation coefficients: 0.72–0.76, P < 0.001). MRI-TT were significantly greater than pDOI in all axial and coronal T2WI and CE-T1WI (P < 0.001). In multivariate Cox proportional hazards analysis, MRI-TT measured on axial CE-T1WI yielded a significant prognostic value for OS (hazards ratio 2.77; P = 0.034). MRI-TT demonstrated excellent intra- and inter-rater agreements as well as high correlation with pDOI. MRI-TT may serve as a prognostic predictor in patients with tongue SCC.Ki-Sun ParkYangsean ChoiJiwoong KimKook-Jin AhnBum-soo KimYoun Soo LeeDong-Il SunMin-Sik KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ki-Sun Park Yangsean Choi Jiwoong Kim Kook-Jin Ahn Bum-soo Kim Youn Soo Lee Dong-Il Sun Min-Sik Kim Prognostic value of MRI-measured tumor thickness in patients with tongue squamous cell carcinoma
description	Abstract This study aimed to assess the prognostic value of MRI-measured tumor thickness (MRI-TT) in patients with tongue squamous cell carcinoma (SCC). This single-center retrospective cohort study included 133 pathologically confirmed tongue SCC patients between January 2009 and October 2019. MRI measurements of tongue SCC were based on axial and coronal T2-weighted (T2WI) and contrast-enhanced T1-weighted (CE-T1WI) images. Two radiologists independently measured MRI-TT. Intraclass correlation coefficients (ICC) were calculated for inter-rater agreements. Spearman’s rank correlation between MRI-TT and pathologic depth of invasion (pDOI) was assessed. Cox proportional hazards analyses on recurrence-free (RFS) and overall survival (OS) were performed for MRI-TT and pDOI. Kaplan–Meier survival curves were plotted with log-rank tests. The intra- and inter-rater agreements of MRI-TT were excellent (ICC: 0.829–0.897, all P < 0.001). The correlation between MRI-TT and pDOI was good (Spearman’s correlation coefficients: 0.72–0.76, P < 0.001). MRI-TT were significantly greater than pDOI in all axial and coronal T2WI and CE-T1WI (P < 0.001). In multivariate Cox proportional hazards analysis, MRI-TT measured on axial CE-T1WI yielded a significant prognostic value for OS (hazards ratio 2.77; P = 0.034). MRI-TT demonstrated excellent intra- and inter-rater agreements as well as high correlation with pDOI. MRI-TT may serve as a prognostic predictor in patients with tongue SCC.
format	article
author	Ki-Sun Park Yangsean Choi Jiwoong Kim Kook-Jin Ahn Bum-soo Kim Youn Soo Lee Dong-Il Sun Min-Sik Kim
author_facet	Ki-Sun Park Yangsean Choi Jiwoong Kim Kook-Jin Ahn Bum-soo Kim Youn Soo Lee Dong-Il Sun Min-Sik Kim
author_sort	Ki-Sun Park
title	Prognostic value of MRI-measured tumor thickness in patients with tongue squamous cell carcinoma
title_short	Prognostic value of MRI-measured tumor thickness in patients with tongue squamous cell carcinoma
title_full	Prognostic value of MRI-measured tumor thickness in patients with tongue squamous cell carcinoma
title_fullStr	Prognostic value of MRI-measured tumor thickness in patients with tongue squamous cell carcinoma
title_full_unstemmed	Prognostic value of MRI-measured tumor thickness in patients with tongue squamous cell carcinoma
title_sort	prognostic value of mri-measured tumor thickness in patients with tongue squamous cell carcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c5a5faceb03a48b0a8d7d7c215d00b0d
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Prognostic value of MRI-measured tumor thickness in patients with tongue squamous cell carcinoma

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