Ultra-high resolution optical coherence tomography for monitoring tear meniscus volume in dry eye after topical cyclosporine treatment

Jianhua Wang,1 Lele Cui,1 Meixiao Shen,1 Victor L Perez,1 Michael R Wang21Bascom Palmer Eye Institute, University of Miami Leonard M Miller School of Medicine, 2Electrical and Computer Engineering, University of Miami, Miami, FL, USAPurpose: This study was designed to determine the ability of ultra-...

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Autores principales:	Wang J, Cui L, Shen M, Perez VL, Wang MR
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/c5a667adf7ee44f6b3c287f6e5556565
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spelling	oai:doaj.org-article:c5a667adf7ee44f6b3c287f6e55565652021-12-02T06:17:23ZUltra-high resolution optical coherence tomography for monitoring tear meniscus volume in dry eye after topical cyclosporine treatment1177-54671177-5483https://doaj.org/article/c5a667adf7ee44f6b3c287f6e55565652012-06-01T00:00:00Zhttp://www.dovepress.com/ultra-high-resolution-optical-coherence-tomography-for-monitoring-tear-a10168https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Jianhua Wang,1 Lele Cui,1 Meixiao Shen,1 Victor L Perez,1 Michael R Wang21Bascom Palmer Eye Institute, University of Miami Leonard M Miller School of Medicine, 2Electrical and Computer Engineering, University of Miami, Miami, FL, USAPurpose: This study was designed to determine the ability of ultra-high-resolution optical coherence tomography (UHR-OCT) to monitor tear meniscus volume after dry eye treatment with Restasis&reg; (0.05% cyclosporine).Methods: UHR-OCT was used to image the upper and lower tear menisci (height and volume) in 14 consecutive dry eye patients at baseline. The treatment group was initiated on daily Restasis and measurements were repeated at 1 and 2 months while on treatment. All measurements were performed immediately after a blink.Results: The baseline tear meniscus volumes were 0.40 &plusmn; 0.19 &micro;L (upper) and 0.43 &plusmn; 0.18 &micro;L (lower). In the treatment group, tear meniscus heights showed significant increases of both upper (post-hoc test with Bonferroni correction: P = 0.003) and lower (P = 0.0003) tear menisci, after 1 month on Restasis. The tear meniscus volumes in the treatment group after 1 month of Restasis showed significant increases of both upper (P = 0.007) and lower (P = 0.007) tear menisci. At 2 months, the increase of the tear meniscus was still evident in all measured variables compared with baseline (P &lt; 0.05).Conclusion: UHR-OCT offers a promising tool for monitoring dry eye treatment. With this method, a measurable increase in tear meniscus volume was evident after 1 month of treatment with Restasis in dry eye patients.Keywords: tear menisci, UHR-OCT, tear dynamics, dry eye, Restasis&reg;Wang JCui LShen MPerez VLWang MRDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2012, Iss default, Pp 933-938 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Wang J Cui L Shen M Perez VL Wang MR Ultra-high resolution optical coherence tomography for monitoring tear meniscus volume in dry eye after topical cyclosporine treatment
description	Jianhua Wang,1 Lele Cui,1 Meixiao Shen,1 Victor L Perez,1 Michael R Wang21Bascom Palmer Eye Institute, University of Miami Leonard M Miller School of Medicine, 2Electrical and Computer Engineering, University of Miami, Miami, FL, USAPurpose: This study was designed to determine the ability of ultra-high-resolution optical coherence tomography (UHR-OCT) to monitor tear meniscus volume after dry eye treatment with Restasis&reg; (0.05% cyclosporine).Methods: UHR-OCT was used to image the upper and lower tear menisci (height and volume) in 14 consecutive dry eye patients at baseline. The treatment group was initiated on daily Restasis and measurements were repeated at 1 and 2 months while on treatment. All measurements were performed immediately after a blink.Results: The baseline tear meniscus volumes were 0.40 &plusmn; 0.19 &micro;L (upper) and 0.43 &plusmn; 0.18 &micro;L (lower). In the treatment group, tear meniscus heights showed significant increases of both upper (post-hoc test with Bonferroni correction: P = 0.003) and lower (P = 0.0003) tear menisci, after 1 month on Restasis. The tear meniscus volumes in the treatment group after 1 month of Restasis showed significant increases of both upper (P = 0.007) and lower (P = 0.007) tear menisci. At 2 months, the increase of the tear meniscus was still evident in all measured variables compared with baseline (P &lt; 0.05).Conclusion: UHR-OCT offers a promising tool for monitoring dry eye treatment. With this method, a measurable increase in tear meniscus volume was evident after 1 month of treatment with Restasis in dry eye patients.Keywords: tear menisci, UHR-OCT, tear dynamics, dry eye, Restasis&reg;
format	article
author	Wang J Cui L Shen M Perez VL Wang MR
author_facet	Wang J Cui L Shen M Perez VL Wang MR
author_sort	Wang J
title	Ultra-high resolution optical coherence tomography for monitoring tear meniscus volume in dry eye after topical cyclosporine treatment
title_short	Ultra-high resolution optical coherence tomography for monitoring tear meniscus volume in dry eye after topical cyclosporine treatment
title_full	Ultra-high resolution optical coherence tomography for monitoring tear meniscus volume in dry eye after topical cyclosporine treatment
title_fullStr	Ultra-high resolution optical coherence tomography for monitoring tear meniscus volume in dry eye after topical cyclosporine treatment
title_full_unstemmed	Ultra-high resolution optical coherence tomography for monitoring tear meniscus volume in dry eye after topical cyclosporine treatment
title_sort	ultra-high resolution optical coherence tomography for monitoring tear meniscus volume in dry eye after topical cyclosporine treatment
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/c5a667adf7ee44f6b3c287f6e5556565
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Ultra-high resolution optical coherence tomography for monitoring tear meniscus volume in dry eye after topical cyclosporine treatment

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