Structural and Functional Abnormalities in Knee Osteoarthritis Pain Revealed With Multimodal Magnetic Resonance Imaging

The knee osteoarthritis (KOA) pain is the most common form of arthritis pain affecting millions of people worldwide. Long-term KOA pain causes motor impairment and affects affective and cognitive functions. However, little is known about the structural and functional abnormalities induced by long-te...

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Autores principales:	Hua Guo, Yuqing Wang, Lihua Qiu, Xiaoqi Huang, Chengqi He, Junran Zhang, Qiyong Gong
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	knee osteoarthritis pain structural MRI resting-state fMRI GMV ALFF Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/c5a6f8aeb40d4187b45d3d8406dfbc58
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spelling	oai:doaj.org-article:c5a6f8aeb40d4187b45d3d8406dfbc582021-12-01T13:21:39ZStructural and Functional Abnormalities in Knee Osteoarthritis Pain Revealed With Multimodal Magnetic Resonance Imaging1662-516110.3389/fnhum.2021.783355https://doaj.org/article/c5a6f8aeb40d4187b45d3d8406dfbc582021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnhum.2021.783355/fullhttps://doaj.org/toc/1662-5161The knee osteoarthritis (KOA) pain is the most common form of arthritis pain affecting millions of people worldwide. Long-term KOA pain causes motor impairment and affects affective and cognitive functions. However, little is known about the structural and functional abnormalities induced by long-term KOA pain. In this work, high-resolution structural magnetic resonance imaging (sMRI) and resting-state functional MRI (rs-fMRI) data were acquired in patients with KOA and age-, sex-matched healthy controls (HC). Gray matter volume (GMV) and fractional amplitude of low-frequency fluctuation (fALFF) were used to study the structural and functional abnormalities in patients with KOA. Compared with HC, patients with KOA showed reduced GMV in bilateral insula and bilateral hippocampus, and reduced fALFF in left cerebellum, precentral gyrus, and the right superior occipital gyrus. Patients with KOA also showed increased fALFF in left insula and bilateral hippocampus. In addition, the abnormal GMV in left insula and fALFF in left fusiform were closely correlated with the pain severity or disease duration. These results indicated that long KOA pain leads to brain structural and functional impairments in motor, visual, cognitive, and affective functions that related to brain areas. Our findings may facilitate to understand the neural basis of KOA pain and the future therapy to relieve disease symptoms.Hua GuoYuqing WangLihua QiuXiaoqi HuangChengqi HeJunran ZhangQiyong GongFrontiers Media S.A.articleknee osteoarthritis painstructural MRIresting-state fMRIGMVALFFNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Human Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	knee osteoarthritis pain structural MRI resting-state fMRI GMV ALFF Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	knee osteoarthritis pain structural MRI resting-state fMRI GMV ALFF Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Hua Guo Yuqing Wang Lihua Qiu Xiaoqi Huang Chengqi He Junran Zhang Qiyong Gong Structural and Functional Abnormalities in Knee Osteoarthritis Pain Revealed With Multimodal Magnetic Resonance Imaging
description	The knee osteoarthritis (KOA) pain is the most common form of arthritis pain affecting millions of people worldwide. Long-term KOA pain causes motor impairment and affects affective and cognitive functions. However, little is known about the structural and functional abnormalities induced by long-term KOA pain. In this work, high-resolution structural magnetic resonance imaging (sMRI) and resting-state functional MRI (rs-fMRI) data were acquired in patients with KOA and age-, sex-matched healthy controls (HC). Gray matter volume (GMV) and fractional amplitude of low-frequency fluctuation (fALFF) were used to study the structural and functional abnormalities in patients with KOA. Compared with HC, patients with KOA showed reduced GMV in bilateral insula and bilateral hippocampus, and reduced fALFF in left cerebellum, precentral gyrus, and the right superior occipital gyrus. Patients with KOA also showed increased fALFF in left insula and bilateral hippocampus. In addition, the abnormal GMV in left insula and fALFF in left fusiform were closely correlated with the pain severity or disease duration. These results indicated that long KOA pain leads to brain structural and functional impairments in motor, visual, cognitive, and affective functions that related to brain areas. Our findings may facilitate to understand the neural basis of KOA pain and the future therapy to relieve disease symptoms.
format	article
author	Hua Guo Yuqing Wang Lihua Qiu Xiaoqi Huang Chengqi He Junran Zhang Qiyong Gong
author_facet	Hua Guo Yuqing Wang Lihua Qiu Xiaoqi Huang Chengqi He Junran Zhang Qiyong Gong
author_sort	Hua Guo
title	Structural and Functional Abnormalities in Knee Osteoarthritis Pain Revealed With Multimodal Magnetic Resonance Imaging
title_short	Structural and Functional Abnormalities in Knee Osteoarthritis Pain Revealed With Multimodal Magnetic Resonance Imaging
title_full	Structural and Functional Abnormalities in Knee Osteoarthritis Pain Revealed With Multimodal Magnetic Resonance Imaging
title_fullStr	Structural and Functional Abnormalities in Knee Osteoarthritis Pain Revealed With Multimodal Magnetic Resonance Imaging
title_full_unstemmed	Structural and Functional Abnormalities in Knee Osteoarthritis Pain Revealed With Multimodal Magnetic Resonance Imaging
title_sort	structural and functional abnormalities in knee osteoarthritis pain revealed with multimodal magnetic resonance imaging
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c5a6f8aeb40d4187b45d3d8406dfbc58
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_version_	1718405137716740096

Structural and Functional Abnormalities in Knee Osteoarthritis Pain Revealed With Multimodal Magnetic Resonance Imaging

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