A BMPR2/YY1 Signaling Axis Is Required for Human Cytomegalovirus Latency in Undifferentiated Myeloid Cells

Understanding the mechanisms which regulate HCMV latency could allow therapeutic targeting of the latent virus reservoir from where virus reactivation can cause severe disease. We show that the BMPR2/TGFbeta receptor/YY1 signaling axis is crucial to maintain HCMV latency in undifferentiated cells a...

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Autores principales:	Emma Poole, Maria Cristina Carlan da Silva, Chris Huang, Marianne Perera, Sarah Jackson, Ian J. Groves, Mark Wills, Amer Rana, John Sinclair
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/c5a89e14f27243eba150c45f5244720d
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spelling	oai:doaj.org-article:c5a89e14f27243eba150c45f5244720d2021-11-03T21:15:02ZA BMPR2/YY1 Signaling Axis Is Required for Human Cytomegalovirus Latency in Undifferentiated Myeloid Cells2150-751110.1128/mBio.00227-21https://doaj.org/article/c5a89e14f27243eba150c45f5244720d2021-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00227-21https://doaj.org/toc/2150-7511 Understanding the mechanisms which regulate HCMV latency could allow therapeutic targeting of the latent virus reservoir from where virus reactivation can cause severe disease. We show that the BMPR2/TGFbeta receptor/YY1 signaling axis is crucial to maintain HCMV latency in undifferentiated cells and that pharmacological reduction of BMPR2 in latently infected cells leads to reactivation of the viral lytic transcription program, which renders the infected cell open to immune detection and clearance in infected individuals.Emma PooleMaria Cristina Carlan da SilvaChris HuangMarianne PereraSarah JacksonIan J. GrovesMark WillsAmer RanaJohn SinclairAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 3 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Emma Poole Maria Cristina Carlan da Silva Chris Huang Marianne Perera Sarah Jackson Ian J. Groves Mark Wills Amer Rana John Sinclair A BMPR2/YY1 Signaling Axis Is Required for Human Cytomegalovirus Latency in Undifferentiated Myeloid Cells
description	Understanding the mechanisms which regulate HCMV latency could allow therapeutic targeting of the latent virus reservoir from where virus reactivation can cause severe disease. We show that the BMPR2/TGFbeta receptor/YY1 signaling axis is crucial to maintain HCMV latency in undifferentiated cells and that pharmacological reduction of BMPR2 in latently infected cells leads to reactivation of the viral lytic transcription program, which renders the infected cell open to immune detection and clearance in infected individuals.
format	article
author	Emma Poole Maria Cristina Carlan da Silva Chris Huang Marianne Perera Sarah Jackson Ian J. Groves Mark Wills Amer Rana John Sinclair
author_facet	Emma Poole Maria Cristina Carlan da Silva Chris Huang Marianne Perera Sarah Jackson Ian J. Groves Mark Wills Amer Rana John Sinclair
author_sort	Emma Poole
title	A BMPR2/YY1 Signaling Axis Is Required for Human Cytomegalovirus Latency in Undifferentiated Myeloid Cells
title_short	A BMPR2/YY1 Signaling Axis Is Required for Human Cytomegalovirus Latency in Undifferentiated Myeloid Cells
title_full	A BMPR2/YY1 Signaling Axis Is Required for Human Cytomegalovirus Latency in Undifferentiated Myeloid Cells
title_fullStr	A BMPR2/YY1 Signaling Axis Is Required for Human Cytomegalovirus Latency in Undifferentiated Myeloid Cells
title_full_unstemmed	A BMPR2/YY1 Signaling Axis Is Required for Human Cytomegalovirus Latency in Undifferentiated Myeloid Cells
title_sort	bmpr2/yy1 signaling axis is required for human cytomegalovirus latency in undifferentiated myeloid cells
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/c5a89e14f27243eba150c45f5244720d
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A BMPR2/YY1 Signaling Axis Is Required for Human Cytomegalovirus Latency in Undifferentiated Myeloid Cells

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