The Contribution of Dietary Fructose to Non-alcoholic Fatty Liver Disease

Fructose, especially industrial fructose (sucrose and high fructose corn syrup) is commonly used in all kinds of beverages and processed foods. Liver is the primary organ for fructose metabolism, recent studies suggest that excessive fructose intake is a driving force in non-alcoholic fatty liver di...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Siyu Yu, Chunlin Li, Guang Ji, Li Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	non-alcoholic fatty liver disease (NAFLD) fructose intestinal environment de novo lipogenesis inflammation Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/c5add71ffb0a4a7a84fe58ab1ebd8734
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c5add71ffb0a4a7a84fe58ab1ebd8734
record_format	dspace
spelling	oai:doaj.org-article:c5add71ffb0a4a7a84fe58ab1ebd87342021-11-18T09:52:26ZThe Contribution of Dietary Fructose to Non-alcoholic Fatty Liver Disease1663-981210.3389/fphar.2021.783393https://doaj.org/article/c5add71ffb0a4a7a84fe58ab1ebd87342021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.783393/fullhttps://doaj.org/toc/1663-9812Fructose, especially industrial fructose (sucrose and high fructose corn syrup) is commonly used in all kinds of beverages and processed foods. Liver is the primary organ for fructose metabolism, recent studies suggest that excessive fructose intake is a driving force in non-alcoholic fatty liver disease (NAFLD). Dietary fructose metabolism begins at the intestine, along with its metabolites, may influence gut barrier and microbiota community, and contribute to increased nutrient absorption and lipogenic substrates overflow to the liver. Overwhelming fructose and the gut microbiota-derived fructose metabolites (e.g., acetate, butyric acid, butyrate and propionate) trigger the de novo lipogenesis in the liver, and result in lipid accumulation and hepatic steatosis. Fructose also reprograms the metabolic phenotype of liver cells (hepatocytes, macrophages, NK cells, etc.), and induces the occurrence of inflammation in the liver. Besides, there is endogenous fructose production that expands the fructose pool. Considering the close association of fructose metabolism and NAFLD, the drug development that focuses on blocking the absorption and metabolism of fructose might be promising strategies for NAFLD. Here we provide a systematic discussion of the underlying mechanisms of dietary fructose in contributing to the development and progression of NAFLD, and suggest the possible targets to prevent the pathogenetic process.Siyu YuChunlin LiGuang JiLi ZhangFrontiers Media S.A.articlenon-alcoholic fatty liver disease (NAFLD)fructoseintestinal environmentde novo lipogenesisinflammationTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	non-alcoholic fatty liver disease (NAFLD) fructose intestinal environment de novo lipogenesis inflammation Therapeutics. Pharmacology RM1-950
spellingShingle	non-alcoholic fatty liver disease (NAFLD) fructose intestinal environment de novo lipogenesis inflammation Therapeutics. Pharmacology RM1-950 Siyu Yu Chunlin Li Guang Ji Li Zhang The Contribution of Dietary Fructose to Non-alcoholic Fatty Liver Disease
description	Fructose, especially industrial fructose (sucrose and high fructose corn syrup) is commonly used in all kinds of beverages and processed foods. Liver is the primary organ for fructose metabolism, recent studies suggest that excessive fructose intake is a driving force in non-alcoholic fatty liver disease (NAFLD). Dietary fructose metabolism begins at the intestine, along with its metabolites, may influence gut barrier and microbiota community, and contribute to increased nutrient absorption and lipogenic substrates overflow to the liver. Overwhelming fructose and the gut microbiota-derived fructose metabolites (e.g., acetate, butyric acid, butyrate and propionate) trigger the de novo lipogenesis in the liver, and result in lipid accumulation and hepatic steatosis. Fructose also reprograms the metabolic phenotype of liver cells (hepatocytes, macrophages, NK cells, etc.), and induces the occurrence of inflammation in the liver. Besides, there is endogenous fructose production that expands the fructose pool. Considering the close association of fructose metabolism and NAFLD, the drug development that focuses on blocking the absorption and metabolism of fructose might be promising strategies for NAFLD. Here we provide a systematic discussion of the underlying mechanisms of dietary fructose in contributing to the development and progression of NAFLD, and suggest the possible targets to prevent the pathogenetic process.
format	article
author	Siyu Yu Chunlin Li Guang Ji Li Zhang
author_facet	Siyu Yu Chunlin Li Guang Ji Li Zhang
author_sort	Siyu Yu
title	The Contribution of Dietary Fructose to Non-alcoholic Fatty Liver Disease
title_short	The Contribution of Dietary Fructose to Non-alcoholic Fatty Liver Disease
title_full	The Contribution of Dietary Fructose to Non-alcoholic Fatty Liver Disease
title_fullStr	The Contribution of Dietary Fructose to Non-alcoholic Fatty Liver Disease
title_full_unstemmed	The Contribution of Dietary Fructose to Non-alcoholic Fatty Liver Disease
title_sort	contribution of dietary fructose to non-alcoholic fatty liver disease
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c5add71ffb0a4a7a84fe58ab1ebd8734
work_keys_str_mv	AT siyuyu thecontributionofdietaryfructosetononalcoholicfattyliverdisease AT chunlinli thecontributionofdietaryfructosetononalcoholicfattyliverdisease AT guangji thecontributionofdietaryfructosetononalcoholicfattyliverdisease AT lizhang thecontributionofdietaryfructosetononalcoholicfattyliverdisease AT siyuyu contributionofdietaryfructosetononalcoholicfattyliverdisease AT chunlinli contributionofdietaryfructosetononalcoholicfattyliverdisease AT guangji contributionofdietaryfructosetononalcoholicfattyliverdisease AT lizhang contributionofdietaryfructosetononalcoholicfattyliverdisease
_version_	1718420870347620352

The Contribution of Dietary Fructose to Non-alcoholic Fatty Liver Disease

Ejemplares similares