Binding of the von Willebrand Factor A Domain of Capillary Morphogenesis Protein 2 to Anthrax Protective Antigen Vaccine Reduces Immunogenicity in Mice

Binding of the von Willebrand Factor A Domain of Capillary Morphogenesis Protein 2 to Anthrax Protective Antigen Vaccine Reduces Immunogenicity in Mice

ABSTRACT Protective antigen (PA) is a component of anthrax toxin that can elicit toxin-neutralizing antibody responses. PA is also the major antigen in the current vaccine to prevent anthrax, but stability problems with recombinant proteins have complicated the development of new vaccines containing...

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Bibliographic Details
Main Authors: Fabiana Freire Mendes de Oliveira, Sireesha Mamillapalli, Srinivas Gonti, Robert N. Brey, Han Li, Jarad Schiffer, Arturo Casadevall, James G. Bann
Format: article
Language:EN
Published: American Society for Microbiology 2020
Subjects:
anthrax
antigen processing
immunization
protein stability
Microbiology
QR1-502
Online Access:https://doaj.org/article/c5b08a3442284ba9b28cd6995fad9269
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