Effects of vitamin D supplementation on cognitive and emotional functioning in young adults--a randomised controlled trial.

<h4>Background</h4>Epidemiological research links vitamin D status to various brain-related outcomes. However, few trials examine whether supplementation can improve such outcomes and none have examined effects on cognition. This study examined whether Vitamin D supplementation led to im...

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Autores principales:	Angela J Dean, Mark A Bellgrove, Teresa Hall, Wei Ming Jonathan Phan, Darryl W Eyles, David Kvaskoff, John J McGrath
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c5b25e0cb6544d07b88f12a019837ab5
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spelling	oai:doaj.org-article:c5b25e0cb6544d07b88f12a019837ab52021-11-18T07:34:59ZEffects of vitamin D supplementation on cognitive and emotional functioning in young adults--a randomised controlled trial.1932-620310.1371/journal.pone.0025966https://doaj.org/article/c5b25e0cb6544d07b88f12a019837ab52011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22073146/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Epidemiological research links vitamin D status to various brain-related outcomes. However, few trials examine whether supplementation can improve such outcomes and none have examined effects on cognition. This study examined whether Vitamin D supplementation led to improvements in diverse measures of cognitive and emotional functioning, and hypothesised that supplementation would lead to improvements in these outcomes compared to placebo.<h4>Methods/principal findings</h4>Healthy young adults were recruited to a parallel-arm, double-blind trial conducted at The University of Queensland. Participants were randomly allocated to receive Vitamin D (one capsule daily, containing 5000 IU cholecalciferol) or identical placebo capsule for six weeks. All participants and outcome assessors were blinded to group assignment. Primary outcome measures assessed at baseline and 6 weeks were working memory, response inhibition and cognitive flexibility. Secondary outcomes were: hallucination-proneness, psychotic-like experiences, and ratings of depression, anxiety and anger. 128 participants were recruited, randomised and included in primary analyses (vitamin D n = 63; placebo n = 65). Despite significant increases in vitamin D status in the active group, no significant changes were observed in working memory (F = 1.09; p = 0.30), response inhibition (F = 0.82; p = 0.37), cognitive flexibility (F = 1.37; p = 0.24) or secondary outcomes. No serious adverse effects were reported.<h4>Conclusions</h4>Our findings indicate that vitamin D supplementation does not influence cognitive or emotional functioning in healthy young adults. Future controlled trials in targeted populations of interest are required to determine whether supplementation can improve functioning in these domains. Australian and New Zealand Clinical Trials Registry; ACTRN12610000318088.Angela J DeanMark A BellgroveTeresa HallWei Ming Jonathan PhanDarryl W EylesDavid KvaskoffJohn J McGrathPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 11, p e25966 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Angela J Dean Mark A Bellgrove Teresa Hall Wei Ming Jonathan Phan Darryl W Eyles David Kvaskoff John J McGrath Effects of vitamin D supplementation on cognitive and emotional functioning in young adults--a randomised controlled trial.
description	<h4>Background</h4>Epidemiological research links vitamin D status to various brain-related outcomes. However, few trials examine whether supplementation can improve such outcomes and none have examined effects on cognition. This study examined whether Vitamin D supplementation led to improvements in diverse measures of cognitive and emotional functioning, and hypothesised that supplementation would lead to improvements in these outcomes compared to placebo.<h4>Methods/principal findings</h4>Healthy young adults were recruited to a parallel-arm, double-blind trial conducted at The University of Queensland. Participants were randomly allocated to receive Vitamin D (one capsule daily, containing 5000 IU cholecalciferol) or identical placebo capsule for six weeks. All participants and outcome assessors were blinded to group assignment. Primary outcome measures assessed at baseline and 6 weeks were working memory, response inhibition and cognitive flexibility. Secondary outcomes were: hallucination-proneness, psychotic-like experiences, and ratings of depression, anxiety and anger. 128 participants were recruited, randomised and included in primary analyses (vitamin D n = 63; placebo n = 65). Despite significant increases in vitamin D status in the active group, no significant changes were observed in working memory (F = 1.09; p = 0.30), response inhibition (F = 0.82; p = 0.37), cognitive flexibility (F = 1.37; p = 0.24) or secondary outcomes. No serious adverse effects were reported.<h4>Conclusions</h4>Our findings indicate that vitamin D supplementation does not influence cognitive or emotional functioning in healthy young adults. Future controlled trials in targeted populations of interest are required to determine whether supplementation can improve functioning in these domains. Australian and New Zealand Clinical Trials Registry; ACTRN12610000318088.
format	article
author	Angela J Dean Mark A Bellgrove Teresa Hall Wei Ming Jonathan Phan Darryl W Eyles David Kvaskoff John J McGrath
author_facet	Angela J Dean Mark A Bellgrove Teresa Hall Wei Ming Jonathan Phan Darryl W Eyles David Kvaskoff John J McGrath
author_sort	Angela J Dean
title	Effects of vitamin D supplementation on cognitive and emotional functioning in young adults--a randomised controlled trial.
title_short	Effects of vitamin D supplementation on cognitive and emotional functioning in young adults--a randomised controlled trial.
title_full	Effects of vitamin D supplementation on cognitive and emotional functioning in young adults--a randomised controlled trial.
title_fullStr	Effects of vitamin D supplementation on cognitive and emotional functioning in young adults--a randomised controlled trial.
title_full_unstemmed	Effects of vitamin D supplementation on cognitive and emotional functioning in young adults--a randomised controlled trial.
title_sort	effects of vitamin d supplementation on cognitive and emotional functioning in young adults--a randomised controlled trial.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/c5b25e0cb6544d07b88f12a019837ab5
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Effects of vitamin D supplementation on cognitive and emotional functioning in young adults--a randomised controlled trial.

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