Recurrent Strongyloides stercoralis infection in an HIV+ patient

Although infection with Strongyloides stercoralis is often subclinical, some infections persist for decades due to the parasite’s autoinfective lifecycle. Hyperinfection syndrome, however, characterized by a massive increase in parasite burden as a result of host immunosuppression causes a myriad of...

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Autores principales: Kelli Bagwell, Jaya Vasudevan, Kristin Mondy
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
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HIV
Acceso en línea:https://doaj.org/article/c5b85c9114984ffa95bbf42536f12b39
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spelling oai:doaj.org-article:c5b85c9114984ffa95bbf42536f12b392021-11-04T04:31:08ZRecurrent Strongyloides stercoralis infection in an HIV+ patient2214-250910.1016/j.idcr.2021.e01325https://doaj.org/article/c5b85c9114984ffa95bbf42536f12b392021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S221425092100281Xhttps://doaj.org/toc/2214-2509Although infection with Strongyloides stercoralis is often subclinical, some infections persist for decades due to the parasite’s autoinfective lifecycle. Hyperinfection syndrome, however, characterized by a massive increase in parasite burden as a result of host immunosuppression causes a myriad of clinical symptoms and is associated with high mortality. Use of corticosteroids and infection with HTLV-1 virus are the biggest traditional risk factors for hyperinfection syndrome, though its development can occur with virtually any degree of immunosuppression. Recurrent hyperinfection syndrome, though rare, has also been demonstrated in persons with ongoing immunosuppression, prompting many experts to recommend continued prophylactic treatment in at risk populations. We present the case of a recurrent S. stercoralis hyperinfection occurring four years after previous treatment with anti-helminthic therapy in a patient with AIDS with intermittent adherence to antiretroviral therapy (ART), highlighting diagnostic and treatment issues in the management of recurrent S. stercoralis infection.Kelli BagwellJaya VasudevanKristin MondyElsevierarticleHIVAIDSRecurrent Strongyloides stercoralis hyperinfectionInfectious and parasitic diseasesRC109-216ENIDCases, Vol 26, Iss , Pp e01325- (2021)
institution DOAJ
collection DOAJ
language EN
topic HIV
AIDS
Recurrent Strongyloides stercoralis hyperinfection
Infectious and parasitic diseases
RC109-216
spellingShingle HIV
AIDS
Recurrent Strongyloides stercoralis hyperinfection
Infectious and parasitic diseases
RC109-216
Kelli Bagwell
Jaya Vasudevan
Kristin Mondy
Recurrent Strongyloides stercoralis infection in an HIV+ patient
description Although infection with Strongyloides stercoralis is often subclinical, some infections persist for decades due to the parasite’s autoinfective lifecycle. Hyperinfection syndrome, however, characterized by a massive increase in parasite burden as a result of host immunosuppression causes a myriad of clinical symptoms and is associated with high mortality. Use of corticosteroids and infection with HTLV-1 virus are the biggest traditional risk factors for hyperinfection syndrome, though its development can occur with virtually any degree of immunosuppression. Recurrent hyperinfection syndrome, though rare, has also been demonstrated in persons with ongoing immunosuppression, prompting many experts to recommend continued prophylactic treatment in at risk populations. We present the case of a recurrent S. stercoralis hyperinfection occurring four years after previous treatment with anti-helminthic therapy in a patient with AIDS with intermittent adherence to antiretroviral therapy (ART), highlighting diagnostic and treatment issues in the management of recurrent S. stercoralis infection.
format article
author Kelli Bagwell
Jaya Vasudevan
Kristin Mondy
author_facet Kelli Bagwell
Jaya Vasudevan
Kristin Mondy
author_sort Kelli Bagwell
title Recurrent Strongyloides stercoralis infection in an HIV+ patient
title_short Recurrent Strongyloides stercoralis infection in an HIV+ patient
title_full Recurrent Strongyloides stercoralis infection in an HIV+ patient
title_fullStr Recurrent Strongyloides stercoralis infection in an HIV+ patient
title_full_unstemmed Recurrent Strongyloides stercoralis infection in an HIV+ patient
title_sort recurrent strongyloides stercoralis infection in an hiv+ patient
publisher Elsevier
publishDate 2021
url https://doaj.org/article/c5b85c9114984ffa95bbf42536f12b39
work_keys_str_mv AT kellibagwell recurrentstrongyloidesstercoralisinfectioninanhivpatient
AT jayavasudevan recurrentstrongyloidesstercoralisinfectioninanhivpatient
AT kristinmondy recurrentstrongyloidesstercoralisinfectioninanhivpatient
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