Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma

MYCN amplification is common in neuroblastomas. Here the authors analyse the MYCN amplicon structure and its epigenetic regulation by integrating short- and longread genomic and epigenomic data and find two classes of MYCN amplicons in neuroblastomas, one driven by local enhancers and the other by h...

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Autores principales:	Konstantin Helmsauer, Maria E. Valieva, Salaheddine Ali, Rocío Chamorro González, Robert Schöpflin, Claudia Röefzaad, Yi Bei, Heathcliff Dorado Garcia, Elias Rodriguez-Fos, Montserrat Puiggròs, Katharina Kasack, Kerstin Haase, Csilla Keskeny, Celine Y. Chen, Luis P. Kuschel, Philipp Euskirchen, Verena Heinrich, Michael I. Robson, Carolina Rosswog, Joern Toedling, Annabell Szymansky, Falk Hertwig, Matthias Fischer, David Torrents, Angelika Eggert, Johannes H. Schulte, Stefan Mundlos, Anton G. Henssen, Richard P. Koche
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c5b9fcaacd9648e4831d4de98b3e2479
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spelling	oai:doaj.org-article:c5b9fcaacd9648e4831d4de98b3e24792021-12-02T16:56:51ZEnhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma10.1038/s41467-020-19452-y2041-1723https://doaj.org/article/c5b9fcaacd9648e4831d4de98b3e24792020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19452-yhttps://doaj.org/toc/2041-1723MYCN amplification is common in neuroblastomas. Here the authors analyse the MYCN amplicon structure and its epigenetic regulation by integrating short- and longread genomic and epigenomic data and find two classes of MYCN amplicons in neuroblastomas, one driven by local enhancers and the other by hijacking of distal regulatory elements.Konstantin HelmsauerMaria E. ValievaSalaheddine AliRocío Chamorro GonzálezRobert SchöpflinClaudia RöefzaadYi BeiHeathcliff Dorado GarciaElias Rodriguez-FosMontserrat PuiggròsKatharina KasackKerstin HaaseCsilla KeskenyCeline Y. ChenLuis P. KuschelPhilipp EuskirchenVerena HeinrichMichael I. RobsonCarolina RosswogJoern ToedlingAnnabell SzymanskyFalk HertwigMatthias FischerDavid TorrentsAngelika EggertJohannes H. SchulteStefan MundlosAnton G. HenssenRichard P. KocheNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Konstantin Helmsauer Maria E. Valieva Salaheddine Ali Rocío Chamorro González Robert Schöpflin Claudia Röefzaad Yi Bei Heathcliff Dorado Garcia Elias Rodriguez-Fos Montserrat Puiggròs Katharina Kasack Kerstin Haase Csilla Keskeny Celine Y. Chen Luis P. Kuschel Philipp Euskirchen Verena Heinrich Michael I. Robson Carolina Rosswog Joern Toedling Annabell Szymansky Falk Hertwig Matthias Fischer David Torrents Angelika Eggert Johannes H. Schulte Stefan Mundlos Anton G. Henssen Richard P. Koche Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma
description	MYCN amplification is common in neuroblastomas. Here the authors analyse the MYCN amplicon structure and its epigenetic regulation by integrating short- and longread genomic and epigenomic data and find two classes of MYCN amplicons in neuroblastomas, one driven by local enhancers and the other by hijacking of distal regulatory elements.
format	article
author	Konstantin Helmsauer Maria E. Valieva Salaheddine Ali Rocío Chamorro González Robert Schöpflin Claudia Röefzaad Yi Bei Heathcliff Dorado Garcia Elias Rodriguez-Fos Montserrat Puiggròs Katharina Kasack Kerstin Haase Csilla Keskeny Celine Y. Chen Luis P. Kuschel Philipp Euskirchen Verena Heinrich Michael I. Robson Carolina Rosswog Joern Toedling Annabell Szymansky Falk Hertwig Matthias Fischer David Torrents Angelika Eggert Johannes H. Schulte Stefan Mundlos Anton G. Henssen Richard P. Koche
author_facet	Konstantin Helmsauer Maria E. Valieva Salaheddine Ali Rocío Chamorro González Robert Schöpflin Claudia Röefzaad Yi Bei Heathcliff Dorado Garcia Elias Rodriguez-Fos Montserrat Puiggròs Katharina Kasack Kerstin Haase Csilla Keskeny Celine Y. Chen Luis P. Kuschel Philipp Euskirchen Verena Heinrich Michael I. Robson Carolina Rosswog Joern Toedling Annabell Szymansky Falk Hertwig Matthias Fischer David Torrents Angelika Eggert Johannes H. Schulte Stefan Mundlos Anton G. Henssen Richard P. Koche
author_sort	Konstantin Helmsauer
title	Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma
title_short	Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma
title_full	Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma
title_fullStr	Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma
title_full_unstemmed	Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma
title_sort	enhancer hijacking determines extrachromosomal circular mycn amplicon architecture in neuroblastoma
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c5b9fcaacd9648e4831d4de98b3e2479
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Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma

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