Relationship between Changes in Hematological Parameters, Levels of Acute Phase Proteins and Redox Homeostasis during Acute Babesia canis Infection in Dogs

Hemolysis and systemic acute inflammation characterize canine babesiosis caused by the intraerythrocytic protozoan parasite Babesia canis. Our hypothesis was that blood redox homeostasis of patients that suffered acute B. canis infection might be disturbed even after treatment with imidocarb-dipropi...

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Autores principales:	Spariosu Kristina, Janjić Filip, Andrić Jelena Francuski, Radaković Milena, Beletić Anđelo, Filipović Milica Kovačević, Milanović Svetlana
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2021
Materias:	acute phase proteins babesiosis erythrocytes inflammation oxidative stress Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/c5ba7a32cb2349c982666253249ef7a6
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spelling	oai:doaj.org-article:c5ba7a32cb2349c982666253249ef7a62021-11-17T21:27:54ZRelationship between Changes in Hematological Parameters, Levels of Acute Phase Proteins and Redox Homeostasis during Acute Babesia canis Infection in Dogs1820-744810.2478/acve-2021-0014https://doaj.org/article/c5ba7a32cb2349c982666253249ef7a62021-06-01T00:00:00Zhttps://doi.org/10.2478/acve-2021-0014https://doaj.org/toc/1820-7448Hemolysis and systemic acute inflammation characterize canine babesiosis caused by the intraerythrocytic protozoan parasite Babesia canis. Our hypothesis was that blood redox homeostasis of patients that suffered acute B. canis infection might be disturbed even after treatment with imidocarb-dipropionate and successful clinical recovery. Eight owner dogs with acute B. canis infection were used for this study. We analyzed the complete blood count, acute phase proteins (ceruloplasmin, haptoglobin, paraoxonase-1) in the serum, antioxidant enzymes (catalase and glutathione peroxidase) in the erythrocytes, and oxidative stress markers (malondialdehyde in erythrocytes and thiol groups in serum) at presentation and 15 days after treatment. Results were evaluated by corresponding statistical tests. At presentation, anemia, low/normal leukocyte count and severe thrombocytopenia occurred together with increased ceruloplasmin, haptoglobin levels within the reference interval, decreased paraoxonase-1 and compromised antioxidant defense in the red blood cells. After treatment and successful clinical recovery, hematological values generally fitted within the reference intervals, acute phase proteins were within the physiological levels in the majority of cases and the activities of the antioxidant enzymes were increased. However, elevated malondialdehyde levels indicated increased oxidative damage of erythrocytes that remained as a deleterious sequel despite a successful clinical recovery of the dogs.Spariosu KristinaJanjić FilipAndrić Jelena FrancuskiRadaković MilenaBeletić AnđeloFilipović Milica KovačevićMilanović SvetlanaSciendoarticleacute phase proteinsbabesiosiserythrocytesinflammationoxidative stressVeterinary medicineSF600-1100ENActa Veterinaria, Vol 71, Iss 2, Pp 158-169 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acute phase proteins babesiosis erythrocytes inflammation oxidative stress Veterinary medicine SF600-1100
spellingShingle	acute phase proteins babesiosis erythrocytes inflammation oxidative stress Veterinary medicine SF600-1100 Spariosu Kristina Janjić Filip Andrić Jelena Francuski Radaković Milena Beletić Anđelo Filipović Milica Kovačević Milanović Svetlana Relationship between Changes in Hematological Parameters, Levels of Acute Phase Proteins and Redox Homeostasis during Acute Babesia canis Infection in Dogs
description	Hemolysis and systemic acute inflammation characterize canine babesiosis caused by the intraerythrocytic protozoan parasite Babesia canis. Our hypothesis was that blood redox homeostasis of patients that suffered acute B. canis infection might be disturbed even after treatment with imidocarb-dipropionate and successful clinical recovery. Eight owner dogs with acute B. canis infection were used for this study. We analyzed the complete blood count, acute phase proteins (ceruloplasmin, haptoglobin, paraoxonase-1) in the serum, antioxidant enzymes (catalase and glutathione peroxidase) in the erythrocytes, and oxidative stress markers (malondialdehyde in erythrocytes and thiol groups in serum) at presentation and 15 days after treatment. Results were evaluated by corresponding statistical tests. At presentation, anemia, low/normal leukocyte count and severe thrombocytopenia occurred together with increased ceruloplasmin, haptoglobin levels within the reference interval, decreased paraoxonase-1 and compromised antioxidant defense in the red blood cells. After treatment and successful clinical recovery, hematological values generally fitted within the reference intervals, acute phase proteins were within the physiological levels in the majority of cases and the activities of the antioxidant enzymes were increased. However, elevated malondialdehyde levels indicated increased oxidative damage of erythrocytes that remained as a deleterious sequel despite a successful clinical recovery of the dogs.
format	article
author	Spariosu Kristina Janjić Filip Andrić Jelena Francuski Radaković Milena Beletić Anđelo Filipović Milica Kovačević Milanović Svetlana
author_facet	Spariosu Kristina Janjić Filip Andrić Jelena Francuski Radaković Milena Beletić Anđelo Filipović Milica Kovačević Milanović Svetlana
author_sort	Spariosu Kristina
title	Relationship between Changes in Hematological Parameters, Levels of Acute Phase Proteins and Redox Homeostasis during Acute Babesia canis Infection in Dogs
title_short	Relationship between Changes in Hematological Parameters, Levels of Acute Phase Proteins and Redox Homeostasis during Acute Babesia canis Infection in Dogs
title_full	Relationship between Changes in Hematological Parameters, Levels of Acute Phase Proteins and Redox Homeostasis during Acute Babesia canis Infection in Dogs
title_fullStr	Relationship between Changes in Hematological Parameters, Levels of Acute Phase Proteins and Redox Homeostasis during Acute Babesia canis Infection in Dogs
title_full_unstemmed	Relationship between Changes in Hematological Parameters, Levels of Acute Phase Proteins and Redox Homeostasis during Acute Babesia canis Infection in Dogs
title_sort	relationship between changes in hematological parameters, levels of acute phase proteins and redox homeostasis during acute babesia canis infection in dogs
publisher	Sciendo
publishDate	2021
url	https://doaj.org/article/c5ba7a32cb2349c982666253249ef7a6
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Relationship between Changes in Hematological Parameters, Levels of Acute Phase Proteins and Redox Homeostasis during Acute Babesia canis Infection in Dogs

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