The effect of fluoxetine and imipramine on the improvement of depressive-like behaviors and HPA axis (hypothalamic-pituitary-adrenal cortex) activity – an animal model

Depression is one of the most common mental disorders and numerous medications are used to reduce the psychotic symptoms. The aim of this study was to evaluate the therapeutic effects of two commonly used antidepressant drugs, including Fluoxetine (Flx) and Imipramine (IMP) to improve depressive-l...

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Autores principales:	Raghad Abdulsalam Khaleel, Saja Majeed Shareef, Zinah Essam Hameed, Khulood Majid Alsaraf, Maadh Fawzi Nassar
Formato:	article
Lenguaje:	EN
Publicado:	PC Technology Center 2021
Materias:	depressive-like behaviors hpa axis fluoxetine imipramine animal model Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/c5be27e2fb8d400da6bcdf3756af9b6e
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spelling	oai:doaj.org-article:c5be27e2fb8d400da6bcdf3756af9b6e2021-11-04T14:22:47ZThe effect of fluoxetine and imipramine on the improvement of depressive-like behaviors and HPA axis (hypothalamic-pituitary-adrenal cortex) activity – an animal model2519-48442519-485210.15587/2519-4852.2021.243526https://doaj.org/article/c5be27e2fb8d400da6bcdf3756af9b6e2021-10-01T00:00:00Zhttp://journals.uran.ua/sr_pharm/article/view/243526https://doaj.org/toc/2519-4844https://doaj.org/toc/2519-4852Depression is one of the most common mental disorders and numerous medications are used to reduce the psychotic symptoms. The aim of this study was to evaluate the therapeutic effects of two commonly used antidepressant drugs, including Fluoxetine (Flx) and Imipramine (IMP) to improve depressive-like behaviors as well as the activity of hypothalamic pituitary-adrenal cortex (HPA). Methods: Initially, 40 adult male albino rats weighing 25±5g were selected for this experimental study. The animals were kept or housed in separate cages under standard temperature (25±1°C) and light-dark conditions (12 hours light/dark cycle). Rats were divided into four groups: each group containing 10 rats, control, immobility stress, Flx receiver, and IMP receiver. Polyethylene restrainer was used to induce immobility stress for 14 days. Finally, the parameters of IMT, ST, serum levels of corticosterone and glucose were evaluated in all four mentioned groups. Results: The results showed that the patient group's immobility time (IMT) increased compared to the control group, but the patient group's swimming time (ST) decreased compared to the control group. The effect of immobility stress on IMT, ST, corticosterone, and glucose factors in the patient group was increasing and decreasing, respectively, whereas the effect of Flx drug on these mentioned factors was decreasing, increasing and respectively, while the effect of IMP on all mentioned factors was decreasing and increasing, respectively. Conclusion: Based on the results, it can be concluded that the antidepressant Flx and IMP drugs have various effects on the HPA activity, and the application of immobility stress causes depressive-behavior. Moreover, Flx is more effective than IMP in the treatment of depressive behaviorsRaghad Abdulsalam KhaleelSaja Majeed ShareefZinah Essam HameedKhulood Majid AlsarafMaadh Fawzi NassarPC Technology Centerarticledepressive-like behaviorshpa axisfluoxetineimipramineanimal modelPharmacy and materia medicaRS1-441ENScienceRise: Pharmaceutical Science, Iss 5(33), Pp 79-88 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	depressive-like behaviors hpa axis fluoxetine imipramine animal model Pharmacy and materia medica RS1-441
spellingShingle	depressive-like behaviors hpa axis fluoxetine imipramine animal model Pharmacy and materia medica RS1-441 Raghad Abdulsalam Khaleel Saja Majeed Shareef Zinah Essam Hameed Khulood Majid Alsaraf Maadh Fawzi Nassar The effect of fluoxetine and imipramine on the improvement of depressive-like behaviors and HPA axis (hypothalamic-pituitary-adrenal cortex) activity – an animal model
description	Depression is one of the most common mental disorders and numerous medications are used to reduce the psychotic symptoms. The aim of this study was to evaluate the therapeutic effects of two commonly used antidepressant drugs, including Fluoxetine (Flx) and Imipramine (IMP) to improve depressive-like behaviors as well as the activity of hypothalamic pituitary-adrenal cortex (HPA). Methods: Initially, 40 adult male albino rats weighing 25±5g were selected for this experimental study. The animals were kept or housed in separate cages under standard temperature (25±1°C) and light-dark conditions (12 hours light/dark cycle). Rats were divided into four groups: each group containing 10 rats, control, immobility stress, Flx receiver, and IMP receiver. Polyethylene restrainer was used to induce immobility stress for 14 days. Finally, the parameters of IMT, ST, serum levels of corticosterone and glucose were evaluated in all four mentioned groups. Results: The results showed that the patient group's immobility time (IMT) increased compared to the control group, but the patient group's swimming time (ST) decreased compared to the control group. The effect of immobility stress on IMT, ST, corticosterone, and glucose factors in the patient group was increasing and decreasing, respectively, whereas the effect of Flx drug on these mentioned factors was decreasing, increasing and respectively, while the effect of IMP on all mentioned factors was decreasing and increasing, respectively. Conclusion: Based on the results, it can be concluded that the antidepressant Flx and IMP drugs have various effects on the HPA activity, and the application of immobility stress causes depressive-behavior. Moreover, Flx is more effective than IMP in the treatment of depressive behaviors
format	article
author	Raghad Abdulsalam Khaleel Saja Majeed Shareef Zinah Essam Hameed Khulood Majid Alsaraf Maadh Fawzi Nassar
author_facet	Raghad Abdulsalam Khaleel Saja Majeed Shareef Zinah Essam Hameed Khulood Majid Alsaraf Maadh Fawzi Nassar
author_sort	Raghad Abdulsalam Khaleel
title	The effect of fluoxetine and imipramine on the improvement of depressive-like behaviors and HPA axis (hypothalamic-pituitary-adrenal cortex) activity – an animal model
title_short	The effect of fluoxetine and imipramine on the improvement of depressive-like behaviors and HPA axis (hypothalamic-pituitary-adrenal cortex) activity – an animal model
title_full	The effect of fluoxetine and imipramine on the improvement of depressive-like behaviors and HPA axis (hypothalamic-pituitary-adrenal cortex) activity – an animal model
title_fullStr	The effect of fluoxetine and imipramine on the improvement of depressive-like behaviors and HPA axis (hypothalamic-pituitary-adrenal cortex) activity – an animal model
title_full_unstemmed	The effect of fluoxetine and imipramine on the improvement of depressive-like behaviors and HPA axis (hypothalamic-pituitary-adrenal cortex) activity – an animal model
title_sort	effect of fluoxetine and imipramine on the improvement of depressive-like behaviors and hpa axis (hypothalamic-pituitary-adrenal cortex) activity – an animal model
publisher	PC Technology Center
publishDate	2021
url	https://doaj.org/article/c5be27e2fb8d400da6bcdf3756af9b6e
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The effect of fluoxetine and imipramine on the improvement of depressive-like behaviors and HPA axis (hypothalamic-pituitary-adrenal cortex) activity – an animal model

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