Immunoproteasome expression is associated with better prognosis and response to checkpoint therapies in melanoma

The response to immunotherapy of melanoma patients is heterogeneous. Here, the authors demonstrate that a high expression of the two major components of the immunoproteasome, PSMB8 and PSMB9, modulates the production of HLA peptides and it is predictive of better survival and improved response to im...

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Autores principales:	Shelly Kalaora, Joo Sang Lee, Eilon Barnea, Ronen Levy, Polina Greenberg, Michal Alon, Gal Yagel, Gitit Bar Eli, Roni Oren, Aviyah Peri, Sushant Patkar, Lital Bitton, Steven A. Rosenberg, Michal Lotem, Yishai Levin, Arie Admon, Eytan Ruppin, Yardena Samuels
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c5c1da08d4014458bca5479e40d5cf1c
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spelling	oai:doaj.org-article:c5c1da08d4014458bca5479e40d5cf1c2021-12-02T14:40:50ZImmunoproteasome expression is associated with better prognosis and response to checkpoint therapies in melanoma10.1038/s41467-020-14639-92041-1723https://doaj.org/article/c5c1da08d4014458bca5479e40d5cf1c2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14639-9https://doaj.org/toc/2041-1723The response to immunotherapy of melanoma patients is heterogeneous. Here, the authors demonstrate that a high expression of the two major components of the immunoproteasome, PSMB8 and PSMB9, modulates the production of HLA peptides and it is predictive of better survival and improved response to immune-checkpoint inhibitors of melanoma patients.Shelly KalaoraJoo Sang LeeEilon BarneaRonen LevyPolina GreenbergMichal AlonGal YagelGitit Bar EliRoni OrenAviyah PeriSushant PatkarLital BittonSteven A. RosenbergMichal LotemYishai LevinArie AdmonEytan RuppinYardena SamuelsNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shelly Kalaora Joo Sang Lee Eilon Barnea Ronen Levy Polina Greenberg Michal Alon Gal Yagel Gitit Bar Eli Roni Oren Aviyah Peri Sushant Patkar Lital Bitton Steven A. Rosenberg Michal Lotem Yishai Levin Arie Admon Eytan Ruppin Yardena Samuels Immunoproteasome expression is associated with better prognosis and response to checkpoint therapies in melanoma
description	The response to immunotherapy of melanoma patients is heterogeneous. Here, the authors demonstrate that a high expression of the two major components of the immunoproteasome, PSMB8 and PSMB9, modulates the production of HLA peptides and it is predictive of better survival and improved response to immune-checkpoint inhibitors of melanoma patients.
format	article
author	Shelly Kalaora Joo Sang Lee Eilon Barnea Ronen Levy Polina Greenberg Michal Alon Gal Yagel Gitit Bar Eli Roni Oren Aviyah Peri Sushant Patkar Lital Bitton Steven A. Rosenberg Michal Lotem Yishai Levin Arie Admon Eytan Ruppin Yardena Samuels
author_facet	Shelly Kalaora Joo Sang Lee Eilon Barnea Ronen Levy Polina Greenberg Michal Alon Gal Yagel Gitit Bar Eli Roni Oren Aviyah Peri Sushant Patkar Lital Bitton Steven A. Rosenberg Michal Lotem Yishai Levin Arie Admon Eytan Ruppin Yardena Samuels
author_sort	Shelly Kalaora
title	Immunoproteasome expression is associated with better prognosis and response to checkpoint therapies in melanoma
title_short	Immunoproteasome expression is associated with better prognosis and response to checkpoint therapies in melanoma
title_full	Immunoproteasome expression is associated with better prognosis and response to checkpoint therapies in melanoma
title_fullStr	Immunoproteasome expression is associated with better prognosis and response to checkpoint therapies in melanoma
title_full_unstemmed	Immunoproteasome expression is associated with better prognosis and response to checkpoint therapies in melanoma
title_sort	immunoproteasome expression is associated with better prognosis and response to checkpoint therapies in melanoma
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c5c1da08d4014458bca5479e40d5cf1c
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Immunoproteasome expression is associated with better prognosis and response to checkpoint therapies in melanoma

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