Immunoproteasome expression is associated with better prognosis and response to checkpoint therapies in melanoma
The response to immunotherapy of melanoma patients is heterogeneous. Here, the authors demonstrate that a high expression of the two major components of the immunoproteasome, PSMB8 and PSMB9, modulates the production of HLA peptides and it is predictive of better survival and improved response to im...
Saved in:
Main Authors: | Shelly Kalaora, Joo Sang Lee, Eilon Barnea, Ronen Levy, Polina Greenberg, Michal Alon, Gal Yagel, Gitit Bar Eli, Roni Oren, Aviyah Peri, Sushant Patkar, Lital Bitton, Steven A. Rosenberg, Michal Lotem, Yishai Levin, Arie Admon, Eytan Ruppin, Yardena Samuels |
---|---|
Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2020
|
Subjects: | |
Online Access: | https://doaj.org/article/c5c1da08d4014458bca5479e40d5cf1c |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
On the Role of the Immunoproteasome in Protein Homeostasis
by: Michael Basler, et al.
Published: (2021) -
20S immunoproteasomes remove formaldehyde-damaged cytoplasmic proteins suppressing caspase-independent cell death
by: Sara Ortega-Atienza, et al.
Published: (2017) -
Corneal wound healing is compromised by immunoproteasome deficiency.
by: Deborah A Ferrington, et al.
Published: (2013) -
mTORC1 accelerates retinal development via the immunoproteasome
by: Ji-Heon Choi, et al.
Published: (2018) -
Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes
by: Ruda de Luna Almeida Santos, et al.
Published: (2017)