Value of <sup>18</sup>F-FDG PET/CT for Assessment of Advanced Lacrimal Sac Non-Keratinizing Squamous Cell Carcinoma Successfully Treated with Concurrent Chemoradiotherapy

Non-keratinizing squamous cell carcinoma (NKSCC) of the lacrimal apparatus is extremely rare. It is usually very aggressive in destroying local tissue and has a grave prognosis for relentless recurrence and distant failures. Though the current evidence cannot make confident recommendations regarding...

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Autores principales:	Ching-Yu Liao, Li-An Huang, Yu-Hsuan Lin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<sup>18</sup>F-FDG PET/CT NKSCC concurrent chemo-radiotherapy lacrimal sac Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c5c5c7a2d2404e5da599aa536b33652e
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spelling	oai:doaj.org-article:c5c5c7a2d2404e5da599aa536b33652e2021-11-25T17:20:18ZValue of <sup>18</sup>F-FDG PET/CT for Assessment of Advanced Lacrimal Sac Non-Keratinizing Squamous Cell Carcinoma Successfully Treated with Concurrent Chemoradiotherapy10.3390/diagnostics111119612075-4418https://doaj.org/article/c5c5c7a2d2404e5da599aa536b33652e2021-10-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/1961https://doaj.org/toc/2075-4418Non-keratinizing squamous cell carcinoma (NKSCC) of the lacrimal apparatus is extremely rare. It is usually very aggressive in destroying local tissue and has a grave prognosis for relentless recurrence and distant failures. Though the current evidence cannot make confident recommendations regarding the best management, curative surgical excision with adjuvant radiotherapy remains the most commonly used strategy. Here, we report a 71-year-old woman presented with progressive right medial canthal swellings for six months. A transnasal endoscopic biopsy revealed NKSCC of the lacrimal sac. She then underwent a combination of magnetic resonance images (MRI) and 2-deoxy-2-(18F)fluoro-D-glucose positron emission tomography/computed tomography (<sup>18</sup>F-FDG PET/CT) for staging purposes. Following cisplatin-based concurrent chemo-radiotherapy (CCRT), the post-treatment PET/CT illustrated the absence of an abnormal metabolic accumulation over the suspicious region as observed in post-treatment CT. A further trans-ostia re-biopsy confirmed complete tumor remission. This case demonstrates the remarkable ability of <sup>18</sup>F-FDG PET/CT to differentiate between a persistent malignancy and post-treatment changes. Furthermore, a definite CCRT might provide comparable outcomes to traditional surgery.Ching-Yu LiaoLi-An HuangYu-Hsuan LinMDPI AGarticle<sup>18</sup>F-FDG PET/CTNKSCCconcurrent chemo-radiotherapylacrimal sacMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 1961, p 1961 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<sup>18</sup>F-FDG PET/CT NKSCC concurrent chemo-radiotherapy lacrimal sac Medicine (General) R5-920
spellingShingle	<sup>18</sup>F-FDG PET/CT NKSCC concurrent chemo-radiotherapy lacrimal sac Medicine (General) R5-920 Ching-Yu Liao Li-An Huang Yu-Hsuan Lin Value of <sup>18</sup>F-FDG PET/CT for Assessment of Advanced Lacrimal Sac Non-Keratinizing Squamous Cell Carcinoma Successfully Treated with Concurrent Chemoradiotherapy
description	Non-keratinizing squamous cell carcinoma (NKSCC) of the lacrimal apparatus is extremely rare. It is usually very aggressive in destroying local tissue and has a grave prognosis for relentless recurrence and distant failures. Though the current evidence cannot make confident recommendations regarding the best management, curative surgical excision with adjuvant radiotherapy remains the most commonly used strategy. Here, we report a 71-year-old woman presented with progressive right medial canthal swellings for six months. A transnasal endoscopic biopsy revealed NKSCC of the lacrimal sac. She then underwent a combination of magnetic resonance images (MRI) and 2-deoxy-2-(18F)fluoro-D-glucose positron emission tomography/computed tomography (<sup>18</sup>F-FDG PET/CT) for staging purposes. Following cisplatin-based concurrent chemo-radiotherapy (CCRT), the post-treatment PET/CT illustrated the absence of an abnormal metabolic accumulation over the suspicious region as observed in post-treatment CT. A further trans-ostia re-biopsy confirmed complete tumor remission. This case demonstrates the remarkable ability of <sup>18</sup>F-FDG PET/CT to differentiate between a persistent malignancy and post-treatment changes. Furthermore, a definite CCRT might provide comparable outcomes to traditional surgery.
format	article
author	Ching-Yu Liao Li-An Huang Yu-Hsuan Lin
author_facet	Ching-Yu Liao Li-An Huang Yu-Hsuan Lin
author_sort	Ching-Yu Liao
title	Value of <sup>18</sup>F-FDG PET/CT for Assessment of Advanced Lacrimal Sac Non-Keratinizing Squamous Cell Carcinoma Successfully Treated with Concurrent Chemoradiotherapy
title_short	Value of <sup>18</sup>F-FDG PET/CT for Assessment of Advanced Lacrimal Sac Non-Keratinizing Squamous Cell Carcinoma Successfully Treated with Concurrent Chemoradiotherapy
title_full	Value of <sup>18</sup>F-FDG PET/CT for Assessment of Advanced Lacrimal Sac Non-Keratinizing Squamous Cell Carcinoma Successfully Treated with Concurrent Chemoradiotherapy
title_fullStr	Value of <sup>18</sup>F-FDG PET/CT for Assessment of Advanced Lacrimal Sac Non-Keratinizing Squamous Cell Carcinoma Successfully Treated with Concurrent Chemoradiotherapy
title_full_unstemmed	Value of <sup>18</sup>F-FDG PET/CT for Assessment of Advanced Lacrimal Sac Non-Keratinizing Squamous Cell Carcinoma Successfully Treated with Concurrent Chemoradiotherapy
title_sort	value of <sup>18</sup>f-fdg pet/ct for assessment of advanced lacrimal sac non-keratinizing squamous cell carcinoma successfully treated with concurrent chemoradiotherapy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c5c5c7a2d2404e5da599aa536b33652e
work_keys_str_mv	AT chingyuliao valueofsup18supffdgpetctforassessmentofadvancedlacrimalsacnonkeratinizingsquamouscellcarcinomasuccessfullytreatedwithconcurrentchemoradiotherapy AT lianhuang valueofsup18supffdgpetctforassessmentofadvancedlacrimalsacnonkeratinizingsquamouscellcarcinomasuccessfullytreatedwithconcurrentchemoradiotherapy AT yuhsuanlin valueofsup18supffdgpetctforassessmentofadvancedlacrimalsacnonkeratinizingsquamouscellcarcinomasuccessfullytreatedwithconcurrentchemoradiotherapy
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Value of <sup>18</sup>F-FDG PET/CT for Assessment of Advanced Lacrimal Sac Non-Keratinizing Squamous Cell Carcinoma Successfully Treated with Concurrent Chemoradiotherapy

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