Metabolism

Physical exercise evokes mechanical loading conditions and thereby controls a diversity of physiological and biological reactions ranging from improved endurance capacity to increased muscle strength.This holds true for the endothelial cell system, which is controlled by exercise-dependent shear for...

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Autor principal: Suhr F
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Publicado: Dynamic Media Sales Verlag 2019
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Acceso en línea:https://doaj.org/article/c5cad84974de439a882a90a692acfa9f
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spelling oai:doaj.org-article:c5cad84974de439a882a90a692acfa9f2021-11-16T19:01:41ZMetabolism0344-59252510-526410.5960/dzsm.2019.367https://doaj.org/article/c5cad84974de439a882a90a692acfa9f2019-04-01T00:00:00Zhttps://www.germanjournalsportsmedicine.com/archiv/archiv-2019/issue-4/extracellular-matrix-proteases-and-physical-exercise/https://doaj.org/toc/0344-5925https://doaj.org/toc/2510-5264Physical exercise evokes mechanical loading conditions and thereby controls a diversity of physiological and biological reactions ranging from improved endurance capacity to increased muscle strength.This holds true for the endothelial cell system, which is controlled by exercise-dependent shear forces and for the skeletal muscle system subjected to mechanical loading. Shear forces/mechanical loading result in the activation of proteolytic enzymes, called proteases, which are capable of remodeling the central mechanosensitive cell scaffold, the extracellular matrix (ECM). Remodeling of ECM components evokes the release of cleavage fragments. These cleavage fragments in turn exert defined biological functions, such as angiogenesis modulation, nitric oxide generation or muscle regulation. This mini-review (i) describes the main players involved in this processing cascade and discusses the influence of physical exercise on mechanisms of ECM remodeling in the endothelial cell and muscle systems and (ii) discusses influences of societal challenges, such as aging or chronic diseases on ECM remodeling. KEY WORDS: ECM, Exercise, Endothelial Cells, Skeletal MuscleSuhr FDynamic Media Sales VerlagarticleSports medicineRC1200-1245DEENDeutsche Zeitschrift für Sportmedizin, Vol 70, Iss 4 (2019)
institution DOAJ
collection DOAJ
language DE
EN
topic Sports medicine
RC1200-1245
spellingShingle Sports medicine
RC1200-1245
Suhr F
Metabolism
description Physical exercise evokes mechanical loading conditions and thereby controls a diversity of physiological and biological reactions ranging from improved endurance capacity to increased muscle strength.This holds true for the endothelial cell system, which is controlled by exercise-dependent shear forces and for the skeletal muscle system subjected to mechanical loading. Shear forces/mechanical loading result in the activation of proteolytic enzymes, called proteases, which are capable of remodeling the central mechanosensitive cell scaffold, the extracellular matrix (ECM). Remodeling of ECM components evokes the release of cleavage fragments. These cleavage fragments in turn exert defined biological functions, such as angiogenesis modulation, nitric oxide generation or muscle regulation. This mini-review (i) describes the main players involved in this processing cascade and discusses the influence of physical exercise on mechanisms of ECM remodeling in the endothelial cell and muscle systems and (ii) discusses influences of societal challenges, such as aging or chronic diseases on ECM remodeling. KEY WORDS: ECM, Exercise, Endothelial Cells, Skeletal Muscle
format article
author Suhr F
author_facet Suhr F
author_sort Suhr F
title Metabolism
title_short Metabolism
title_full Metabolism
title_fullStr Metabolism
title_full_unstemmed Metabolism
title_sort metabolism
publisher Dynamic Media Sales Verlag
publishDate 2019
url https://doaj.org/article/c5cad84974de439a882a90a692acfa9f
work_keys_str_mv AT suhrf metabolism
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