Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis

Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis

The hypothalamic-pituitary-thyroid (HPT) axis regulates a wide range of physiological processes. Here the authors show that hypothalamic tanycytes play a role in the homeostatic regulation of the HPT axis; activation of TRH signaling in tanycytes elevates their intracellular Ca2+ via Gαq/11 pathway,...

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Autores principales: Helge Müller-Fielitz, Marcus Stahr, Mareike Bernau, Marius Richter, Sebastian Abele, Victor Krajka, Anika Benzin, Jan Wenzel, Kathrin Kalies, Jens Mittag, Heike Heuer, Stefan Offermanns, Markus Schwaninger
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/c5cc71a5e3d64ec38fd693c1f9663f55
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spelling oai:doaj.org-article:c5cc71a5e3d64ec38fd693c1f9663f552021-12-02T14:42:36ZTanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis10.1038/s41467-017-00604-62041-1723https://doaj.org/article/c5cc71a5e3d64ec38fd693c1f9663f552017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00604-6https://doaj.org/toc/2041-1723The hypothalamic-pituitary-thyroid (HPT) axis regulates a wide range of physiological processes. Here the authors show that hypothalamic tanycytes play a role in the homeostatic regulation of the HPT axis; activation of TRH signaling in tanycytes elevates their intracellular Ca2+ via Gαq/11 pathway, ultimately resulting in reduced TRH release into the pituitary vessels.Helge Müller-FielitzMarcus StahrMareike BernauMarius RichterSebastian AbeleVictor KrajkaAnika BenzinJan WenzelKathrin KaliesJens MittagHeike HeuerStefan OffermannsMarkus SchwaningerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Helge Müller-Fielitz
Marcus Stahr
Mareike Bernau
Marius Richter
Sebastian Abele
Victor Krajka
Anika Benzin
Jan Wenzel
Kathrin Kalies
Jens Mittag
Heike Heuer
Stefan Offermanns
Markus Schwaninger
Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis
description The hypothalamic-pituitary-thyroid (HPT) axis regulates a wide range of physiological processes. Here the authors show that hypothalamic tanycytes play a role in the homeostatic regulation of the HPT axis; activation of TRH signaling in tanycytes elevates their intracellular Ca2+ via Gαq/11 pathway, ultimately resulting in reduced TRH release into the pituitary vessels.
format article
author Helge Müller-Fielitz
Marcus Stahr
Mareike Bernau
Marius Richter
Sebastian Abele
Victor Krajka
Anika Benzin
Jan Wenzel
Kathrin Kalies
Jens Mittag
Heike Heuer
Stefan Offermanns
Markus Schwaninger
author_facet Helge Müller-Fielitz
Marcus Stahr
Mareike Bernau
Marius Richter
Sebastian Abele
Victor Krajka
Anika Benzin
Jan Wenzel
Kathrin Kalies
Jens Mittag
Heike Heuer
Stefan Offermanns
Markus Schwaninger
author_sort Helge Müller-Fielitz
title Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis
title_short Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis
title_full Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis
title_fullStr Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis
title_full_unstemmed Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis
title_sort tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/c5cc71a5e3d64ec38fd693c1f9663f55
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