Verapamil administration alleviates microcytosis and tissue accumulation after chronic aluminum exposure in rats

Introduction/Objective. Research has demonstrated the toxicant potential of aluminum, but no therapeutic options have been suggested. The aim of the study was to investigate the extent of the aluminuminduced toxicity, evaluated by hematological/biochemical disarrangements, hepcidin concentration and...

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Autores principales:	Bojanić Novica, Stojanović Dijana, Milojković Maja, Đinđić Boris, Dunjić Olivera, Milenković Jelena, Ignjatović Aleksandra, Stojanović Marko
Formato:	article
Lenguaje:	EN SR
Publicado:	Serbian Medical Society 2021
Materias:	aluminum-induced toxicity verapamil chronic exposure hepcidin microcytosis Medicine R
Acceso en línea:	https://doaj.org/article/c5d655aa406944c198ddc26aefe82b85
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spelling	oai:doaj.org-article:c5d655aa406944c198ddc26aefe82b852021-11-10T07:28:09ZVerapamil administration alleviates microcytosis and tissue accumulation after chronic aluminum exposure in rats0370-81792406-089510.2298/SARH210322044Bhttps://doaj.org/article/c5d655aa406944c198ddc26aefe82b852021-01-01T00:00:00Zhttp://www.doiserbia.nb.rs/img/doi/0370-8179/2021/0370-81792100044B.pdfhttps://doaj.org/toc/0370-8179https://doaj.org/toc/2406-0895Introduction/Objective. Research has demonstrated the toxicant potential of aluminum, but no therapeutic options have been suggested. The aim of the study was to investigate the extent of the aluminuminduced toxicity, evaluated by hematological/biochemical disarrangements, hepcidin concentration and tissue accumulation after chronic aluminum exposure and to determine possible protection with Ca2+-channel blockage, verapamil. Methods. Experimental animals (36 rats) were treated with different doses of AlCl3 during eight weeks and after that their blood and tissues were analyzed. Results. The significant differences, regardless of the aluminum dose administered, were documented in all evaluated hematological (p < 0.001) and biochemical parameters (p < 0.001), as well as in aluminum tissue deposition in liver, kidneys and testicles (p < 0.001), respectively. After verapamil administration, a significant improvement in some hematological and biochemical parameters was demonstrated, p < 0.001, as well as the attenuation of aluminum deposits in liver and testes, p < 0.001. Evaluated parameters of inflammation and kidney deposition did not show significant change after verapamil application. Conclusion. The findings indicate that chronic AlCl3 intoxication, regardless of the dose, results in the microcytic anemia associated with high hepcidin levels, numerous biochemical abnormalities and significant aluminum deposition in liver, kidney and testes and that these effects may be attenuated by verapamil administration. Overall, the results emphasize the significance of calcium homeostasis preservation in chronic aluminum exposure and propose possible therapeutic option.Bojanić NovicaStojanović DijanaMilojković MajaĐinđić BorisDunjić OliveraMilenković JelenaIgnjatović AleksandraStojanović MarkoSerbian Medical Societyarticlealuminum-induced toxicityverapamilchronic exposurehepcidinmicrocytosisMedicineRENSRSrpski Arhiv za Celokupno Lekarstvo, Vol 149, Iss 9-10, Pp 551-557 (2021)
institution	DOAJ
collection	DOAJ
language	EN SR
topic	aluminum-induced toxicity verapamil chronic exposure hepcidin microcytosis Medicine R
spellingShingle	aluminum-induced toxicity verapamil chronic exposure hepcidin microcytosis Medicine R Bojanić Novica Stojanović Dijana Milojković Maja Đinđić Boris Dunjić Olivera Milenković Jelena Ignjatović Aleksandra Stojanović Marko Verapamil administration alleviates microcytosis and tissue accumulation after chronic aluminum exposure in rats
description	Introduction/Objective. Research has demonstrated the toxicant potential of aluminum, but no therapeutic options have been suggested. The aim of the study was to investigate the extent of the aluminuminduced toxicity, evaluated by hematological/biochemical disarrangements, hepcidin concentration and tissue accumulation after chronic aluminum exposure and to determine possible protection with Ca2+-channel blockage, verapamil. Methods. Experimental animals (36 rats) were treated with different doses of AlCl3 during eight weeks and after that their blood and tissues were analyzed. Results. The significant differences, regardless of the aluminum dose administered, were documented in all evaluated hematological (p < 0.001) and biochemical parameters (p < 0.001), as well as in aluminum tissue deposition in liver, kidneys and testicles (p < 0.001), respectively. After verapamil administration, a significant improvement in some hematological and biochemical parameters was demonstrated, p < 0.001, as well as the attenuation of aluminum deposits in liver and testes, p < 0.001. Evaluated parameters of inflammation and kidney deposition did not show significant change after verapamil application. Conclusion. The findings indicate that chronic AlCl3 intoxication, regardless of the dose, results in the microcytic anemia associated with high hepcidin levels, numerous biochemical abnormalities and significant aluminum deposition in liver, kidney and testes and that these effects may be attenuated by verapamil administration. Overall, the results emphasize the significance of calcium homeostasis preservation in chronic aluminum exposure and propose possible therapeutic option.
format	article
author	Bojanić Novica Stojanović Dijana Milojković Maja Đinđić Boris Dunjić Olivera Milenković Jelena Ignjatović Aleksandra Stojanović Marko
author_facet	Bojanić Novica Stojanović Dijana Milojković Maja Đinđić Boris Dunjić Olivera Milenković Jelena Ignjatović Aleksandra Stojanović Marko
author_sort	Bojanić Novica
title	Verapamil administration alleviates microcytosis and tissue accumulation after chronic aluminum exposure in rats
title_short	Verapamil administration alleviates microcytosis and tissue accumulation after chronic aluminum exposure in rats
title_full	Verapamil administration alleviates microcytosis and tissue accumulation after chronic aluminum exposure in rats
title_fullStr	Verapamil administration alleviates microcytosis and tissue accumulation after chronic aluminum exposure in rats
title_full_unstemmed	Verapamil administration alleviates microcytosis and tissue accumulation after chronic aluminum exposure in rats
title_sort	verapamil administration alleviates microcytosis and tissue accumulation after chronic aluminum exposure in rats
publisher	Serbian Medical Society
publishDate	2021
url	https://doaj.org/article/c5d655aa406944c198ddc26aefe82b85
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Verapamil administration alleviates microcytosis and tissue accumulation after chronic aluminum exposure in rats

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