Association between serum uric acid and cardiovascular disease risk factors in adolescents in America: 2001-2018.

SUA is associated with cardiovascular disease and cardiovascular disease risk factors in adults, including chronic kidney disease, coronary artery disease, stroke, diabetes mellitus, preeclampsia, and hypertension. A cross-sectional study was carried out among 11219 adolescents 12 to 18 years of age...

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Autores principales:	Qiqi Shi, Ran Wang, Huifeng Zhang, Yaping Shan, Ming Ye, Bing Jia
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c5d7899e00374a05abe58330d58aeea9
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spelling	oai:doaj.org-article:c5d7899e00374a05abe58330d58aeea92021-12-02T20:17:40ZAssociation between serum uric acid and cardiovascular disease risk factors in adolescents in America: 2001-2018.1932-620310.1371/journal.pone.0254590https://doaj.org/article/c5d7899e00374a05abe58330d58aeea92021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254590https://doaj.org/toc/1932-6203SUA is associated with cardiovascular disease and cardiovascular disease risk factors in adults, including chronic kidney disease, coronary artery disease, stroke, diabetes mellitus, preeclampsia, and hypertension. A cross-sectional study was carried out among 11219 adolescents 12 to 18 years of age examined in the 2001-2018 National health and Nutrition Examination Survey. We examined the association between SUA and CVD risk factors. The overall mean SUA level was 5.00±1.24mg/dl. Restricted cubic spline analysis results revealed SUA was inversely associated with HDL-C and SPISE and positively associated with TC, TG, LDL-C, nonHDL-C, insulin, SBP and DBP after full adjustment. Multiple logistic analyses showed SUA level was independently associated with high TC, high TG, high nonHDL-C and low HDL-C (all p<0.05). Furthermore, females in the highest quartile of SUA had significantly higher odds for elevated BP (OR = 2.38, 95%CI:1.02-5.54, P<0.05) and high TC (OR = 2.22, 95%CI: 1.49-3.30, P<0.001), which not observed in males. Increased levels of SUA were associated with increased odds of various cardiovascular risk factors in American adolescents, especially females.Qiqi ShiRan WangHuifeng ZhangYaping ShanMing YeBing JiaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0254590 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Qiqi Shi Ran Wang Huifeng Zhang Yaping Shan Ming Ye Bing Jia Association between serum uric acid and cardiovascular disease risk factors in adolescents in America: 2001-2018.
description	SUA is associated with cardiovascular disease and cardiovascular disease risk factors in adults, including chronic kidney disease, coronary artery disease, stroke, diabetes mellitus, preeclampsia, and hypertension. A cross-sectional study was carried out among 11219 adolescents 12 to 18 years of age examined in the 2001-2018 National health and Nutrition Examination Survey. We examined the association between SUA and CVD risk factors. The overall mean SUA level was 5.00±1.24mg/dl. Restricted cubic spline analysis results revealed SUA was inversely associated with HDL-C and SPISE and positively associated with TC, TG, LDL-C, nonHDL-C, insulin, SBP and DBP after full adjustment. Multiple logistic analyses showed SUA level was independently associated with high TC, high TG, high nonHDL-C and low HDL-C (all p<0.05). Furthermore, females in the highest quartile of SUA had significantly higher odds for elevated BP (OR = 2.38, 95%CI:1.02-5.54, P<0.05) and high TC (OR = 2.22, 95%CI: 1.49-3.30, P<0.001), which not observed in males. Increased levels of SUA were associated with increased odds of various cardiovascular risk factors in American adolescents, especially females.
format	article
author	Qiqi Shi Ran Wang Huifeng Zhang Yaping Shan Ming Ye Bing Jia
author_facet	Qiqi Shi Ran Wang Huifeng Zhang Yaping Shan Ming Ye Bing Jia
author_sort	Qiqi Shi
title	Association between serum uric acid and cardiovascular disease risk factors in adolescents in America: 2001-2018.
title_short	Association between serum uric acid and cardiovascular disease risk factors in adolescents in America: 2001-2018.
title_full	Association between serum uric acid and cardiovascular disease risk factors in adolescents in America: 2001-2018.
title_fullStr	Association between serum uric acid and cardiovascular disease risk factors in adolescents in America: 2001-2018.
title_full_unstemmed	Association between serum uric acid and cardiovascular disease risk factors in adolescents in America: 2001-2018.
title_sort	association between serum uric acid and cardiovascular disease risk factors in adolescents in america: 2001-2018.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/c5d7899e00374a05abe58330d58aeea9
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Association between serum uric acid and cardiovascular disease risk factors in adolescents in America: 2001-2018.

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