Serum Copper and Zinc in a Representative Sample of Bulgarian Population

Copper (Cu) and zinc (Zn) are essential for life. Body Cu and Zn content depends on variety of factors - age, gender, and diet, type of drinking water, geographical location and genetic predisposition. Copper status becomes even more relevant not only in rare genetic disorders such as Wilson disease...

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Autores principales:	Ivanova I., Atanasova B., Kostadinova A., Bocheva Y., Tzatchev K.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2016
Materias:	copper zinc trace elements alzheimer’s disease Medicine R
Acceso en línea:	https://doaj.org/article/c5d9f53e82e14f108fb4b55c1b721caa
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spelling	oai:doaj.org-article:c5d9f53e82e14f108fb4b55c1b721caa2021-12-02T19:11:12ZSerum Copper and Zinc in a Representative Sample of Bulgarian Population0324-175010.1515/amb-2016-0013https://doaj.org/article/c5d9f53e82e14f108fb4b55c1b721caa2016-10-01T00:00:00Zhttps://doi.org/10.1515/amb-2016-0013https://doaj.org/toc/0324-1750Copper (Cu) and zinc (Zn) are essential for life. Body Cu and Zn content depends on variety of factors - age, gender, and diet, type of drinking water, geographical location and genetic predisposition. Copper status becomes even more relevant not only in rare genetic disorders such as Wilson disease but in diseases such as cardiovascular ones, impaired glucose tolerance and neuro-degenerative and tumor diseases. The study aimed to examine the distribution of serum Cu and Zn in a representative group of the Bulgarian population and to describe factors which influence metal content. It also aimed to describe the link between serum Cu levels and the frequency of Alzheimer’s disease (AD) in Bulgarians. Cu and Zn in serum were measured in 379 individuals (172 males and 207 females) from 5 different regions in Bulgaria by flame atomic absorption using AAnalyst 400, Perkin Elmer. Statistical analyses were performed by SPSS, 19. Median and inert-quartile range (IQR) for blood Cu were 15.89 (13.87-7.89) μmol/L and for Zn - 13.00 (11.7-14.68) μmol/L in the examined group. Higher Cu levels in females than in males were found (p < 0.001). Decrease of Zn with aging was established (p > 0.05). Significant difference (p < 0.05) was found in serum Cu between young people (< 30 year old) and adults over 61 year old. Statistically significant difference in Cu and Zn was observed (p < 0.05) in respect of residences. Difference without significance was measured between serum lipids and serum Cu (p = 0.541) and Zn (p = 0.741).Ivanova I.Atanasova B.Kostadinova A.Bocheva Y.Tzatchev K.Sciendoarticlecopperzinctrace elementsalzheimer’s diseaseMedicineRENActa Medica Bulgarica, Vol 43, Iss 2, Pp 21-31 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	copper zinc trace elements alzheimer’s disease Medicine R
spellingShingle	copper zinc trace elements alzheimer’s disease Medicine R Ivanova I. Atanasova B. Kostadinova A. Bocheva Y. Tzatchev K. Serum Copper and Zinc in a Representative Sample of Bulgarian Population
description	Copper (Cu) and zinc (Zn) are essential for life. Body Cu and Zn content depends on variety of factors - age, gender, and diet, type of drinking water, geographical location and genetic predisposition. Copper status becomes even more relevant not only in rare genetic disorders such as Wilson disease but in diseases such as cardiovascular ones, impaired glucose tolerance and neuro-degenerative and tumor diseases. The study aimed to examine the distribution of serum Cu and Zn in a representative group of the Bulgarian population and to describe factors which influence metal content. It also aimed to describe the link between serum Cu levels and the frequency of Alzheimer’s disease (AD) in Bulgarians. Cu and Zn in serum were measured in 379 individuals (172 males and 207 females) from 5 different regions in Bulgaria by flame atomic absorption using AAnalyst 400, Perkin Elmer. Statistical analyses were performed by SPSS, 19. Median and inert-quartile range (IQR) for blood Cu were 15.89 (13.87-7.89) μmol/L and for Zn - 13.00 (11.7-14.68) μmol/L in the examined group. Higher Cu levels in females than in males were found (p < 0.001). Decrease of Zn with aging was established (p > 0.05). Significant difference (p < 0.05) was found in serum Cu between young people (< 30 year old) and adults over 61 year old. Statistically significant difference in Cu and Zn was observed (p < 0.05) in respect of residences. Difference without significance was measured between serum lipids and serum Cu (p = 0.541) and Zn (p = 0.741).
format	article
author	Ivanova I. Atanasova B. Kostadinova A. Bocheva Y. Tzatchev K.
author_facet	Ivanova I. Atanasova B. Kostadinova A. Bocheva Y. Tzatchev K.
author_sort	Ivanova I.
title	Serum Copper and Zinc in a Representative Sample of Bulgarian Population
title_short	Serum Copper and Zinc in a Representative Sample of Bulgarian Population
title_full	Serum Copper and Zinc in a Representative Sample of Bulgarian Population
title_fullStr	Serum Copper and Zinc in a Representative Sample of Bulgarian Population
title_full_unstemmed	Serum Copper and Zinc in a Representative Sample of Bulgarian Population
title_sort	serum copper and zinc in a representative sample of bulgarian population
publisher	Sciendo
publishDate	2016
url	https://doaj.org/article/c5d9f53e82e14f108fb4b55c1b721caa
work_keys_str_mv	AT ivanovai serumcopperandzincinarepresentativesampleofbulgarianpopulation AT atanasovab serumcopperandzincinarepresentativesampleofbulgarianpopulation AT kostadinovaa serumcopperandzincinarepresentativesampleofbulgarianpopulation AT bochevay serumcopperandzincinarepresentativesampleofbulgarianpopulation AT tzatchevk serumcopperandzincinarepresentativesampleofbulgarianpopulation
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Serum Copper and Zinc in a Representative Sample of Bulgarian Population

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