A novel cascade allows Metarhizium robertsii to distinguish cuticle and hemocoel microenvironments during infection of insects.

Pathogenic fungi precisely respond to dynamic microenvironments during infection, but the underlying mechanisms are not well understood. The insect pathogenic fungus Metarhizium robertsii is a representative fungus in which to study broad themes of fungal pathogenicity as it resembles some major pla...

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Autores principales:	Xing Zhang, Yamin Meng, Yizhou Huang, Dan Zhang, Weiguo Fang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c5da4ed5aab64660928a217d6f5cd1a6
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spelling	oai:doaj.org-article:c5da4ed5aab64660928a217d6f5cd1a62021-12-02T19:54:40ZA novel cascade allows Metarhizium robertsii to distinguish cuticle and hemocoel microenvironments during infection of insects.1544-91731545-788510.1371/journal.pbio.3001360https://doaj.org/article/c5da4ed5aab64660928a217d6f5cd1a62021-08-01T00:00:00Zhttps://doi.org/10.1371/journal.pbio.3001360https://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Pathogenic fungi precisely respond to dynamic microenvironments during infection, but the underlying mechanisms are not well understood. The insect pathogenic fungus Metarhizium robertsii is a representative fungus in which to study broad themes of fungal pathogenicity as it resembles some major plant and mammalian pathogenic fungi in its pathogenesis. Here we report on a novel cascade that regulates response of M. robertsii to 2 distinct microenvironments during its pathogenesis. On the insect cuticle, the transcription factor COH2 activates expression of cuticle penetration genes. In the hemocoel, the protein COH1 is expressed due to the reduction in epigenetic repression conferred by the histone deacetylase HDAC1 and the histone 3 acetyltransferase HAT1. COH1 interacts with COH2 to reduce COH2 stability, and this down-regulates cuticle penetration genes and up-regulates genes for hemocoel colonization. Our work significantly advances the insights into fungal pathogenicity in insects.Xing ZhangYamin MengYizhou HuangDan ZhangWeiguo FangPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 19, Iss 8, p e3001360 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Xing Zhang Yamin Meng Yizhou Huang Dan Zhang Weiguo Fang A novel cascade allows Metarhizium robertsii to distinguish cuticle and hemocoel microenvironments during infection of insects.
description	Pathogenic fungi precisely respond to dynamic microenvironments during infection, but the underlying mechanisms are not well understood. The insect pathogenic fungus Metarhizium robertsii is a representative fungus in which to study broad themes of fungal pathogenicity as it resembles some major plant and mammalian pathogenic fungi in its pathogenesis. Here we report on a novel cascade that regulates response of M. robertsii to 2 distinct microenvironments during its pathogenesis. On the insect cuticle, the transcription factor COH2 activates expression of cuticle penetration genes. In the hemocoel, the protein COH1 is expressed due to the reduction in epigenetic repression conferred by the histone deacetylase HDAC1 and the histone 3 acetyltransferase HAT1. COH1 interacts with COH2 to reduce COH2 stability, and this down-regulates cuticle penetration genes and up-regulates genes for hemocoel colonization. Our work significantly advances the insights into fungal pathogenicity in insects.
format	article
author	Xing Zhang Yamin Meng Yizhou Huang Dan Zhang Weiguo Fang
author_facet	Xing Zhang Yamin Meng Yizhou Huang Dan Zhang Weiguo Fang
author_sort	Xing Zhang
title	A novel cascade allows Metarhizium robertsii to distinguish cuticle and hemocoel microenvironments during infection of insects.
title_short	A novel cascade allows Metarhizium robertsii to distinguish cuticle and hemocoel microenvironments during infection of insects.
title_full	A novel cascade allows Metarhizium robertsii to distinguish cuticle and hemocoel microenvironments during infection of insects.
title_fullStr	A novel cascade allows Metarhizium robertsii to distinguish cuticle and hemocoel microenvironments during infection of insects.
title_full_unstemmed	A novel cascade allows Metarhizium robertsii to distinguish cuticle and hemocoel microenvironments during infection of insects.
title_sort	novel cascade allows metarhizium robertsii to distinguish cuticle and hemocoel microenvironments during infection of insects.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/c5da4ed5aab64660928a217d6f5cd1a6
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A novel cascade allows Metarhizium robertsii to distinguish cuticle and hemocoel microenvironments during infection of insects.

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