External assessment of the EUROMACS right-sided heart failure risk score

Abstract The EUROMACS Right-Sided Heart Failure Risk Score was developed to predict right ventricular failure (RVF) after left ventricular assist device (LVAD) placement. The predictive ability of the EUROMACS score has not been tested in other cohorts. We performed a single center analysis of a con...

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Autores principales:	Hirak Shah, Thomas Murray, Jessica Schultz, Ranjit John, Cindy M. Martin, Thenappan Thenappan, Rebecca Cogswell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c5e3130bb105412d9d89b67d2e5ab1c4
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spelling	oai:doaj.org-article:c5e3130bb105412d9d89b67d2e5ab1c42021-12-02T15:08:10ZExternal assessment of the EUROMACS right-sided heart failure risk score10.1038/s41598-021-94792-32045-2322https://doaj.org/article/c5e3130bb105412d9d89b67d2e5ab1c42021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94792-3https://doaj.org/toc/2045-2322Abstract The EUROMACS Right-Sided Heart Failure Risk Score was developed to predict right ventricular failure (RVF) after left ventricular assist device (LVAD) placement. The predictive ability of the EUROMACS score has not been tested in other cohorts. We performed a single center analysis of a continuous-flow (CF) LVAD cohort (n = 254) where we calculated EUROMACS risk scores and assessed for right ventricular heart failure after LVAD implantation. Thirty-nine percent of patients (100/254) had post-operative RVF, of which 9% (23/254) required prolonged inotropic support and 5% (12/254) required RVAD placement. For patients who developed RVF after LVAD implantation, there was a 45% increase in the hazards of death on LVAD support (HR 1.45, 95% CI 0.98–2.2, p = 0.066). Two variables in the EUROMACS score (Hemoglobin and Right Atrial Pressure to Pulmonary Capillary Wedge Pressure ratio) were not predictive of RVF in our cohort. Overall, the EUROMACS score had poor external discrimination in our cohort with area under the curve of 58% (95% CI 52–66%). Further work is necessary to enhance our ability to predict RVF after LVAD implantation.Hirak ShahThomas MurrayJessica SchultzRanjit JohnCindy M. MartinThenappan ThenappanRebecca CogswellNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hirak Shah Thomas Murray Jessica Schultz Ranjit John Cindy M. Martin Thenappan Thenappan Rebecca Cogswell External assessment of the EUROMACS right-sided heart failure risk score
description	Abstract The EUROMACS Right-Sided Heart Failure Risk Score was developed to predict right ventricular failure (RVF) after left ventricular assist device (LVAD) placement. The predictive ability of the EUROMACS score has not been tested in other cohorts. We performed a single center analysis of a continuous-flow (CF) LVAD cohort (n = 254) where we calculated EUROMACS risk scores and assessed for right ventricular heart failure after LVAD implantation. Thirty-nine percent of patients (100/254) had post-operative RVF, of which 9% (23/254) required prolonged inotropic support and 5% (12/254) required RVAD placement. For patients who developed RVF after LVAD implantation, there was a 45% increase in the hazards of death on LVAD support (HR 1.45, 95% CI 0.98–2.2, p = 0.066). Two variables in the EUROMACS score (Hemoglobin and Right Atrial Pressure to Pulmonary Capillary Wedge Pressure ratio) were not predictive of RVF in our cohort. Overall, the EUROMACS score had poor external discrimination in our cohort with area under the curve of 58% (95% CI 52–66%). Further work is necessary to enhance our ability to predict RVF after LVAD implantation.
format	article
author	Hirak Shah Thomas Murray Jessica Schultz Ranjit John Cindy M. Martin Thenappan Thenappan Rebecca Cogswell
author_facet	Hirak Shah Thomas Murray Jessica Schultz Ranjit John Cindy M. Martin Thenappan Thenappan Rebecca Cogswell
author_sort	Hirak Shah
title	External assessment of the EUROMACS right-sided heart failure risk score
title_short	External assessment of the EUROMACS right-sided heart failure risk score
title_full	External assessment of the EUROMACS right-sided heart failure risk score
title_fullStr	External assessment of the EUROMACS right-sided heart failure risk score
title_full_unstemmed	External assessment of the EUROMACS right-sided heart failure risk score
title_sort	external assessment of the euromacs right-sided heart failure risk score
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c5e3130bb105412d9d89b67d2e5ab1c4
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External assessment of the EUROMACS right-sided heart failure risk score

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