Research progress in dynamic kinetic resolution of azlactone
With the rapid development of research and demand for chiral compounds, the synthesis of important small molecule compounds such as optically active amino acids has attracted more and more attention. In the presence of nucleophiles, azlactones with nitrogen-containing heterocyclic structures can und...
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| Autores principales: | , , , |
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| Formato: | article |
| Lenguaje: | EN ZH |
| Publicado: |
Academic Journals Center of Shanghai Normal University
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/c5e4941fc94c41838cdecfe20540e5c6 |
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| Sumario: | With the rapid development of research and demand for chiral compounds, the synthesis of important small molecule compounds such as optically active amino acids has attracted more and more attention. In the presence of nucleophiles, azlactones with nitrogen-containing heterocyclic structures can undergo ring-opening reactions such as hydrolysis, alcoholysis, thiolysis, and amination to obtain a series of chiral amino acids and their derivatives. Besides, the hydrogen atom at the position of the 4-carbon (C-4) is acidic and can undergo enol interconversion under certain conditions to make racemization easy. Therefore, azlactones are ideal substrates for dynamic kinetic resolution(DKR) reactions. This review describes the recent research progress in preparation of chiral amino acids and their derivatives by DKR of azlactone. |
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