Research progress in dynamic kinetic resolution of azlactone

With the rapid development of research and demand for chiral compounds, the synthesis of important small molecule compounds such as optically active amino acids has attracted more and more attention. In the presence of nucleophiles, azlactones with nitrogen-containing heterocyclic structures can und...

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Autores principales:	HUANG Renfu, LIU Qingwen, LIN Jingrong, CHENG Tanyu
Formato:	article
Lenguaje:	EN ZH
Publicado:	Academic Journals Center of Shanghai Normal University 2021
Materias:	azlactones dynamic kinetic resolution(dkr) chiral amino acid Science (General) Q1-390
Acceso en línea:	https://doaj.org/article/c5e4941fc94c41838cdecfe20540e5c6
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id	oai:doaj.org-article:c5e4941fc94c41838cdecfe20540e5c6
record_format	dspace
spelling	oai:doaj.org-article:c5e4941fc94c41838cdecfe20540e5c62021-11-12T03:34:00ZResearch progress in dynamic kinetic resolution of azlactone1000-513710.3969/J.ISSN.1000-5137.2021.05.015https://doaj.org/article/c5e4941fc94c41838cdecfe20540e5c62021-10-01T00:00:00Zhttp://qktg.shnu.edu.cn/zrb/shsfqkszrb/ch/reader/view_abstract.aspx?file_no=20210515https://doaj.org/toc/1000-5137With the rapid development of research and demand for chiral compounds, the synthesis of important small molecule compounds such as optically active amino acids has attracted more and more attention. In the presence of nucleophiles, azlactones with nitrogen-containing heterocyclic structures can undergo ring-opening reactions such as hydrolysis, alcoholysis, thiolysis, and amination to obtain a series of chiral amino acids and their derivatives. Besides, the hydrogen atom at the position of the 4-carbon (C-4) is acidic and can undergo enol interconversion under certain conditions to make racemization easy. Therefore, azlactones are ideal substrates for dynamic kinetic resolution(DKR) reactions. This review describes the recent research progress in preparation of chiral amino acids and their derivatives by DKR of azlactone.HUANG RenfuLIU QingwenLIN JingrongCHENG TanyuAcademic Journals Center of Shanghai Normal Universityarticleazlactonesdynamic kinetic resolution(dkr)chiral amino acidScience (General)Q1-390ENZHJournal of Shanghai Normal University (Natural Sciences), Vol 50, Iss 5, Pp 636-643 (2021)
institution	DOAJ
collection	DOAJ
language	EN ZH
topic	azlactones dynamic kinetic resolution(dkr) chiral amino acid Science (General) Q1-390
spellingShingle	azlactones dynamic kinetic resolution(dkr) chiral amino acid Science (General) Q1-390 HUANG Renfu LIU Qingwen LIN Jingrong CHENG Tanyu Research progress in dynamic kinetic resolution of azlactone
description	With the rapid development of research and demand for chiral compounds, the synthesis of important small molecule compounds such as optically active amino acids has attracted more and more attention. In the presence of nucleophiles, azlactones with nitrogen-containing heterocyclic structures can undergo ring-opening reactions such as hydrolysis, alcoholysis, thiolysis, and amination to obtain a series of chiral amino acids and their derivatives. Besides, the hydrogen atom at the position of the 4-carbon (C-4) is acidic and can undergo enol interconversion under certain conditions to make racemization easy. Therefore, azlactones are ideal substrates for dynamic kinetic resolution(DKR) reactions. This review describes the recent research progress in preparation of chiral amino acids and their derivatives by DKR of azlactone.
format	article
author	HUANG Renfu LIU Qingwen LIN Jingrong CHENG Tanyu
author_facet	HUANG Renfu LIU Qingwen LIN Jingrong CHENG Tanyu
author_sort	HUANG Renfu
title	Research progress in dynamic kinetic resolution of azlactone
title_short	Research progress in dynamic kinetic resolution of azlactone
title_full	Research progress in dynamic kinetic resolution of azlactone
title_fullStr	Research progress in dynamic kinetic resolution of azlactone
title_full_unstemmed	Research progress in dynamic kinetic resolution of azlactone
title_sort	research progress in dynamic kinetic resolution of azlactone
publisher	Academic Journals Center of Shanghai Normal University
publishDate	2021
url	https://doaj.org/article/c5e4941fc94c41838cdecfe20540e5c6
work_keys_str_mv	AT huangrenfu researchprogressindynamickineticresolutionofazlactone AT liuqingwen researchprogressindynamickineticresolutionofazlactone AT linjingrong researchprogressindynamickineticresolutionofazlactone AT chengtanyu researchprogressindynamickineticresolutionofazlactone
_version_	1718431315342131200

Research progress in dynamic kinetic resolution of azlactone

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