Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease

Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease

This study describes a class of small molecule compounds that promote ABCA1-dependent cholesterol efflux via a non-transcriptional mechanism, the identification of the molecular target by a chemical biology approach, and the potential of these agents for the treatment of chronic kidney diseases and...

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Autores principales: Matthew B. Wright, Javier Varona Santos, Christian Kemmer, Cyrille Maugeais, Jean-Philippe Carralot, Stephan Roever, Judith Molina, G. Michelle Ducasa, Alla Mitrofanova, Alexis Sloan, Anis Ahmad, Christopher Pedigo, Mengyuan Ge, Jeffrey Pressly, Laura Barisoni, Armando Mendez, Jacopo Sgrignani, Andrea Cavalli, Sandra Merscher, Marco Prunotto, Alessia Fornoni
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/c5e4a9ac05ca4c609714e39b90c7084e
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spelling oai:doaj.org-article:c5e4a9ac05ca4c609714e39b90c7084e2021-12-02T14:53:36ZCompounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease10.1038/s41467-021-24890-32041-1723https://doaj.org/article/c5e4a9ac05ca4c609714e39b90c7084e2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24890-3https://doaj.org/toc/2041-1723This study describes a class of small molecule compounds that promote ABCA1-dependent cholesterol efflux via a non-transcriptional mechanism, the identification of the molecular target by a chemical biology approach, and the potential of these agents for the treatment of chronic kidney diseases and potentially other diseases where lipid accumulation drives disease progression.Matthew B. WrightJavier Varona SantosChristian KemmerCyrille MaugeaisJean-Philippe CarralotStephan RoeverJudith MolinaG. Michelle DucasaAlla MitrofanovaAlexis SloanAnis AhmadChristopher PedigoMengyuan GeJeffrey PresslyLaura BarisoniArmando MendezJacopo SgrignaniAndrea CavalliSandra MerscherMarco PrunottoAlessia FornoniNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Matthew B. Wright
Javier Varona Santos
Christian Kemmer
Cyrille Maugeais
Jean-Philippe Carralot
Stephan Roever
Judith Molina
G. Michelle Ducasa
Alla Mitrofanova
Alexis Sloan
Anis Ahmad
Christopher Pedigo
Mengyuan Ge
Jeffrey Pressly
Laura Barisoni
Armando Mendez
Jacopo Sgrignani
Andrea Cavalli
Sandra Merscher
Marco Prunotto
Alessia Fornoni
Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease
description This study describes a class of small molecule compounds that promote ABCA1-dependent cholesterol efflux via a non-transcriptional mechanism, the identification of the molecular target by a chemical biology approach, and the potential of these agents for the treatment of chronic kidney diseases and potentially other diseases where lipid accumulation drives disease progression.
format article
author Matthew B. Wright
Javier Varona Santos
Christian Kemmer
Cyrille Maugeais
Jean-Philippe Carralot
Stephan Roever
Judith Molina
G. Michelle Ducasa
Alla Mitrofanova
Alexis Sloan
Anis Ahmad
Christopher Pedigo
Mengyuan Ge
Jeffrey Pressly
Laura Barisoni
Armando Mendez
Jacopo Sgrignani
Andrea Cavalli
Sandra Merscher
Marco Prunotto
Alessia Fornoni
author_facet Matthew B. Wright
Javier Varona Santos
Christian Kemmer
Cyrille Maugeais
Jean-Philippe Carralot
Stephan Roever
Judith Molina
G. Michelle Ducasa
Alla Mitrofanova
Alexis Sloan
Anis Ahmad
Christopher Pedigo
Mengyuan Ge
Jeffrey Pressly
Laura Barisoni
Armando Mendez
Jacopo Sgrignani
Andrea Cavalli
Sandra Merscher
Marco Prunotto
Alessia Fornoni
author_sort Matthew B. Wright
title Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease
title_short Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease
title_full Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease
title_fullStr Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease
title_full_unstemmed Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease
title_sort compounds targeting osbpl7 increase abca1-dependent cholesterol efflux preserving kidney function in two models of kidney disease
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/c5e4a9ac05ca4c609714e39b90c7084e
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