Serum Level of Vitamin D Is Associated with Severity of Coronary Atherosclerosis in Postmenopausal Women

<b>Background:</b> Postmenopausal women experience rapid progression of coronary artery disease. Vitamin D deficiency appears to be a modifiable risk factor for cardiovascular diseases. This study aimed to analyze the impact of 25-hydroxyvitamin D3 (25(OH)D) level on the severity of coro...

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Autores principales:	Ewelina Anna Dziedzic, Wiktor Smyk, Izabela Sowińska, Marek Dąbrowski, Piotr Jankowski
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	25(OH)D atherosclerosis coronary artery disease Coronary Artery Surgery Study estrogen deficiency myocardial infarction Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c5e697b72b1349ffaea99c0422fa10cd
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spelling	oai:doaj.org-article:c5e697b72b1349ffaea99c0422fa10cd2021-11-25T16:47:23ZSerum Level of Vitamin D Is Associated with Severity of Coronary Atherosclerosis in Postmenopausal Women10.3390/biology101111392079-7737https://doaj.org/article/c5e697b72b1349ffaea99c0422fa10cd2021-11-01T00:00:00Zhttps://www.mdpi.com/2079-7737/10/11/1139https://doaj.org/toc/2079-7737<b>Background:</b> Postmenopausal women experience rapid progression of coronary artery disease. Vitamin D deficiency appears to be a modifiable risk factor for cardiovascular diseases. This study aimed to analyze the impact of 25-hydroxyvitamin D3 (25(OH)D) level on the severity of coronary atherosclerosis and its potential cardioprotective effect in postmenopausal women. <b>Material and Methods:</b> The study prospectively recruited 351 women in postmenopausal age undergoing coronary angiography. The severity of coronary atherosclerosis was assessed using the Coronary Artery Surgery Study Score (CASSS). A level of 25(OH)D was measured with electrochemiluminescence. <b>Results:</b> Women with more severe coronary atherosclerosis have significantly lower 25(OH)D serum level (<i>p</i> = 0.0001). Vitamin D (β = −0.02; <i>p</i> = 0.016), hypertension (β = 0.44; <i>p</i> = 0.025), age (β = 0.02; <i>p</i> = 0.003), and history of MI (β = 0.63; <i>p</i> < 0.0001), were shown as CASSS determinants. Age, hyperlipidemia, and history of MI were found to determine the level of vitamin D (all <i>p</i> < 0.05). Women with a three-vessel disease hospitalized due to ACS, with a history of MI, hyperlipidemia and hypertension presented the lowest vitamin D level. <b>Conclusions:</b> Our study showed that lower serum 25(OH)D in postmenopausal women is associated with more significant stenosis in the coronary arteries. Therefore, we suggest considering low vitamin D level as a potential risk factor for coronary artery disease.Ewelina Anna DziedzicWiktor SmykIzabela SowińskaMarek DąbrowskiPiotr JankowskiMDPI AGarticle25(OH)Datherosclerosiscoronary artery diseaseCoronary Artery Surgery Studyestrogen deficiencymyocardial infarctionBiology (General)QH301-705.5ENBiology, Vol 10, Iss 1139, p 1139 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	25(OH)D atherosclerosis coronary artery disease Coronary Artery Surgery Study estrogen deficiency myocardial infarction Biology (General) QH301-705.5
spellingShingle	25(OH)D atherosclerosis coronary artery disease Coronary Artery Surgery Study estrogen deficiency myocardial infarction Biology (General) QH301-705.5 Ewelina Anna Dziedzic Wiktor Smyk Izabela Sowińska Marek Dąbrowski Piotr Jankowski Serum Level of Vitamin D Is Associated with Severity of Coronary Atherosclerosis in Postmenopausal Women
description	<b>Background:</b> Postmenopausal women experience rapid progression of coronary artery disease. Vitamin D deficiency appears to be a modifiable risk factor for cardiovascular diseases. This study aimed to analyze the impact of 25-hydroxyvitamin D3 (25(OH)D) level on the severity of coronary atherosclerosis and its potential cardioprotective effect in postmenopausal women. <b>Material and Methods:</b> The study prospectively recruited 351 women in postmenopausal age undergoing coronary angiography. The severity of coronary atherosclerosis was assessed using the Coronary Artery Surgery Study Score (CASSS). A level of 25(OH)D was measured with electrochemiluminescence. <b>Results:</b> Women with more severe coronary atherosclerosis have significantly lower 25(OH)D serum level (<i>p</i> = 0.0001). Vitamin D (β = −0.02; <i>p</i> = 0.016), hypertension (β = 0.44; <i>p</i> = 0.025), age (β = 0.02; <i>p</i> = 0.003), and history of MI (β = 0.63; <i>p</i> < 0.0001), were shown as CASSS determinants. Age, hyperlipidemia, and history of MI were found to determine the level of vitamin D (all <i>p</i> < 0.05). Women with a three-vessel disease hospitalized due to ACS, with a history of MI, hyperlipidemia and hypertension presented the lowest vitamin D level. <b>Conclusions:</b> Our study showed that lower serum 25(OH)D in postmenopausal women is associated with more significant stenosis in the coronary arteries. Therefore, we suggest considering low vitamin D level as a potential risk factor for coronary artery disease.
format	article
author	Ewelina Anna Dziedzic Wiktor Smyk Izabela Sowińska Marek Dąbrowski Piotr Jankowski
author_facet	Ewelina Anna Dziedzic Wiktor Smyk Izabela Sowińska Marek Dąbrowski Piotr Jankowski
author_sort	Ewelina Anna Dziedzic
title	Serum Level of Vitamin D Is Associated with Severity of Coronary Atherosclerosis in Postmenopausal Women
title_short	Serum Level of Vitamin D Is Associated with Severity of Coronary Atherosclerosis in Postmenopausal Women
title_full	Serum Level of Vitamin D Is Associated with Severity of Coronary Atherosclerosis in Postmenopausal Women
title_fullStr	Serum Level of Vitamin D Is Associated with Severity of Coronary Atherosclerosis in Postmenopausal Women
title_full_unstemmed	Serum Level of Vitamin D Is Associated with Severity of Coronary Atherosclerosis in Postmenopausal Women
title_sort	serum level of vitamin d is associated with severity of coronary atherosclerosis in postmenopausal women
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c5e697b72b1349ffaea99c0422fa10cd
work_keys_str_mv	AT ewelinaannadziedzic serumlevelofvitamindisassociatedwithseverityofcoronaryatherosclerosisinpostmenopausalwomen AT wiktorsmyk serumlevelofvitamindisassociatedwithseverityofcoronaryatherosclerosisinpostmenopausalwomen AT izabelasowinska serumlevelofvitamindisassociatedwithseverityofcoronaryatherosclerosisinpostmenopausalwomen AT marekdabrowski serumlevelofvitamindisassociatedwithseverityofcoronaryatherosclerosisinpostmenopausalwomen AT piotrjankowski serumlevelofvitamindisassociatedwithseverityofcoronaryatherosclerosisinpostmenopausalwomen
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Serum Level of Vitamin D Is Associated with Severity of Coronary Atherosclerosis in Postmenopausal Women

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