Bacterial AB5 toxins inhibit the growth of gut bacteria by targeting ganglioside-like glycoconjugates

Bacterial AB5 toxins, such as cholera toxin, bind to oligosaccharides on the host cell surface and play key roles in the pathogenesis of diarrheal disease. Here, Patry et al. show that these toxins bind also to bacterial oligosaccharides and inhibit the growth of Campylobacter jejuni and gut commens...

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Autores principales:	Robert T. Patry, Martin Stahl, Maria Elisa Perez-Munoz, Harald Nothaft, Cory Q. Wenzel, Jessica C. Sacher, Colin Coros, Jens Walter, Bruce A. Vallance, Christine M. Szymanski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c5e73df516cb42219cd70dc2bfef3ef5
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spelling	oai:doaj.org-article:c5e73df516cb42219cd70dc2bfef3ef52021-12-02T14:35:56ZBacterial AB5 toxins inhibit the growth of gut bacteria by targeting ganglioside-like glycoconjugates10.1038/s41467-019-09362-z2041-1723https://doaj.org/article/c5e73df516cb42219cd70dc2bfef3ef52019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09362-zhttps://doaj.org/toc/2041-1723Bacterial AB5 toxins, such as cholera toxin, bind to oligosaccharides on the host cell surface and play key roles in the pathogenesis of diarrheal disease. Here, Patry et al. show that these toxins bind also to bacterial oligosaccharides and inhibit the growth of Campylobacter jejuni and gut commensal bacteria.Robert T. PatryMartin StahlMaria Elisa Perez-MunozHarald NothaftCory Q. WenzelJessica C. SacherColin CorosJens WalterBruce A. VallanceChristine M. SzymanskiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Robert T. Patry Martin Stahl Maria Elisa Perez-Munoz Harald Nothaft Cory Q. Wenzel Jessica C. Sacher Colin Coros Jens Walter Bruce A. Vallance Christine M. Szymanski Bacterial AB5 toxins inhibit the growth of gut bacteria by targeting ganglioside-like glycoconjugates
description	Bacterial AB5 toxins, such as cholera toxin, bind to oligosaccharides on the host cell surface and play key roles in the pathogenesis of diarrheal disease. Here, Patry et al. show that these toxins bind also to bacterial oligosaccharides and inhibit the growth of Campylobacter jejuni and gut commensal bacteria.
format	article
author	Robert T. Patry Martin Stahl Maria Elisa Perez-Munoz Harald Nothaft Cory Q. Wenzel Jessica C. Sacher Colin Coros Jens Walter Bruce A. Vallance Christine M. Szymanski
author_facet	Robert T. Patry Martin Stahl Maria Elisa Perez-Munoz Harald Nothaft Cory Q. Wenzel Jessica C. Sacher Colin Coros Jens Walter Bruce A. Vallance Christine M. Szymanski
author_sort	Robert T. Patry
title	Bacterial AB5 toxins inhibit the growth of gut bacteria by targeting ganglioside-like glycoconjugates
title_short	Bacterial AB5 toxins inhibit the growth of gut bacteria by targeting ganglioside-like glycoconjugates
title_full	Bacterial AB5 toxins inhibit the growth of gut bacteria by targeting ganglioside-like glycoconjugates
title_fullStr	Bacterial AB5 toxins inhibit the growth of gut bacteria by targeting ganglioside-like glycoconjugates
title_full_unstemmed	Bacterial AB5 toxins inhibit the growth of gut bacteria by targeting ganglioside-like glycoconjugates
title_sort	bacterial ab5 toxins inhibit the growth of gut bacteria by targeting ganglioside-like glycoconjugates
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c5e73df516cb42219cd70dc2bfef3ef5
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Bacterial AB5 toxins inhibit the growth of gut bacteria by targeting ganglioside-like glycoconjugates

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