Enhanced bioavailability and efficiency of curcumin for the treatment of asthma by its formulation in solid lipid nanoparticles

Wenrui Wang,1,* Rongrong Zhu,1,* Qian Xie,1 Ang Li,1 Yu Xiao,1 Kun Li,1 Hui Liu,2 Daxiang Cui,3 Yihan Chen,1 Shilong Wang11East Hospital, School of Life Science and Technology, Tongji University, Shanghai, People&rsquo;s Republic of China; 2Eastern Hepatobiliary Surgery Hospital, Second Mili...

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Autores principales:	Wang W, Zhu R, Xie Q, Li A, Xiao Y, Liu H, Cui D, Chen Y, Wang S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c5e8662934ed4ca89f8f8c2ae57f9fb5
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spelling	oai:doaj.org-article:c5e8662934ed4ca89f8f8c2ae57f9fb52021-12-02T02:17:53ZEnhanced bioavailability and efficiency of curcumin for the treatment of asthma by its formulation in solid lipid nanoparticles1176-91141178-2013https://doaj.org/article/c5e8662934ed4ca89f8f8c2ae57f9fb52012-07-01T00:00:00Zhttp://www.dovepress.com/enhanced-bioavailability-and-efficiency-of-curcumin-for-the-treatment--a10419https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Wenrui Wang,1,* Rongrong Zhu,1,* Qian Xie,1 Ang Li,1 Yu Xiao,1 Kun Li,1 Hui Liu,2 Daxiang Cui,3 Yihan Chen,1 Shilong Wang11East Hospital, School of Life Science and Technology, Tongji University, Shanghai, People&rsquo;s Republic of China; 2Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, People&rsquo;s Republic of China; 3National Key Laboratory of Nano/Micro Fabrication Technology, Shanghai Jiao Tong University, Shanghai, People&rsquo;s Republic of China*These authors contributed equally to this studyAbstract: Curcumin has shown considerable pharmacological activity, including anti-inflammatory, but its poor bioavailability and rapid metabolization have limited its application. The purpose of the present study was to formulate curcumin-solid lipid nanoparticles (curcumin-SLNs) to improve its therapeutic efficacy in an ovalbumin (OVA)-induced allergic rat model of asthma. A solvent injection method was used to prepare the curcumin-SLNs. Physiochemical properties of curcumin-SLNs were characterized, and release experiments were performed in vitro. The pharmacokinetics in tissue distribution was studied in mice, and the therapeutic effect of the formulation was evaluated in the model. The prepared formulation showed an average size of 190 nm with a zeta potential value of -20.7 mV and 75% drug entrapment efficiency. X-ray diffraction analysis revealed the amorphous nature of the encapsulated curcumin. The release profile of curcumin-SLNs was an initial burst followed by sustained release. The curcumin concentrations in plasma suspension were significantly higher than those obtained with curcumin alone. Following administration of the curcumin-SLNs, all the tissue concentrations of curcumin increased, especially in lung and liver. In the animal model of asthma, curcumin-SLNs effectively suppressed airway hyperresponsiveness and inflammatory cell infiltration and also significantly inhibited the expression of T-helper-2-type cytokines, such as interleukin-4 and interleukin-13, in bronchoalveolar lavage fluid compared to the asthma group and curcumin-treated group. These observations implied that curcumin-SLNs could be a promising candidate for asthma therapy.Keywords: airway hyperresponsiveness, pharmacokinetics, curcumin, solid lipid nanoparticlesWang WZhu RXie QLi AXiao YLiu HCui DChen YWang SDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 3667-3677 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Wang W Zhu R Xie Q Li A Xiao Y Liu H Cui D Chen Y Wang S Enhanced bioavailability and efficiency of curcumin for the treatment of asthma by its formulation in solid lipid nanoparticles
description	Wenrui Wang,1,* Rongrong Zhu,1,* Qian Xie,1 Ang Li,1 Yu Xiao,1 Kun Li,1 Hui Liu,2 Daxiang Cui,3 Yihan Chen,1 Shilong Wang11East Hospital, School of Life Science and Technology, Tongji University, Shanghai, People&rsquo;s Republic of China; 2Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, People&rsquo;s Republic of China; 3National Key Laboratory of Nano/Micro Fabrication Technology, Shanghai Jiao Tong University, Shanghai, People&rsquo;s Republic of China*These authors contributed equally to this studyAbstract: Curcumin has shown considerable pharmacological activity, including anti-inflammatory, but its poor bioavailability and rapid metabolization have limited its application. The purpose of the present study was to formulate curcumin-solid lipid nanoparticles (curcumin-SLNs) to improve its therapeutic efficacy in an ovalbumin (OVA)-induced allergic rat model of asthma. A solvent injection method was used to prepare the curcumin-SLNs. Physiochemical properties of curcumin-SLNs were characterized, and release experiments were performed in vitro. The pharmacokinetics in tissue distribution was studied in mice, and the therapeutic effect of the formulation was evaluated in the model. The prepared formulation showed an average size of 190 nm with a zeta potential value of -20.7 mV and 75% drug entrapment efficiency. X-ray diffraction analysis revealed the amorphous nature of the encapsulated curcumin. The release profile of curcumin-SLNs was an initial burst followed by sustained release. The curcumin concentrations in plasma suspension were significantly higher than those obtained with curcumin alone. Following administration of the curcumin-SLNs, all the tissue concentrations of curcumin increased, especially in lung and liver. In the animal model of asthma, curcumin-SLNs effectively suppressed airway hyperresponsiveness and inflammatory cell infiltration and also significantly inhibited the expression of T-helper-2-type cytokines, such as interleukin-4 and interleukin-13, in bronchoalveolar lavage fluid compared to the asthma group and curcumin-treated group. These observations implied that curcumin-SLNs could be a promising candidate for asthma therapy.Keywords: airway hyperresponsiveness, pharmacokinetics, curcumin, solid lipid nanoparticles
format	article
author	Wang W Zhu R Xie Q Li A Xiao Y Liu H Cui D Chen Y Wang S
author_facet	Wang W Zhu R Xie Q Li A Xiao Y Liu H Cui D Chen Y Wang S
author_sort	Wang W
title	Enhanced bioavailability and efficiency of curcumin for the treatment of asthma by its formulation in solid lipid nanoparticles
title_short	Enhanced bioavailability and efficiency of curcumin for the treatment of asthma by its formulation in solid lipid nanoparticles
title_full	Enhanced bioavailability and efficiency of curcumin for the treatment of asthma by its formulation in solid lipid nanoparticles
title_fullStr	Enhanced bioavailability and efficiency of curcumin for the treatment of asthma by its formulation in solid lipid nanoparticles
title_full_unstemmed	Enhanced bioavailability and efficiency of curcumin for the treatment of asthma by its formulation in solid lipid nanoparticles
title_sort	enhanced bioavailability and efficiency of curcumin for the treatment of asthma by its formulation in solid lipid nanoparticles
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/c5e8662934ed4ca89f8f8c2ae57f9fb5
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Enhanced bioavailability and efficiency of curcumin for the treatment of asthma by its formulation in solid lipid nanoparticles

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