The role of cardiovascular risk factors in maternal cardiovascular disease according to offspring birth characteristics in the HUNT study

Abstract A history of preterm or small (SGA) or large (LGA) for gestational age offspring is associated with smoking and unfavorable levels of BMI, blood pressure, glucose and lipids. Whether and to what extent the excess cardiovascular risk observed in women with these pregnancy complications is ex...

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Autores principales:	Eirin B. Haug, Amanda R. Markovitz, Abigail Fraser, Håvard Dalen, Pål R. Romundstad, Bjørn O. Åsvold, Janet W. Rich-Edwards, Julie Horn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c5eda03f776b490d906cc68ebcddcf99
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spelling	oai:doaj.org-article:c5eda03f776b490d906cc68ebcddcf992021-11-28T12:20:42ZThe role of cardiovascular risk factors in maternal cardiovascular disease according to offspring birth characteristics in the HUNT study10.1038/s41598-021-99478-42045-2322https://doaj.org/article/c5eda03f776b490d906cc68ebcddcf992021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99478-4https://doaj.org/toc/2045-2322Abstract A history of preterm or small (SGA) or large (LGA) for gestational age offspring is associated with smoking and unfavorable levels of BMI, blood pressure, glucose and lipids. Whether and to what extent the excess cardiovascular risk observed in women with these pregnancy complications is explained by conventional cardiovascular risk factors (CVRFs) is not known. We examined the association between a history of SGA, LGA or preterm birth and cardiovascular disease among 23,284 parous women and quantified the contribution of individual CVRFs to the excess cardiovascular risk using an inverse odds weighting approach. The hazard ratios (HR) between SGA and LGA offspring and CVD were 1.30 (95% confidence interval (CI) 1.15, 1.48) and 0.89 (95% CI 0.76, 1.03), respectively. Smoking explained 49% and blood pressure may have explained ≈12% of the excess cardiovascular risk in women with SGA offspring. Women with preterm birth had a 24% increased risk of CVD (HR 1.24, 95% CI 1.06, 1.45), but we found no evidence for CVRFs explaining any of this excess cardiovascular risk. While smoking explains a substantial proportion of excess cardiovascular risk in women with SGA offspring and blood pressure may explain a small proportion in these women, we found no evidence that conventional CVRFs explain any of the excess cardiovascular risk in women with preterm birth.Eirin B. HaugAmanda R. MarkovitzAbigail FraserHåvard DalenPål R. RomundstadBjørn O. ÅsvoldJanet W. Rich-EdwardsJulie HornNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eirin B. Haug Amanda R. Markovitz Abigail Fraser Håvard Dalen Pål R. Romundstad Bjørn O. Åsvold Janet W. Rich-Edwards Julie Horn The role of cardiovascular risk factors in maternal cardiovascular disease according to offspring birth characteristics in the HUNT study
description	Abstract A history of preterm or small (SGA) or large (LGA) for gestational age offspring is associated with smoking and unfavorable levels of BMI, blood pressure, glucose and lipids. Whether and to what extent the excess cardiovascular risk observed in women with these pregnancy complications is explained by conventional cardiovascular risk factors (CVRFs) is not known. We examined the association between a history of SGA, LGA or preterm birth and cardiovascular disease among 23,284 parous women and quantified the contribution of individual CVRFs to the excess cardiovascular risk using an inverse odds weighting approach. The hazard ratios (HR) between SGA and LGA offspring and CVD were 1.30 (95% confidence interval (CI) 1.15, 1.48) and 0.89 (95% CI 0.76, 1.03), respectively. Smoking explained 49% and blood pressure may have explained ≈12% of the excess cardiovascular risk in women with SGA offspring. Women with preterm birth had a 24% increased risk of CVD (HR 1.24, 95% CI 1.06, 1.45), but we found no evidence for CVRFs explaining any of this excess cardiovascular risk. While smoking explains a substantial proportion of excess cardiovascular risk in women with SGA offspring and blood pressure may explain a small proportion in these women, we found no evidence that conventional CVRFs explain any of the excess cardiovascular risk in women with preterm birth.
format	article
author	Eirin B. Haug Amanda R. Markovitz Abigail Fraser Håvard Dalen Pål R. Romundstad Bjørn O. Åsvold Janet W. Rich-Edwards Julie Horn
author_facet	Eirin B. Haug Amanda R. Markovitz Abigail Fraser Håvard Dalen Pål R. Romundstad Bjørn O. Åsvold Janet W. Rich-Edwards Julie Horn
author_sort	Eirin B. Haug
title	The role of cardiovascular risk factors in maternal cardiovascular disease according to offspring birth characteristics in the HUNT study
title_short	The role of cardiovascular risk factors in maternal cardiovascular disease according to offspring birth characteristics in the HUNT study
title_full	The role of cardiovascular risk factors in maternal cardiovascular disease according to offspring birth characteristics in the HUNT study
title_fullStr	The role of cardiovascular risk factors in maternal cardiovascular disease according to offspring birth characteristics in the HUNT study
title_full_unstemmed	The role of cardiovascular risk factors in maternal cardiovascular disease according to offspring birth characteristics in the HUNT study
title_sort	role of cardiovascular risk factors in maternal cardiovascular disease according to offspring birth characteristics in the hunt study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c5eda03f776b490d906cc68ebcddcf99
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The role of cardiovascular risk factors in maternal cardiovascular disease according to offspring birth characteristics in the HUNT study

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