Anterior/posterior competitive deactivation/activation dichotomy in the human hippocampus as revealed by a 3D navigation task.

Anterior/posterior long axis specialization is thought to underlie the organization of the hippocampus. However it remains unclear whether antagonistic mechanisms differentially modulate processing of spatial information within the hippocampus. We used fMRI and a virtual reality 3D paradigm to study...

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Autores principales:	Isabel Catarina Duarte, Carlos Ferreira, João Marques, Miguel Castelo-Branco
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c5f07e233ca942da83d5c77bcc836a4a
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spelling	oai:doaj.org-article:c5f07e233ca942da83d5c77bcc836a4a2021-11-18T08:35:44ZAnterior/posterior competitive deactivation/activation dichotomy in the human hippocampus as revealed by a 3D navigation task.1932-620310.1371/journal.pone.0086213https://doaj.org/article/c5f07e233ca942da83d5c77bcc836a4a2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24475088/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Anterior/posterior long axis specialization is thought to underlie the organization of the hippocampus. However it remains unclear whether antagonistic mechanisms differentially modulate processing of spatial information within the hippocampus. We used fMRI and a virtual reality 3D paradigm to study encoding and retrieval of spatial memory during active visuospatial navigation, requiring positional encoding and retrieval of object landmarks during the path. Both encoding and retrieval elicited BOLD activation of the posterior most portion of hippocampus, while concurrent deactivations (recently shown to reflect decreases in neural responses) were found in the most anterior regions. Encoding elicited stronger activity in the posterior right than the left hippocampus. The former structure also showed significantly stronger activity for allocentric vs. egocentric processing during retrieval. The anterior vs. posterior pattern mimics, from a functional point, although at much distinct temporal scales, the previous anatomical findings in London taxi drivers, whereby posterior enlargement was found at the cost of an anterior decrease, and the mirror symmetric findings observed in blind people, in whom the right anterior hippocampus was found to be larger, at the cost of a smaller posterior hippocampus, as compared with sighted people. In sum, we found a functional dichotomy whereby the anterior/posterior hippocampus shows antagonistic processing patterns for spatial encoding and retrieval of 3D spatial information. To our knowledge, this is the first study reporting such a dynamical pattern in a functional study, which suggests that differential modulation of neural responses within the human hippocampus reflects distinct roles in spatial memory processing.Isabel Catarina DuarteCarlos FerreiraJoão MarquesMiguel Castelo-BrancoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e86213 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Isabel Catarina Duarte Carlos Ferreira João Marques Miguel Castelo-Branco Anterior/posterior competitive deactivation/activation dichotomy in the human hippocampus as revealed by a 3D navigation task.
description	Anterior/posterior long axis specialization is thought to underlie the organization of the hippocampus. However it remains unclear whether antagonistic mechanisms differentially modulate processing of spatial information within the hippocampus. We used fMRI and a virtual reality 3D paradigm to study encoding and retrieval of spatial memory during active visuospatial navigation, requiring positional encoding and retrieval of object landmarks during the path. Both encoding and retrieval elicited BOLD activation of the posterior most portion of hippocampus, while concurrent deactivations (recently shown to reflect decreases in neural responses) were found in the most anterior regions. Encoding elicited stronger activity in the posterior right than the left hippocampus. The former structure also showed significantly stronger activity for allocentric vs. egocentric processing during retrieval. The anterior vs. posterior pattern mimics, from a functional point, although at much distinct temporal scales, the previous anatomical findings in London taxi drivers, whereby posterior enlargement was found at the cost of an anterior decrease, and the mirror symmetric findings observed in blind people, in whom the right anterior hippocampus was found to be larger, at the cost of a smaller posterior hippocampus, as compared with sighted people. In sum, we found a functional dichotomy whereby the anterior/posterior hippocampus shows antagonistic processing patterns for spatial encoding and retrieval of 3D spatial information. To our knowledge, this is the first study reporting such a dynamical pattern in a functional study, which suggests that differential modulation of neural responses within the human hippocampus reflects distinct roles in spatial memory processing.
format	article
author	Isabel Catarina Duarte Carlos Ferreira João Marques Miguel Castelo-Branco
author_facet	Isabel Catarina Duarte Carlos Ferreira João Marques Miguel Castelo-Branco
author_sort	Isabel Catarina Duarte
title	Anterior/posterior competitive deactivation/activation dichotomy in the human hippocampus as revealed by a 3D navigation task.
title_short	Anterior/posterior competitive deactivation/activation dichotomy in the human hippocampus as revealed by a 3D navigation task.
title_full	Anterior/posterior competitive deactivation/activation dichotomy in the human hippocampus as revealed by a 3D navigation task.
title_fullStr	Anterior/posterior competitive deactivation/activation dichotomy in the human hippocampus as revealed by a 3D navigation task.
title_full_unstemmed	Anterior/posterior competitive deactivation/activation dichotomy in the human hippocampus as revealed by a 3D navigation task.
title_sort	anterior/posterior competitive deactivation/activation dichotomy in the human hippocampus as revealed by a 3d navigation task.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/c5f07e233ca942da83d5c77bcc836a4a
work_keys_str_mv	AT isabelcatarinaduarte anteriorposteriorcompetitivedeactivationactivationdichotomyinthehumanhippocampusasrevealedbya3dnavigationtask AT carlosferreira anteriorposteriorcompetitivedeactivationactivationdichotomyinthehumanhippocampusasrevealedbya3dnavigationtask AT joaomarques anteriorposteriorcompetitivedeactivationactivationdichotomyinthehumanhippocampusasrevealedbya3dnavigationtask AT miguelcastelobranco anteriorposteriorcompetitivedeactivationactivationdichotomyinthehumanhippocampusasrevealedbya3dnavigationtask
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Anterior/posterior competitive deactivation/activation dichotomy in the human hippocampus as revealed by a 3D navigation task.

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