A binding cooperativity switch driven by synergistic structural swelling of an osmo-regulatory protein pair

The bacterial protein Cnu together with the transcription repressor H-NS regulate expression of virulence factors in an osmo-sensitive manner. Here authors show that the structure of Cnu swells with decreasing ionic strength driving the oligomerization of H-NS and regulating osmo-sensory response.

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Auteurs principaux:	Abhishek Narayan, Soundhararajan Gopi, David Fushman, Athi N. Naganathan
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/c5f2bfeffc4b4a10bc4d15207c703514
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spelling	oai:doaj.org-article:c5f2bfeffc4b4a10bc4d15207c7035142021-12-02T16:58:03ZA binding cooperativity switch driven by synergistic structural swelling of an osmo-regulatory protein pair10.1038/s41467-019-10002-92041-1723https://doaj.org/article/c5f2bfeffc4b4a10bc4d15207c7035142019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10002-9https://doaj.org/toc/2041-1723The bacterial protein Cnu together with the transcription repressor H-NS regulate expression of virulence factors in an osmo-sensitive manner. Here authors show that the structure of Cnu swells with decreasing ionic strength driving the oligomerization of H-NS and regulating osmo-sensory response.Abhishek NarayanSoundhararajan GopiDavid FushmanAthi N. NaganathanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Abhishek Narayan Soundhararajan Gopi David Fushman Athi N. Naganathan A binding cooperativity switch driven by synergistic structural swelling of an osmo-regulatory protein pair
description	The bacterial protein Cnu together with the transcription repressor H-NS regulate expression of virulence factors in an osmo-sensitive manner. Here authors show that the structure of Cnu swells with decreasing ionic strength driving the oligomerization of H-NS and regulating osmo-sensory response.
format	article
author	Abhishek Narayan Soundhararajan Gopi David Fushman Athi N. Naganathan
author_facet	Abhishek Narayan Soundhararajan Gopi David Fushman Athi N. Naganathan
author_sort	Abhishek Narayan
title	A binding cooperativity switch driven by synergistic structural swelling of an osmo-regulatory protein pair
title_short	A binding cooperativity switch driven by synergistic structural swelling of an osmo-regulatory protein pair
title_full	A binding cooperativity switch driven by synergistic structural swelling of an osmo-regulatory protein pair
title_fullStr	A binding cooperativity switch driven by synergistic structural swelling of an osmo-regulatory protein pair
title_full_unstemmed	A binding cooperativity switch driven by synergistic structural swelling of an osmo-regulatory protein pair
title_sort	binding cooperativity switch driven by synergistic structural swelling of an osmo-regulatory protein pair
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c5f2bfeffc4b4a10bc4d15207c703514
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A binding cooperativity switch driven by synergistic structural swelling of an osmo-regulatory protein pair

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