LncRNA CASC11 is upregulated in postmenopausal osteoporosis and is correlated with TNF-α

Haotao Yu, Wei Zhou, Weiming Yan, Zhongqi Xu, Yinhao Xie, Ping Zhang Department of Orthopedics, Division 1, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou City, Guangdong Province 510000, People’s Republic of ChinaCorrespondence: Ping ZhangDepartment of Orthopedic...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yu H, Zhou W, Yan W, Xu Z, Xie Y, Zhang P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	postmenopausal osteoporosis CASC11 TNF-α osteoclasts Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/c5f4d9b029e54f229f3bb1f693c4bf75
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c5f4d9b029e54f229f3bb1f693c4bf75
record_format	dspace
spelling	oai:doaj.org-article:c5f4d9b029e54f229f3bb1f693c4bf752021-12-02T05:18:12ZLncRNA CASC11 is upregulated in postmenopausal osteoporosis and is correlated with TNF-α1178-1998https://doaj.org/article/c5f4d9b029e54f229f3bb1f693c4bf752019-09-01T00:00:00Zhttps://www.dovepress.com/lncrna-casc11-is-upregulated-in-postmenopausal-osteoporosis-and-is-cor-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Haotao Yu, Wei Zhou, Weiming Yan, Zhongqi Xu, Yinhao Xie, Ping Zhang Department of Orthopedics, Division 1, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou City, Guangdong Province 510000, People’s Republic of ChinaCorrespondence: Ping ZhangDepartment of Orthopedics, Division 1, The Third Affiliated Hospital of Guangzhou Medical University, No. 63 Duobao Street, Liwan District, Guangzhou City, Guangdong Province 510000, People’s Republic of ChinaTel/Fax +86 0 208 134 6935Email vt94225@163.comPurpose: In this study, we aimed to investigate the role of lncRNA cancer susceptibility 11 (CASC11) and tumor necrosis factor (TNF-α) in postmenopausal osteoporosis (POP).Methods and materials: POP patients and healthy controls were included in this study and levels of CASC11 and TNF-α in plasma of those participants were measured by qPCR and Western blot, respectively. ROC curve was used for diagnostic analysis. Patients were followed up for 2 years and the correlations between the levels of CASC11 and TNF-α and disease conditions were analyzed.Results: We found that CASC11 and TNF-α were both upregulated in plasma of POP patients than in healthy controls. Plasma levels of CASC11 and TNF-α were positively correlated in both POP patients and in healthy controls. Upregulation of CASC11 and TNF-α distinguished POP patients from healthy controls. Treatment and follow-up study showed that high CASC11 levels were significantly correlated with prolonged treatment course and high recurrence rate. Plasma levels of CASC11 and TNF-α decreased after treatment. CASC11 overexpression led to upregulated TNF-α in osteoclasts.Conclusion: CASC11 is upregulated in POP and is correlated with TNF-α.Keywords: postmenopausal osteoporosis, CASC11, TNF-α, osteoclastsYu HZhou WYan WXu ZXie YZhang PDove Medical Pressarticlepostmenopausal osteoporosisCASC11TNF-αosteoclastsGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 14, Pp 1663-1669 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	postmenopausal osteoporosis CASC11 TNF-α osteoclasts Geriatrics RC952-954.6
spellingShingle	postmenopausal osteoporosis CASC11 TNF-α osteoclasts Geriatrics RC952-954.6 Yu H Zhou W Yan W Xu Z Xie Y Zhang P LncRNA CASC11 is upregulated in postmenopausal osteoporosis and is correlated with TNF-α
description	Haotao Yu, Wei Zhou, Weiming Yan, Zhongqi Xu, Yinhao Xie, Ping Zhang Department of Orthopedics, Division 1, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou City, Guangdong Province 510000, People’s Republic of ChinaCorrespondence: Ping ZhangDepartment of Orthopedics, Division 1, The Third Affiliated Hospital of Guangzhou Medical University, No. 63 Duobao Street, Liwan District, Guangzhou City, Guangdong Province 510000, People’s Republic of ChinaTel/Fax +86 0 208 134 6935Email vt94225@163.comPurpose: In this study, we aimed to investigate the role of lncRNA cancer susceptibility 11 (CASC11) and tumor necrosis factor (TNF-α) in postmenopausal osteoporosis (POP).Methods and materials: POP patients and healthy controls were included in this study and levels of CASC11 and TNF-α in plasma of those participants were measured by qPCR and Western blot, respectively. ROC curve was used for diagnostic analysis. Patients were followed up for 2 years and the correlations between the levels of CASC11 and TNF-α and disease conditions were analyzed.Results: We found that CASC11 and TNF-α were both upregulated in plasma of POP patients than in healthy controls. Plasma levels of CASC11 and TNF-α were positively correlated in both POP patients and in healthy controls. Upregulation of CASC11 and TNF-α distinguished POP patients from healthy controls. Treatment and follow-up study showed that high CASC11 levels were significantly correlated with prolonged treatment course and high recurrence rate. Plasma levels of CASC11 and TNF-α decreased after treatment. CASC11 overexpression led to upregulated TNF-α in osteoclasts.Conclusion: CASC11 is upregulated in POP and is correlated with TNF-α.Keywords: postmenopausal osteoporosis, CASC11, TNF-α, osteoclasts
format	article
author	Yu H Zhou W Yan W Xu Z Xie Y Zhang P
author_facet	Yu H Zhou W Yan W Xu Z Xie Y Zhang P
author_sort	Yu H
title	LncRNA CASC11 is upregulated in postmenopausal osteoporosis and is correlated with TNF-α
title_short	LncRNA CASC11 is upregulated in postmenopausal osteoporosis and is correlated with TNF-α
title_full	LncRNA CASC11 is upregulated in postmenopausal osteoporosis and is correlated with TNF-α
title_fullStr	LncRNA CASC11 is upregulated in postmenopausal osteoporosis and is correlated with TNF-α
title_full_unstemmed	LncRNA CASC11 is upregulated in postmenopausal osteoporosis and is correlated with TNF-α
title_sort	lncrna casc11 is upregulated in postmenopausal osteoporosis and is correlated with tnf-α
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/c5f4d9b029e54f229f3bb1f693c4bf75
work_keys_str_mv	AT yuh lncrnacasc11isupregulatedinpostmenopausalosteoporosisandiscorrelatedwithtnfalpha AT zhouw lncrnacasc11isupregulatedinpostmenopausalosteoporosisandiscorrelatedwithtnfalpha AT yanw lncrnacasc11isupregulatedinpostmenopausalosteoporosisandiscorrelatedwithtnfalpha AT xuz lncrnacasc11isupregulatedinpostmenopausalosteoporosisandiscorrelatedwithtnfalpha AT xiey lncrnacasc11isupregulatedinpostmenopausalosteoporosisandiscorrelatedwithtnfalpha AT zhangp lncrnacasc11isupregulatedinpostmenopausalosteoporosisandiscorrelatedwithtnfalpha
_version_	1718400497473290240

LncRNA CASC11 is upregulated in postmenopausal osteoporosis and is correlated with TNF-&alpha;

Ejemplares similares

LncRNA CASC11 is upregulated in postmenopausal osteoporosis and is correlated with TNF-α