Immunohistochemical expression of substance P in breast cancer and its association with prognostic parameters and Ki-67 index.

<h4>Background</h4>The neuropeptide substance P is a potential biomarker and therapeutic target in cancer. The main objectives of this study were to investigate the expression level of substance P in different breast cancer molecular subtypes and identify its association with clinicopath...

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Autores principales:	Maha S Al-Keilani, Rana I Elstaty, Mohammad A Alqudah, Asem M Alkhateeb
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c5f58eec8b854c3aab7edc7e87a4ed04
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spelling	oai:doaj.org-article:c5f58eec8b854c3aab7edc7e87a4ed042021-12-02T20:11:04ZImmunohistochemical expression of substance P in breast cancer and its association with prognostic parameters and Ki-67 index.1932-620310.1371/journal.pone.0252616https://doaj.org/article/c5f58eec8b854c3aab7edc7e87a4ed042021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252616https://doaj.org/toc/1932-6203<h4>Background</h4>The neuropeptide substance P is a potential biomarker and therapeutic target in cancer. The main objectives of this study were to investigate the expression level of substance P in different breast cancer molecular subtypes and identify its association with clinicopathological parameters of patients and with Ki-67 index.<h4>Methods</h4>A retrospective analysis was performed for a total of 164 paraffin-embedded breast cancer tissue samples [42 Her2/neu-enriched, 40 luminal A, 42 luminal B (triple-positive) and 40 triple negative subtypes]. The tissue microarray slides containing specimens were used to determine the expression of substance p and Ki-67 by immunohistochemical staining.<h4>Results</h4>The mean age of the cohort was 51.35 years. Twenty two percent of cases had low substance P expression levels (TS ≤ 5), while 78% had high expression levels (TS > 5). A significant association was found between SP expression level and breast cancer molecular subtype (p = 0.002), TNM stage (p = 0.034), pN stage (p = 0.013), axillary lymph node metastasis (p = 0.004), ER and PR statuses (p<0.001) and history of DCIS (p = 0.009). The average percentage of Ki-67 expression was 27.05%. When analyzed as a continuous variable, significant differences were observed between the mean Ki-67 scores and molecular subtype (p = 0.001), grade (p = 0.003), pN stage (p = 0.007), axillary lymph node metastasis (p = 0.001), and ER and PR statuses (p <0.001).<h4>Conclusion</h4>SP is overexpressed in most of the analyzed tissues and has a negative prognostic value in the breast cancer patients. Besides substance P is a potential therapeutic target in breast cancer.Maha S Al-KeilaniRana I ElstatyMohammad A AlqudahAsem M AlkhateebPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0252616 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maha S Al-Keilani Rana I Elstaty Mohammad A Alqudah Asem M Alkhateeb Immunohistochemical expression of substance P in breast cancer and its association with prognostic parameters and Ki-67 index.
description	<h4>Background</h4>The neuropeptide substance P is a potential biomarker and therapeutic target in cancer. The main objectives of this study were to investigate the expression level of substance P in different breast cancer molecular subtypes and identify its association with clinicopathological parameters of patients and with Ki-67 index.<h4>Methods</h4>A retrospective analysis was performed for a total of 164 paraffin-embedded breast cancer tissue samples [42 Her2/neu-enriched, 40 luminal A, 42 luminal B (triple-positive) and 40 triple negative subtypes]. The tissue microarray slides containing specimens were used to determine the expression of substance p and Ki-67 by immunohistochemical staining.<h4>Results</h4>The mean age of the cohort was 51.35 years. Twenty two percent of cases had low substance P expression levels (TS ≤ 5), while 78% had high expression levels (TS > 5). A significant association was found between SP expression level and breast cancer molecular subtype (p = 0.002), TNM stage (p = 0.034), pN stage (p = 0.013), axillary lymph node metastasis (p = 0.004), ER and PR statuses (p<0.001) and history of DCIS (p = 0.009). The average percentage of Ki-67 expression was 27.05%. When analyzed as a continuous variable, significant differences were observed between the mean Ki-67 scores and molecular subtype (p = 0.001), grade (p = 0.003), pN stage (p = 0.007), axillary lymph node metastasis (p = 0.001), and ER and PR statuses (p <0.001).<h4>Conclusion</h4>SP is overexpressed in most of the analyzed tissues and has a negative prognostic value in the breast cancer patients. Besides substance P is a potential therapeutic target in breast cancer.
format	article
author	Maha S Al-Keilani Rana I Elstaty Mohammad A Alqudah Asem M Alkhateeb
author_facet	Maha S Al-Keilani Rana I Elstaty Mohammad A Alqudah Asem M Alkhateeb
author_sort	Maha S Al-Keilani
title	Immunohistochemical expression of substance P in breast cancer and its association with prognostic parameters and Ki-67 index.
title_short	Immunohistochemical expression of substance P in breast cancer and its association with prognostic parameters and Ki-67 index.
title_full	Immunohistochemical expression of substance P in breast cancer and its association with prognostic parameters and Ki-67 index.
title_fullStr	Immunohistochemical expression of substance P in breast cancer and its association with prognostic parameters and Ki-67 index.
title_full_unstemmed	Immunohistochemical expression of substance P in breast cancer and its association with prognostic parameters and Ki-67 index.
title_sort	immunohistochemical expression of substance p in breast cancer and its association with prognostic parameters and ki-67 index.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/c5f58eec8b854c3aab7edc7e87a4ed04
work_keys_str_mv	AT mahasalkeilani immunohistochemicalexpressionofsubstancepinbreastcanceranditsassociationwithprognosticparametersandki67index AT ranaielstaty immunohistochemicalexpressionofsubstancepinbreastcanceranditsassociationwithprognosticparametersandki67index AT mohammadaalqudah immunohistochemicalexpressionofsubstancepinbreastcanceranditsassociationwithprognosticparametersandki67index AT asemmalkhateeb immunohistochemicalexpressionofsubstancepinbreastcanceranditsassociationwithprognosticparametersandki67index
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Immunohistochemical expression of substance P in breast cancer and its association with prognostic parameters and Ki-67 index.

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